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Gene Review

TSPAN8  -  tetraspanin 8

Homo sapiens

Synonyms: CO-029, TM4SF3, Tetraspanin-8, Transmembrane 4 superfamily member 3, Tspan-8, ...
 
 
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Disease relevance of TSPAN8

 

High impact information on TSPAN8

  • The 1.182-kb cDNA codes for a 235-amino acid long molecule with a 74.2% homology in the nucleotide and a 70% homology in the amino acid sequence to CO-029, a human tumor-associated molecule [2].
  • Two other members of this family of proteins, CD63 (ME491) and CO-029, are also highly expressed on tumor cells [4].
  • By using the high-efficiency COS cell expression system, a full-length cDNA clone for CO-029 was isolated [5].
  • CO-029 and ME491 antigen expression and the effect of their corresponding monoclonal antibodies on cell growth were compared in human tumor cell lines of various histologic origins [5].
  • When transiently expressed in COS cells, the cDNA clone directed the synthesis of an antigen reactive to monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays [5].
 

Biological context of TSPAN8

 

Anatomical context of TSPAN8

 

Associations of TSPAN8 with chemical compounds

 

Analytical, diagnostic and therapeutic context of TSPAN8

References

  1. Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. Kanetaka, K., Sakamoto, M., Yamamoto, Y., Yamasaki, S., Lanza, F., Kanematsu, T., Hirohashi, S. J. Hepatol. (2001) [Pubmed]
  2. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. Claas, C., Seiter, S., Claas, A., Savelyeva, L., Schwab, M., Zöller, M. J. Cell Biol. (1998) [Pubmed]
  3. Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility. Gesierich, S., Paret, C., Hildebrand, D., Weitz, J., Zgraggen, K., Schmitz-Winnenthal, F.H., Horejsi, V., Yoshie, O., Herlyn, D., Ashman, L.K., Zöller, M. Clin. Cancer Res. (2005) [Pubmed]
  4. Cloning and expression of the tumor-associated antigen L6. Marken, J.S., Schieven, G.L., Hellström, I., Hellström, K.E., Aruffo, A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Szala, S., Kasai, Y., Steplewski, Z., Rodeck, U., Koprowski, H., Linnenbach, A.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells. Kanetaka, K., Sakamoto, M., Yamamoto, Y., Takamura, M., Kanematsu, T., Hirohashi, S. J. Gastroenterol. Hepatol. (2003) [Pubmed]
  7. Profiling of the tetraspanin web of human colon cancer cells. Le Naour, F., André, M., Greco, C., Billard, M., Sordat, B., Emile, J.F., Lanza, F., Boucheix, C., Rubinstein, E. Mol. Cell Proteomics (2006) [Pubmed]
  8. Colon carcinoma-associated glycoproteins recognized by monoclonal antibodies CO-029 and GA22-2. Sela, B.A., Steplewski, Z., Koprowski, H. Hybridoma (1989) [Pubmed]
 
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