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Gene Review

LENEP  -  lens epithelial protein

Homo sapiens

Synonyms: LEP503, Lens epithelial cell protein LEP503
 
 
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Disease relevance of LENEP

 

Psychiatry related information on LENEP

  • CONCLUSION: The individual difference of lens epithelial cell density and proliferation capacity in vivo may be an important underlying cause for senile cataract in the cellular level, especially for nuclear cataract [5].
 

High impact information on LENEP

 

Chemical compound and disease context of LENEP

 

Biological context of LENEP

  • By reporter gene transfection experiments, we found that approximately 2.5-kb of LEP503 5'-flanking sequence directed high level luciferase activity in human lens epithelial cells; further deletion analysis revealed positive regulatory element between bp -401 and +22 [12].
  • The LEP503 gene is mapped to human chromosome 1q22, the same location to which zonular pulverulent cataract was previously mapped [12].
  • In this study, a novel lens epithelium gene product, LEP503, identified from rat by a subtractive cDNA cloning strategy was investigated in the genome organization, mRNA expression and protein localization [13].
  • The genomic sequences for LEP503 isolated from rat, mouse and human span 1754 bp, 1694 bp and 1895 bp regions encompassing the 5'-flanking region, two exons, one intron and 3'-flanking region [13].
  • Both mouse and human LEP503 genes show very high identity (93% for mouse and 79% for human) to rat LEP503 gene in the exon 1 that contains an open reading frame coding for a protein of 61 amino acid residues with a leucine-rich domain [13].
 

Anatomical context of LENEP

 

Associations of LENEP with chemical compounds

 

Regulatory relationships of LENEP

 

Other interactions of LENEP

  • CONCLUSIONS: The above findings suggest that the increased growth potential of human lens epithelial cells by Ad12-SV40 infection maintained certain lens-specific properties and response to PDGF [22].
  • Thioredoxin induced antioxidant gene expressions in human lens epithelial cells [24].
  • Thus, these findings suggest that Abeta aggregates in vivo are possibly involved in the regulatory process by which lens epithelial cells may transdifferentiate into fibroblast-like cells, as well as help understand the mechanisms which lead to certain types of cataractogenesis [25].
  • The work presented therefore demonstrates a platform technology to study TGF-beta2 signalling in human lens epithelial cells and provides evidence to show TGF-beta2 can be a potent factor in the development of posterior capsule opacification following cataract surgery [26].
  • Possible role of amyloid beta-(1-40)-BSA conjugates in transdifferentiation of lens epithelial cells [25].
 

