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Gene Review

Gulo  -  gulonolactone (L-) oxidase

Rattus norvegicus

Synonyms: GLO, L-gulono-gamma-lactone oxidase, L-gulonolactone oxidase, LGO
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Biological context of Gulo


Anatomical context of Gulo


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Analytical, diagnostic and therapeutic context of Gulo


  1. Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species. Nishikimi, M., Kawai, T., Yagi, K. J. Biol. Chem. (1992) [Pubmed]
  2. Production by a baculovirus expression system of the APO-protein of L-gulono-gamma-lactone oxidase, a flavoenzyme possessing a covalently-bound FAD. Nishikimi, M., Kobayashi, J., Yagi, K. Biochem. Mol. Biol. Int. (1994) [Pubmed]
  3. Short-term dermal toxicity and mutagenicity of coal coprocessing products in the rat. Chu, I., Villeneuve, D.C., Secours, V.E., Otson, R., Valli, V.E. Journal of toxicology and environmental health. (1991) [Pubmed]
  4. Effect of malathion, estradiol-17-beta and progesterone on ascorbic acid metabolism in prenatal rats and their pups. Mathews, M.S., Devi, K.S. Veterinary and human toxicology. (1993) [Pubmed]
  5. L-gulonolactone oxidase activity and vitamin C status in riboflavin-deficient rats. Kiuchi, K., Nishikimi, M., Yagi, K. Biochim. Biophys. Acta (1980) [Pubmed]
  6. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. Nishikimi, M., Fukuyama, R., Minoshima, S., Shimizu, N., Yagi, K. J. Biol. Chem. (1994) [Pubmed]
  7. A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. Kawai, T., Nishikimi, M., Ozawa, T., Yagi, K. J. Biol. Chem. (1992) [Pubmed]
  8. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Nishikimi, M., Yagi, K. Am. J. Clin. Nutr. (1991) [Pubmed]
  9. Transgenic expression of L-gulono-gamma-lactone oxidase in medaka (Oryzias latipes), a teleost fish that lacks this enzyme necessary for L-ascorbic acid biosynthesis. Toyohara, H., Nakata, T., Touhata, K., Hashimoto, H., Kinoshita, M., Sakaguchi, M., Nishikimi, M., Yagi, K., Wakamatsu, Y., Ozato, K. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  10. Purification and characterization of L-gulonolactone oxidase from chicken kidney microsomes. Kiuchi, K., Nishikimi, M., Yagi, K. Biochemistry (1982) [Pubmed]
  11. Synthesis of ascorbate and urate in the ovary of water buffalo. Spagnuolo, M.S., Cigliano, L., Balestrieri, M., Porta, A., Abrescia, P. Free Radic. Res. (2001) [Pubmed]
  12. Purification of methylguanidine synthase from the rat kidney. Yokozawa, T., Fujitsuka, N., Oura, H., Akao, T., Kobashi, K., Ienaga, K., Nakamura, K., Hattori, M. Nephron (1993) [Pubmed]
  13. Morphological influence of ascorbic acid deficiency on endochondral ossification in osteogenic disorder Shionogi rat. Sakamoto, Y., Takano, Y. Anat. Rec. (2002) [Pubmed]
  14. L-gulono-gamma-lactone oxidase is not induced in rats by xenobiotics stimulating L-ascorbic acid biosynthesis. Horio, F., Shibata, T., Naito, Y., Nishikimi, M., Yagi, K., Yoshida, A. J. Nutr. Sci. Vitaminol. (1993) [Pubmed]
  15. Isolation and sequence analysis of a complementary DNA encoding rat liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis. Koshizaka, T., Nishikimi, M., Ozawa, T., Yagi, K. J. Biol. Chem. (1988) [Pubmed]
  16. L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver. Fujitsuka, N., Yokozawa, T., Oura, H., Akao, T., Kobashi, K., Ienaga, K., Nakamura, K. Nephron (1993) [Pubmed]
  17. Detection of L-gulono-gamma-lactone oxidase on SDS-polyacrylamide gels by the fluorescence of its covalently bound flavin. Nishikimi, M., Kiuchi, K., Yagi, K. FEBS Lett. (1977) [Pubmed]
  18. Effects of some xenobiotics on ascorbic acid metabolism in rats. Horio, F., Yoshida, A. J. Nutr. (1982) [Pubmed]
  19. Comparison of the anti-scorbutic activity of L-ascorbic acid and Ester C in the non-ascorbate synthesizing Osteogenic Disorder Shionogi (ODS) rat. Verlangieri, A.J., Fay, M.J., Bannon, A.W. Life Sci. (1991) [Pubmed]
  20. Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. Nishikimi, M., Koshizaka, T., Ozawa, T., Yagi, K. Arch. Biochem. Biophys. (1988) [Pubmed]
  21. Effect of castration on the metabolism of L-ascorbic acid in rat prostate. Shah, S., Nath, N. J. Nutr. Sci. Vitaminol. (1985) [Pubmed]
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