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TAL2  -  T-cell acute lymphocytic leukemia 2

Homo sapiens

 
 
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Disease relevance of TAL2

 

High impact information on TAL2

  • TAL1, TAL2 and LYL1 encode a unique subgroup of basic helix-loop-helix (bHLH) proteins that share exceptional homology in their bHLH sequences [3].
  • TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia [1].
  • The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL [1].
  • We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1 [1].
  • TAL2 potentially encodes a basic helix-loop-helix motif that is highly related to those specified by TAL1 and LYL1, distinct genes that have also been implicated in T-ALL [2].
 

Biological context of TAL2

 

Physical interactions of TAL2

  • TAL2 polypeptides interact in vivo with the E2A gene products (E47 and E12) to form bHLH heterodimers that bind DNA in a sequence-specific manner [2].
 

Other interactions of TAL2

  • Taken together, the properties of TAL2 evaluated here broadly resemble those described previously for TAL1, and therefore support the idea that both proteins promote T-ALL by a common mechanism [2].

References

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Xia, Y., Brown, L., Yang, C.Y., Tsan, J.T., Siciliano, M.J., Espinosa, R., Le Beau, M.M., Baer, R.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. Xia, Y., Hwang, L.Y., Cobb, M.H., Baer, R. Oncogene (1994) [Pubmed]
  3. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. Wadman, I., Li, J., Bash, R.O., Forster, A., Osada, H., Rabbitts, T.H., Baer, R. EMBO J. (1994) [Pubmed]
 
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