The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PLCZ1  -  phospholipase C, zeta 1

Homo sapiens

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, NYD-SP27, PLC-zeta-1, PLCzeta, Phosphoinositide phospholipase C-zeta-1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PLCZ1

 

High impact information on PLCZ1

  • We identify a novel, sperm-specific phospholipase C, PLC zeta, that triggers Ca(2+) oscillations in mouse eggs indistinguishable from those at fertilisation [2].
  • PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development [2].
  • Moreover, the PLC zeta content of a single sperm was sufficient to produce Ca(2+) oscillations as well as normal embryo development to blastocyst [2].
  • Those activities were analyzed by expressing PLCzeta mutants tagged with fluorescent protein Venus by injection of cRNA into unfertilized eggs or 1-cell embryos after fertilization [3].
  • Thus, PLCzeta is driven into the nucleus primarily by the aid of NLS and putative regulatory sites, but coordinated three-dimensional structure, possibly formed by a folding in the X/Y linker and close EF/C2 contact as in PLCdelta1, seems to be required not only for enzymatic activity but also for nuclear translocation ability [3].
 

Biological context of PLCZ1

  • Moreover, human PLCzeta elicits mouse egg activation and early embryonic development up to the blastocyst stage, and exhibits greater potency than PLCzeta from monkeys and mice [4].
  • The causative agent of these oscillations is proposed to be a recently described phosphoinositide-specific phospholipase C, PLCzeta, a soluble sperm protein that is delivered into the egg following membrane fusion [5].
  • These findings suggest that the synthesis of PLCzeta mRNA starts when spermiogenesis is initiated [6].
  • In the present study, porcine PLCzeta cDNA was identified and the nucleotide sequence was determined [6].
  • Although the roles of most components of the signal transduction pathway remain to be fully investigated, here I present a model in which a sperm-specific phospholipase C (PLCzeta) generates Ca(2+) spikes to activate calmodulin-dependent protein kinase II and so switch on the Anaphase-Promoting Complex/Cyclosome (APC/C) [7].
 

Anatomical context of PLCZ1

 

Other interactions of PLCZ1

  • INTERPRETATION: NYD-SP27 exerts an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function [1].
 

Analytical, diagnostic and therapeutic context of PLCZ1

References

  1. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. Zhu, H., Zhu, J.X., Lo, P.S., Li, J., Leung, K.M., Rowlands, D.K., Tsang, L.L., Yu, M.K., Jiang, J.L., Lam, S.Y., Chung, Y.W., Zhou, Z., Sha, J., Chang Chan, H. Lancet (2003) [Pubmed]
  2. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Saunders, C.M., Larman, M.G., Parrington, J., Cox, L.J., Royse, J., Blayney, L.M., Swann, K., Lai, F.A. Development (2002) [Pubmed]
  3. The Role of X/Y Linker Region and N-terminal EF-hand Domain in Nuclear Translocation and Ca2+ Oscillation-inducing Activities of Phospholipase C{zeta}, a Mammalian Egg-activating Factor. Kuroda, K., Ito, M., Shikano, T., Awaji, T., Yoda, A., Takeuchi, H., Kinoshita, K., Miyazaki, S. J. Biol. Chem. (2006) [Pubmed]
  4. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. Cox, L.J., Larman, M.G., Saunders, C.M., Hashimoto, K., Swann, K., Lai, F.A. Reproduction (2002) [Pubmed]
  5. PLCzeta, a sperm-specific PLC and its potential role in fertilization. Saunders, C.M., Swann, K., Lai, F.A. Biochem. Soc. Symp. (2007) [Pubmed]
  6. Molecular cloning, testicular postnatal expression, and oocyte-activating potential of porcine phospholipase C{zeta}. Yoneda, A., Kashima, M., Yoshida, S., Terada, K., Nakagawa, S., Sakamoto, A., Hayakawa, K., Suzuki, K., Ueda, J., Watanabe, T. Reproduction (2006) [Pubmed]
  7. Mammalian egg activation: from Ca2+ spiking to cell cycle progression. Jones, K.T. Reproduction (2005) [Pubmed]
  8. Calcium oscillations and mammalian egg activation. Malcuit, C., Kurokawa, M., Fissore, R.A. J. Cell. Physiol. (2006) [Pubmed]
  9. Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes. Rogers, N.T., Hobson, E., Pickering, S., Lai, F.A., Braude, P., Swann, K. Reproduction (2004) [Pubmed]
 
WikiGenes - Universities