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Gene Review

Taf6  -  TBP-associated factor 6

Drosophila melanogaster

Synonyms: CG32211, CG9348, Dmel\CG32211, SR3-4B, TAF, ...
 
 
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High impact information on Taf6

  • Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules [1].
  • Within the basal transcription factor complex TFIID, two specific targets, TAFII110 and TAFII60, served as coactivators to mediate transcriptional activation by these two enhancer binding proteins [2].
  • In the presence of TAFII60/70, TBP and TAFII250, a stable ternary complex is formed [3].
  • These results indicate that activation domains and the autoinhibitory domain of TFIID are interchangeable, supporting a role for transcriptional activators as antirepressors of the autoinhibitory activity of the TATA box binding of TFIID [4].
  • This means that the interactions observed in vitro between Bcd and TAFII60 or TAFII110 aid transcriptional activation but are dispensable for normal development [5].
 

Biological context of Taf6

 

Anatomical context of Taf6

  • The results provide evidence that TAF(II)-subunits within the TFIID complex play an important role during the molecular events leading to initiation of mesoderm formation in Drosophila [10].
 

Associations of Taf6 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Taf6

References

  1. Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Xie, X., Kokubo, T., Cohen, S.L., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K. Nature (1996) [Pubmed]
  2. Multiple TAFIIs directing synergistic activation of transcription. Sauer, F., Hansen, S.K., Tjian, R. Science (1995) [Pubmed]
  3. Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. Weinzierl, R.O., Ruppert, S., Dynlacht, B.D., Tanese, N., Tjian, R. EMBO J. (1993) [Pubmed]
  4. A role of transcriptional activators as antirepressors for the autoinhibitory activity of TATA box binding of transcription factor IID. Kotani, T., Banno, K., Ikura, M., Hinnebusch, A.G., Nakatani, Y., Kawaichi, M., Kokubo, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Bicoid functions without its TATA-binding protein-associated factor interaction domains. Schaeffer, V., Janody, F., Loss, C., Desplan, C., Wimmer, E.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Thut, C.J., Chen, J.L., Klemm, R., Tjian, R. Science (1995) [Pubmed]
  7. DNA template and activator-coactivator requirements for transcriptional synergism by Drosophila bicoid. Sauer, F., Hansen, S.K., Tjian, R. Science (1995) [Pubmed]
  8. Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding. Kokubo, T., Yamashita, S., Horikoshi, M., Roeder, R.G., Nakatani, Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Chen, X., Hiller, M., Sancak, Y., Fuller, M.T. Science (2005) [Pubmed]
  10. Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110. Pham, A.D., Müller, S., Sauer, F. Mech. Dev. (1999) [Pubmed]
 
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