Analytical, diagnostic and therapeutic context of LENEP

References

  1. Propagation and immortalization of human lens epithelial cells in culture. Andley, U.P., Rhim, J.S., Chylack, L.T., Fleming, T.P. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  2. Intercapsular cataract surgery with lens epithelial cell removal. Part IV: Capsular fibrosis induced by poly(methyl methacrylate). Nishi, O., Nishi, K., Sakka, Y., Sakuraba, T., Maeda, S. Journal of cataract and refractive surgery. (1991) [Pubmed]
  3. Cellular reaction on the anterior surface of poly(methyl methacrylate) intraocular lenses. Pande, M.V., Spalton, D.J., Kerr-Muir, M.G., Marshall, J. Journal of cataract and refractive surgery. (1996) [Pubmed]
  4. Intercapsular cataract surgery with lens epithelial cell removal. Part I: Without capsulorhexis. Nishi, O. Journal of cataract and refractive surgery. (1989) [Pubmed]
  5. Lens epithelial cell proliferation and cell density in human age-related cataract. Liu, X., Liu, Y., Zheng, J., Huang, Q., Zheng, H. Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu. (2000) [Pubmed]
  6. Lens epithelial cell elongation in the absence of microtubules: evidence for a new effect of colchicine. Beebe, D.C., Feagans, D.E., Blanchette-Mackie, E.J., Nau, M.E. Science (1979) [Pubmed]
  7. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. Li, W.C., Kuszak, J.R., Dunn, K., Wang, R.R., Ma, W., Wang, G.M., Spector, A., Leib, M., Cotliar, A.M., Weiss, M. J. Cell Biol. (1995) [Pubmed]
  8. The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis. Andley, U.P., Patel, H.C., Xi, J.H. J. Biol. Chem. (2002) [Pubmed]
  9. Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells. Andley, U.P., Song, Z., Wawrousek, E.F., Fleming, T.P., Bassnett, S. J. Biol. Chem. (2000) [Pubmed]
  10. The effects of steroids on the human lens epithelium. Jacob, T.J., Karim, A.K., Thompson, G.M. Eye (London, England) (1987) [Pubmed]
  11. Effects of bicistronic lentiviral vector-mediated herpes simplex virus thymidine kinase/ganciclovir system on human lens epithelial cells. Yang, J., Liu, T.J., Lu, Y. Curr. Eye Res. (2007) [Pubmed]
  12. Functional analysis of the promoter and chromosomal localization for human LEP503, a novel lens epithelium gene. Wen, Y., Ibaraki, N., Reddy, V.N., Sachs, G. Gene (2001) [Pubmed]
  13. A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens. Wen, Y., Sachs, G., Athmann, C. Exp. Eye Res. (2000) [Pubmed]
  14. The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress. Andley, U.P., Song, Z., Wawrousek, E.F., Bassnett, S. J. Biol. Chem. (1998) [Pubmed]
  15. Hepatocyte growth factor/scatter factor in the eye. Grierson, I., Heathcote, L., Hiscott, P., Hogg, P., Briggs, M., Hagan, S. Progress in retinal and eye research. (2000) [Pubmed]
  16. Stimulation of lens cell differentiation by gap junction protein connexin 45.6. Gu, S., Yu, X.S., Yin, X., Jiang, J.X. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  17. Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. Stump, R., Lovicu, F., Ang, S., Pandey, S., McAvoy, J. J. Pathol. (2006) [Pubmed]
  18. The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Dairou, J., Malecaze, F., Dupret, J.M., Rodrigues-Lima, F. Mol. Pharmacol. (2005) [Pubmed]
  19. Thioltranferase mediated ascorbate recycling in human lens epithelial cells. Fernando, M.R., Satake, M., Monnier, V.M., Lou, M.F. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  20. Modulation of lens epithelial cell proliferation by enhanced prostaglandin synthesis after UVB exposure. Andley, U.P., Hebert, J.S., Morrison, A.R., Reddan, J.R., Pentland, A.P. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  21. Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells. Chen, K.C., Zhou, Y., Zhang, W., Lou, M.F. Mol. Vis. (2007) [Pubmed]
  22. Expression of growth control and differentiation genes in human lens epithelial cells with extended life span. Fleming, T.P., Song, Z., Andley, U.P. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  23. An in vitro study of human lens epithelial cell adhesion to intraocular lenses with and without a fibronectin coating. Cooke, C.A., McGimpsey, S., Mahon, G., Best, R.M. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  24. Thioredoxin induced antioxidant gene expressions in human lens epithelial cells. Yegorova, S., Yegorov, O., Lou, M.F. Exp. Eye Res. (2006) [Pubmed]
  25. Possible role of amyloid beta-(1-40)-BSA conjugates in transdifferentiation of lens epithelial cells. Lee, K.W., Seomun, Y., Kim, D.H., Park, S.Y., Joo, C.K. Yonsei Med. J. (2004) [Pubmed]
  26. Characterisation of TGF-beta2 signalling and function in a human lens cell line. Wormstone, I.M., Tamiya, S., Eldred, J.A., Lazaridis, K., Chantry, A., Reddan, J.R., Anderson, I., Duncan, G. Exp. Eye Res. (2004) [Pubmed]
 
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