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Gene Review

CASK  -  calcium/calmodulin-dependent serine...

Homo sapiens

Synonyms: CAGH39, CAMGUK, CMG, Calcium/calmodulin-dependent serine protein kinase, FGS4, ...
 
 
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Disease relevance of CASK

  • Histological diagnoses were subdivided into keratosis without dysplasia (KWD), with mild dysplasia (LIN 1), with moderate dysplasia (LIN 2), and with severe dysplasia or carcinoma in situ (LIN 3) [1].
 

High impact information on CASK

  • Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells [2].
  • We detect in a yeast two-hybrid screen that the PDZ domain of hCASK binds to the heparan sulfate proteoglycan syndecan-2 [2].
  • LIN-2 belongs to the membrane-associated guanylate kinase family of proteins [2].
  • We have solved the solution structure of the heterodimer composed of the L27 domains from LIN-2 and LIN-7 [3].
  • Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes [4].
 

Biological context of CASK

  • Identical LOH patterns were determined in 100% of the LIN3 peritumoral cells, 60% of LIN2, 50% of LIN 1 and 25% of KWD [1].
 

Anatomical context of CASK

 

Associations of CASK with chemical compounds

  • Thirdly and more recently, a PDZ domain containing scaffolding protein CASK/Lin2 has been shown to interact with the PDZ binding motif of parkin [7].
  • LIN-7 is known to play an essential role in the basolateral localization of the LET-23 tyrosine kinase receptor, by linking the receptor to LIN-2 and LIN-10 proteins [8].
  • The recurrence rate after CO2 laser cordectomy was 16.6% for LIN 2 and 18.7% for LIN 3 [9].
 

Other interactions of CASK

  • We now report that hCASK binds another MAGUK, human discs large (hDlg) [5].
  • Among the cases of LIN unassociated with invasive carcinoma, DIN was present in 75% of LIN 1, 75% of LIN 2, and 66% of LIN 3 cases [10].
 

Analytical, diagnostic and therapeutic context of CASK

References

  1. 3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation. Sanz-Ortega, J., Valor, C., Saez, M.C., Ortega, L., Sierra, E., Poch, J., Hernández, S., Sanz-Esponera, J. Histol. Histopathol. (2003) [Pubmed]
  2. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. Cohen, A.R., Woods, D.F., Marfatia, S.M., Walther, Z., Chishti, A.H., Anderson, J.M., Wood, D.F. J. Cell Biol. (1998) [Pubmed]
  3. A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. Petrosky, K.Y., Ou, H.D., Löhr, F., Dötsch, V., Lim, W.A. J. Biol. Chem. (2005) [Pubmed]
  4. Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. Harris, B.Z., Venkatasubrahmanyam, S., Lim, W.A. J. Biol. Chem. (2002) [Pubmed]
  5. hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions. Nix, S.L., Chishti, A.H., Anderson, J.M., Walther, Z. J. Biol. Chem. (2000) [Pubmed]
  6. Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells. Martinez-Estrada, O.M., Villa, A., Breviario, F., Orsenigo, F., Dejana, E., Bazzoni, G. J. Biol. Chem. (2001) [Pubmed]
  7. Part I: parkin-associated proteins and Parkinson's disease. Dev, K.K., van der Putten, H., Sommer, B., Rovelli, G. Neuropharmacology (2003) [Pubmed]
  8. VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. Tseng, T.C., Marfatia, S.M., Bryant, P.J., Pack, S., Zhuang, Z., O'Brien, J.E., Lin, L., Hanada, T., Chishti, A.H. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Evolution of precancerous laryngeal lesions: a clinicopathologic study with long-term follow-up on 259 patients. Gallo, A., de Vincentiis, M., Della Rocca, C., Moi, R., Simonelli, M., Minni, A., Shaha, A.R. Head & neck. (2001) [Pubmed]
  10. Lobular intraepithelial neoplasia: previously unexplored aspects assessed in 775 cases and their clinical implications. Bratthauer, G.L., Tavassoli, F.A. Virchows Arch. (2002) [Pubmed]
 
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