The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC2A10  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: ATS, GLUT-10, GLUT10, Glucose transporter type 10, Solute carrier family 2, facilitated glucose transporter member 10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC2A10

  • The sum of all angiographically detectable lumen stenoses (atherosclerosis score, ATS) was higher in diabetic than in non-diabetic subjects (352 +/- 232 vs 211 +/- 201 units, p < 0.0001) [1].
  • Within the diabetic group, the only variable that was independently (of sex and age) associated with ATS was serum cholesterol, whereas plasma glucose concentration, disease duration and type of treatment were not correlated with the severity of coronary atherosclerosis [1].
  • Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement [2].
  • Chronic bird fancier's lung: histopathological and clinical correlation. An application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias [3].
  • The TE-85 osteosarcoma cell line has several of the in vitro properties of malignant cells, including colony formation in agar, but has low extracellular fibrinolytic activity and no capacity to form tumors in ATS-treated hamsters [4].

Psychiatry related information on SLC2A10

  • Each answered questions detailing ethnic background, medical history, level of physical activity, and length of residence in the United States. Spirometry and single-breath DL(CO) maneuvers were performed in accordance with ATS standards [5].
  • The Center for Disease Control/American Thoracic Society (CDC/ATS) guidelines issued for the management of newly diagnosed cases of tuberculosis (TB) will not be totally effective regardless of adherence to the guidelines and patient cooperation [6].
  • A score (ATS) was calculated by summing the percent lumen narrowing of all main vessels; alcohol consumption was quantitated by questionnaire [7].

High impact information on SLC2A10


Chemical compound and disease context of SLC2A10

  • In univariate analysis, ATS was significantly (P< or = 0.001) associated with male sex, age, familial CVD, smoking, diabetes, hypertension, and serum cholesterol levels; alcohol consumption was associated with less frequent diabetes (P<0.001) and lower ATS (P = 0.02) [7].
  • Intrathecal ATS and high dosage diazepam in neonatal tetanus [12].

Biological context of SLC2A10


Anatomical context of SLC2A10


Associations of SLC2A10 with chemical compounds

  • A PROSITE search also shows that GLUT10 has lost the SUGAR TRANSPORT 2 pattern (PS00217), a result of the substitution G113S in TMD4, while all other known human GLUTs retain the glycine and the pattern match [18].
  • This advantage was maintained even when compared with 9 mo of isoniazid, the new American Thoracic Society/Centers for Disease Control (ATS/CDC) recommendation for treatment with isoniazid alone [21].
  • ATS guidelines for methacholine and exercise challenge testing [22].
  • All of these patients received ablative preparative treatment consisting of ATS (antithymocyte serum), cytoxan and either busulfan or TBI (total body irradiation) [23].
  • Sizes of the prostheses fitting the 21-mm valve holder were as follows: 18-mm ATS, 19-mm SJM Regent, 19-mm Sorin Bicarbon Slimline, 19-mm On-X, and 21-mm Carbomedics Top Hat [24].

Other interactions of SLC2A10


Analytical, diagnostic and therapeutic context of SLC2A10

  • By RT-PCR analysis, GLUT10 mRNA was also detected in fetal brain and liver [18].
  • The program was based on standardized procedures (ATS recommendations), performed by specifically trained and certified personnel; a fully-computerized spirometer with customized software was used for spirometry [26].
  • Recently, symptomatic reversal of DPN was reported after treatments with a near-infrared medical device, the Anodyne Therapy System (ATS) [19].
  • Care of the child with a chronic tracheostomy. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999 [27].
  • Intraoperative autotransfusion using the Bentley ATS 100 was used in 23 patients requiring Dacron replacement of their abdominal aorta [28].


