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Chemical Compound Review

SureCN418680     (3S,4R,5R)-5-[(1S)-1,2- dihydroxyethyl]-3,4...

Synonyms: CHEBI:17587, HMDB03466, ANW-66746, bmse000235, CTK8C1475, ...
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Disease relevance of L-Gulono-gamma-lactone


High impact information on L-Gulono-gamma-lactone

  • The lactonase reaction with l-gulono-gamma-lactone is the penultimate step in l-ascorbic acid (AA) biosynthesis, and the essential role of SMP30 in this synthetic process was verified here by a nutritional study using SMP30 knockout mice [2].
  • To test the effect of this mutation on the expression of L-gulono-gamma-lactone oxidase, we inserted a region of the cDNAs coding for normal and mutant L-gulono-gamma-lactone oxidases into an expression vector, pSVL, and transfected COS-1 cells with such vectors [3].
  • Sequencing of polymerase chain reaction-amplified cDNAs for mutant and normal rat L-gulono-gamma-lactone oxidases demonstrated that the mutant cDNA has a single base mutation from G to A at nucleotide 182, which mutation alters the 61st amino acid residue from Cys to Tyr [3].
  • Cells infected with Gulo-expressing vectors overexpressed an FAD-containing protein that corresponded in size to that predicted for recombinant GULO protein and expressed a functional enzyme as measured by the conversion of l-gulono-gamma-lactone to ascorbic acid in cell-free extracts [4].
  • This was demonstrated by the absence of L-gulonolactone oxidase activity, the enzyme responsible for the biosynthesis of vitamin C, in liver or kidney of oscars and by a feeding trial in which oscars without vitamin C dietary supplementation developed clinical deficiency signs [5].

Biological context of L-Gulono-gamma-lactone


Anatomical context of L-Gulono-gamma-lactone


Associations of L-Gulono-gamma-lactone with other chemical compounds


Gene context of L-Gulono-gamma-lactone


Analytical, diagnostic and therapeutic context of L-Gulono-gamma-lactone


  1. Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase. Wolucka, B.A., Communi, D. FEBS J. (2006) [Pubmed]
  2. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Kondo, Y., Inai, Y., Sato, Y., Handa, S., Kubo, S., Shimokado, K., Goto, S., Nishikimi, M., Maruyama, N., Ishigami, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. Kawai, T., Nishikimi, M., Ozawa, T., Yagi, K. J. Biol. Chem. (1992) [Pubmed]
  4. Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase. Ha, M.N., Graham, F.L., D'Souza, C.K., Muller, W.J., Igdoura, S.A., Schellhorn, H.E. Genomics (2004) [Pubmed]
  5. Oscars, Astronotus ocellatus, have a dietary requirement for vitamin C. Fracalossi, D.M., Allen, M.E., Nichols, D.K., Oftedal, O.T. J. Nutr. (1998) [Pubmed]
  6. Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells. Kim, H.J., Lee, S.I., Lee, D.H., Smith, D., Jo, H., Schellhorn, H.E., Boo, Y.C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Molecular cloning and expression of a gene encoding a novel sorbitol oxidase from Streptomyces sp. H-7775. Hiraga, K., Eto, T., Yoshioka, I., Oda, K. Biosci. Biotechnol. Biochem. (1998) [Pubmed]
  8. Random nucleotide substitutions in primate nonfunctional gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis. Ohta, Y., Nishikimi, M. Biochim. Biophys. Acta (1999) [Pubmed]
  9. Homo sapiens ascorbicus, a biochemically corrected robust human mutant. Stone, I. Med. Hypotheses (1979) [Pubmed]
  10. Vitamin C. Linster, C.L., Van Schaftingen, E. FEBS J. (2007) [Pubmed]
  11. Glutaraldehyde-reacted immunoprecipitates of L-gulonolactone oxidase are suitable for administration to guinea pigs. Sato, P.H., Walton, D.M. Arch. Biochem. Biophys. (1983) [Pubmed]
  12. L-galactono-gamma-lactone dehydrogenase from sweet potato: purification and cDNA sequence analysis. Imai, T., Karita, S., Shiratori, G., Hattori, M., Nunome, T., Oba, K., Hirai, M. Plant Cell Physiol. (1998) [Pubmed]
  13. Ascorbic acid and L-gulonolactone oxidase in lagomorphs. Jenness, R., Birney, E.C., Ayaz, K.L. Comp. Biochem. Physiol., B (1978) [Pubmed]
  14. Heterologous immunoprecipitates also have potential for therapeutic use. Hadley, K.B., Lindemann, D.A., Sato, P.H. Biotechnol. Appl. Biochem. (1987) [Pubmed]
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