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CD84  -  CD84 molecule

Homo sapiens

Synonyms: Cell surface antigen MAX.3, Hly9-beta, LY9B, Leukocyte differentiation antigen CD84, SLAM family member 5, ...
 
 
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High impact information on CD84

  • Expression and regulation of the SLAM-family receptors SLAM, CD84, and 2B4, as well as the lytic effectors perforin and granzyme-B are normal in SAP-deficient CTLs [1].
  • Here we show that the signaling pathways triggered during platelet aggregation include an intrinsic pro-thrombotic activity mediated by 2 homophilic adhesion molecules, CD84 and CD150 (SLAM [signaling lymphocyte activation molecule]), which are tyrosine phosphorylated in a platelet aggregation-dependent fashion [2].
  • Recruitment of SAP is most efficient when the specific tyrosine residues in the cytoplasmic tails of Ly-9 or CD84 are phosphorylated [3].
  • Interactions between SAP and Ly-9 or CD84 were analyzed using a novel yeast 2-hybrid system, by COS cell transfections and in lymphoid cells [3].
  • CD84 had a unique pattern of expression, being found predominantly on lymphocytes and monocytes [4].
 

Biological context of CD84

 

Anatomical context of CD84

 

Associations of CD84 with chemical compounds

  • CD84 was found to be rapidly tyrosine phosphorylated following receptor ligation on activated T cells, an event that involved the Src kinase Lck [5].
  • These MoAbs were further used to show that CD84 is expressed as a single chain cell-surface glycoprotein of Mr 64,000 to 82,000, which was highly glycosylated [4].
  • However, if cells are activated by the lectins PWM or ConA or by double-stranded RNA (polyinosinic-polycytidylic acid, pI:C), normal MAC maturation is suppressed: MO stay small and do not acquire MAC maturation-associated surface molecules like carboxypeptidase M (CPM, determined by antibody MAX.1) or CD84 (determined by antibody MAX.3) [9].
 

Regulatory relationships of CD84

 

Other interactions of CD84

  • Interestingly, although the Y54C and F87S mutations compromised the ability of SAP to associate with different receptors, the I84T mutation had no effect on the ability of SAP to bind SLAM, CD84 or 2B4 [11].
  • It is a 365-amino acid protein that belongs to the immunoglobulin-like superfamily with closest homology to murine 2B4, and human CD84 and CD48 [12].
  • Because receptor-ligand interactions occur between several members of this subfamily, we assayed CD84-Ig binding with all members of the CD2 family [13].
  • We show that the reagent used in previous studies, an anti-fractalkine N-terminal peptide antisera, cross-reacts with human CD84 [14].
  • Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue [15].
 

Analytical, diagnostic and therapeutic context of CD84

  • MAX.3/CD84 was further studied by immunohistochemistry and a variable expression was found on tissue MAC, confirming this antigen to be mainly a marker for MAC in situ [16].
  • RT-PCR was used to analyze CD84 mRNA isoforms [10].

References

  1. SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells. Dupré, L., Andolfi, G., Tangye, S.G., Clementi, R., Locatelli, F., Aricò, M., Aiuti, A., Roncarolo, M.G. Blood (2005) [Pubmed]
  2. Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. Nanda, N., Andre, P., Bao, M., Clauser, K., Deguzman, F., Howie, D., Conley, P.B., Terhorst, C., Phillips, D.R. Blood (2005) [Pubmed]
  3. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Sayós, J., Martín, M., Chen, A., Simarro, M., Howie, D., Morra, M., Engel, P., Terhorst, C. Blood (2001) [Pubmed]
  4. CD84 leukocyte antigen is a new member of the Ig superfamily. de la Fuente, M.A., Pizcueta, P., Nadal, M., Bosch, J., Engel, P. Blood (1997) [Pubmed]
  5. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. Tangye, S.G., Nichols, K.E., Hare, N.J., van de Weerdt, B.C. J. Immunol. (2003) [Pubmed]
  6. Molecular cloning, characterization, and chromosomal localization of the mouse homologue of CD84, a member of the CD2 family of cell surface molecules. de la Fuente, M.A., Tovar, V., Pizcueta, P., Nadal, M., Bosch, J., Engel, P. Immunogenetics (1999) [Pubmed]
  7. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Tangye, S.G., van de Weerdt, B.C., Avery, D.T., Hodgkin, P.D. Eur. J. Immunol. (2002) [Pubmed]
  8. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Romero, X., Benítez, D., March, S., Vilella, R., Miralpeix, M., Engel, P. Tissue Antigens (2004) [Pubmed]
  9. Activation of lymphocytes inhibits human monocyte to macrophage differentiation. Krause, S.W., Zaiss, M., Kreutz, M., Andreesen, R. Immunobiology (2001) [Pubmed]
  10. CD84 expression on human hematopoietic progenitor cells. Zaiss, M., Hirtreiter, C., Rehli, M., Rehm, A., Kunz-Schughart, L.A., Andreesen, R., Hennemann, B. Exp. Hematol. (2003) [Pubmed]
  11. Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP. Hare, N.J., Ma, C.S., Alvaro, F., Nichols, K.E., Tangye, S.G. Int. Immunol. (2006) [Pubmed]
  12. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. Kubin, M.Z., Parshley, D.L., Din, W., Waugh, J.Y., Davis-Smith, T., Smith, C.A., Macduff, B.M., Armitage, R.J., Chin, W., Cassiano, L., Borges, L., Petersen, M., Trinchieri, G., Goodwin, R.G. Eur. J. Immunol. (1999) [Pubmed]
  13. CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. Martin, M., Romero, X., de la Fuente, M.A., Tovar, V., Zapater, N., Esplugues, E., Pizcueta, P., Bosch, J., Engel, P. J. Immunol. (2001) [Pubmed]
  14. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Lucas, A.D., Chadwick, N., Warren, B.F., Jewell, D.P., Gordon, S., Powrie, F., Greaves, D.R. Am. J. Pathol. (2001) [Pubmed]
  15. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. Zhang, W., Wan, T., Li, N., Yuan, Z., He, L., Zhu, X., Yu, M., Cao, X. Clin. Cancer Res. (2001) [Pubmed]
  16. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. Krause, S.W., Rehli, M., Heinz, S., Ebner, R., Andreesen, R. Biochem. J. (2000) [Pubmed]
 
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