  1. Coronary atherosclerosis in Type II diabetes: angiographic findings and clinical outcome. Natali, A., Vichi, S., Landi, P., Severi, S., L'Abbate, A., Ferrannini, E. Diabetologia (2000) [Pubmed]
  2. Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. Finder, J.D., Birnkrant, D., Carl, J., Farber, H.J., Gozal, D., Iannaccone, S.T., Kovesi, T., Kravitz, R.M., Panitch, H., Schramm, C., Schroth, M., Sharma, G., Sievers, L., Silvestri, J.M., Sterni, L. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  3. Chronic bird fancier's lung: histopathological and clinical correlation. An application of the 2002 ATS/ERS consensus classification of the idiopathic interstitial pneumonias. Ohtani, Y., Saiki, S., Kitaichi, M., Usui, Y., Inase, N., Costabel, U., Yoshizawa, Y. Thorax (2005) [Pubmed]
  4. The relationship between tumorigenicity, growth in agar and fibrinolytic activity in a line of human osteosarcoma cells. Jones, P.A., Rhim, J.S., Isaacs, H., McAllister, R.M. Int. J. Cancer (1975) [Pubmed]
  5. Ethnic differences in pulmonary function in healthy nonsmoking Asian-Americans and European-Americans. Korotzer, B., Ong, S., Hansen, J.E. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  6. Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies. Amaral, L., Kristiansen, J.E. Int. J. Antimicrob. Agents (2000) [Pubmed]
  7. Coronary atherosclerosis and alcohol consumption: angiographic and mortality data. Femia, R., Natali, A., L'Abbate, A., Ferrannini, E. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  8. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Coucke, P.J., Willaert, A., Wessels, M.W., Callewaert, B., Zoppi, N., De Backer, J., Fox, J.E., Mancini, G.M., Kambouris, M., Gardella, R., Facchetti, F., Willems, P.J., Forsyth, R., Dietz, H.C., Barlati, S., Colombi, M., Loeys, B., De Paepe, A. Nat. Genet. (2006) [Pubmed]
  9. Lysis of tumor biopsy cells by autologous T lymphocytes activated in mixed cultures and propagated with T cell growth factor. Vánky, F., Gorsky, T., Gorsky, Y., Masucci, M.G., Klein, E. J. Exp. Med. (1982) [Pubmed]
  10. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. Andersen, G., Rose, C.S., Hamid, Y.H., Drivsholm, T., Borch-Johnsen, K., Hansen, T., Pedersen, O. Diabetes (2003) [Pubmed]
  11. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. Lin, W.H., Chuang, L.M., Chen, C.H., Yeh, J.I., Hsieh, P.S., Cheng, C.H., Chen, Y.T. Diabetologia (2006) [Pubmed]
  12. Intrathecal ATS and high dosage diazepam in neonatal tetanus. Singhi, S., Singhi, P. Arch. Dis. Child. (1979) [Pubmed]
  13. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. Mohlke, K.L., Skol, A.D., Scott, L.J., Valle, T.T., Bergman, R.N., Tuomilehto, J., Boehnke, M., Collins, F.S. Mol. Genet. Metab. (2005) [Pubmed]
  14. Functional characterization of the promoter of the human glucose transporter 10 gene. Segade, F., Allred, D.C., Bowden, D.W. Biochim. Biophys. Acta (2005) [Pubmed]
  15. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. Bento, J.L., Bowden, D.W., Mychaleckyj, J.C., Hirakawa, S., Rich, S.S., Freedman, B.I., Segade, F. BMC Med. Genet. (2005) [Pubmed]
  16. Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. McVie-Wylie, A.J., Lamson, D.R., Chen, Y.T. Genomics (2001) [Pubmed]
  17. Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Wood, I.S., Hunter, L., Trayhurn, P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  18. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Dawson, P.A., Mychaleckyj, J.C., Fossey, S.C., Mihic, S.J., Craddock, A.L., Bowden, D.W. Mol. Genet. Metab. (2001) [Pubmed]
  19. Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. Leonard, D.R., Farooqi, M.H., Myers, S. Diabetes Care (2004) [Pubmed]
  20. Against the ATS statement on human embryonic stem cell research. Thomas, C.F., Vassallo, R., Castro, M. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  21. Twelve months of isoniazid compared with four months of isoniazid and rifampin for persons with radiographic evidence of previous tuberculosis: an outcome and cost-effectiveness analysis. Jasmer, R.M., Snyder, D.C., Chin, D.P., Hopewell, P.C., Cuthbert, S.S., Antonio Paz, E., Daley, C.L. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  22. ATS guidelines for methacholine and exercise challenge testing. Popa, V. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  23. Bone marrow transplantation for the Wiskott-Aldrich syndrome. Long-term follow-up. Rimm, I.J., Rappeport, J.M. Transplantation (1990) [Pubmed]
  24. Small aortic annulus: the hydrodynamic performances of 5 commercially available bileaflet mechanical valves. Bottio, T., Caprili, L., Casarotto, D., Gerosa, G. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  25. Identification of a novel glucose transporter-like protein-GLUT-12. Rogers, S., Macheda, M.L., Docherty, S.E., Carty, M.D., Henderson, M.A., Soeller, W.C., Gibbs, E.M., James, D.E., Best, J.D. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  26. Quality control of spirometry in the elderly. The SA.R.A. study. SAlute Respiration nell'Anziano = Respiratory Health in the Elderly. Bellia, V., Pistelli, R., Catalano, F., Antonelli-Incalzi, R., Grassi, V., Melillo, G., Olivieri, D., Rengo, F. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  27. Care of the child with a chronic tracheostomy. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Sherman, J.M., Davis, S., Albamonte-Petrick, S., Chatburn, R.L., Fitton, C., Green, C., Johnston, J., Lyrene, R.K., Myer, C., Othersen, H.B., Wood, R., Zach, M., Zander, J., Zinman, R. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  28. Intraoperative autotransfusion for elective aortic surgery. Greenhalgh, R.M., Kirk, C.J., Bartoll, A., Owen, J., Mitchell, T.R., Gerken, A., Master, B., Gregory, I.C. The British journal of surgery. (1978) [Pubmed]
WikiGenes - Universities