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Gene Review

TPM1  -  tropomyosin 1 (alpha)

Gallus gallus

 
 
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Disease relevance of TPM1

 

High impact information on TPM1

 

Chemical compound and disease context of TPM1

 

Biological context of TPM1

 

Anatomical context of TPM1

  • Isolation and sequence of a cDNA clone that contains the entire coding region for chicken smooth-muscle alpha-tropomyosin [11].
  • The striated alpha-tropomyosin incorporated into stress fibers, even though this isoform is not found in nonmuscle cells [13].
  • In order to test the effect of all-trans RA and 13-cis RA on cardiomyocyte differentiation, we studied the level and the subcellular compartmentalization of alpha-tropomyosin and troponin-T proteins in cultures of chick embryo cardiomyocytes obtained from Hamburger and Hamilton's (HH) stage 22, 32 and 40 embryos [14].
  • The greatest increases in alpha-tropomyosin occurred in the cytoplasmic fraction in HH22 cells cultured for 24 h with all-trans RA or 13-cis RA, whereas the greatest increases in troponin-T were found in the cytoplasmic fraction of HH32 cells exposed to retinoids for 24 h [14].
  • Both phospholamban and skeletal alpha-tropomyosin messages in the myocardium of the AV canal region showed significant decrease during this period of the development [15].
 

Enzymatic interactions of TPM1

 

Other interactions of TPM1

 

Analytical, diagnostic and therapeutic context of TPM1

References

  1. Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group. Monteiro, P.B., Lataro, R.C., Ferro, J.A., Reinach, F.d.e. .C. J. Biol. Chem. (1994) [Pubmed]
  2. Requirement of amino-terminal modification for striated muscle alpha-tropomyosin function. Urbancikova, M., Hitchcock-DeGregori, S.E. J. Biol. Chem. (1994) [Pubmed]
  3. Isolation and characterization of related cDNA clones encoding skeletal muscle beta-tropomyosin and a low-molecular-weight nonmuscle tropomyosin isoform. Bradac, J.A., Gruber, C.E., Forry-Schaudies, S., Hughes, S.H. Mol. Cell. Biol. (1989) [Pubmed]
  4. Effect of the structure of the N terminus of tropomyosin on tropomodulin function. Kostyukova, A.S., Hitchcock-DeGregori, S.E. J. Biol. Chem. (2004) [Pubmed]
  5. Quantitative analysis of tropomyosin linear polymerization equilibrium as a function of ionic strength. Sousa, A.D., Farah, C.S. J. Biol. Chem. (2002) [Pubmed]
  6. The chicken tropomyosin 1 gene generates nine mRNAs by alternative splicing. Forry-Schaudies, S., Hughes, S.H. J. Biol. Chem. (1991) [Pubmed]
  7. Altered actin and troponin binding of amino-terminal variants of chicken striated muscle alpha-tropomyosin expressed in Escherichia coli. Hitchcock-DeGregori, S.E., Heald, R.W. J. Biol. Chem. (1987) [Pubmed]
  8. Chick alpha tropomyosin gene contains three sets of mutually exclusive alternatively spliced exons. Lemonnier, M., Libri, D., Fiszman, M.Y. Nucleic Acids Res. (1989) [Pubmed]
  9. Complete nucleotide sequence of the fast-twitch isoform of chicken skeletal muscle alpha-tropomyosin. Gooding, C., Reinach, F.C., Macleod, A.R. Nucleic Acids Res. (1987) [Pubmed]
  10. Distinct alpha-tropomyosin mRNA sequences in chicken skeletal muscle. MacLeod, A.R. Eur. J. Biochem. (1982) [Pubmed]
  11. Isolation and sequence of a cDNA clone that contains the entire coding region for chicken smooth-muscle alpha-tropomyosin. Helfman, D.M., Feramisco, J.R., Ricci, W.M., Hughes, S.H. J. Biol. Chem. (1984) [Pubmed]
  12. In vitro phosphorylation of tropomyosin by a kinase from chicken embryo. Montgomery, K., Mak, A.S. J. Biol. Chem. (1984) [Pubmed]
  13. Incorporation of microinjected mutant and wildtype recombinant tropomyosins into stress fibers in fibroblasts. Ranucci, D., Yamakita, Y., Matsumura, F., Hitchcock-DeGregori, S.E. Cell Motil. Cytoskeleton (1993) [Pubmed]
  14. Contractile regulatory proteins tropomyosin and troponin-T as indicators of the modulatory role of retinoic acid. Vélez, C., Aránega, A.E., Marchal, J.A., Prados, J., Melguizo, C., Carrillo, E., Boulaiz, H., Madeddu, R., Sánchez-Montesinos, I., Aránega, A. Cells Tissues Organs (Print) (2003) [Pubmed]
  15. Differential displaying of mRNAs from the atrioventricular region of developing chicken hearts at stages 15 and 21. Wang, D.Z., Hu, X., Lin, J.L., Kitten, G.T., Solursh, M., Lin, J.J. Front. Biosci. (1996) [Pubmed]
  16. Tropomyosin has discrete actin-binding sites with sevenfold and fourteenfold periodicities. Hitchcock-DeGregori, S.E., Varnell, T.A. J. Mol. Biol. (1990) [Pubmed]
  17. Tropomyosin ends determine the stability and functionality of overlap and troponin T complexes. Palm, T., Greenfield, N.J., Hitchcock-DeGregori, S.E. Biophys. J. (2003) [Pubmed]
  18. A radioimmunoassay method for quantification of alpha-tropomyosin in heart homogenates. Moore, P.B., Lemanski, L.F. J. Muscle Res. Cell. Motil. (1982) [Pubmed]
 
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