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Gene Review

ECs3331  -  nitrate/nitrite sensor protein NarQ

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs3331


High impact information on ECs3331

  • Response to culture aeration mediated by the nitrate and nitrite sensor NarQ of Escherichia coli K-12 [4].
  • When nitrate is present, the NarX and NarQ sensor-transmitter proteins function to activate the response-regulator protein, NarL, which in turn binds to its DNA-recognition sites to modulate gene expression [5].
  • Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite [6].
  • Although both NarX and NarQ are known to detect the two environmental signals nitrate and nitrite, little is known regarding the sensitivity and selectivity of ligand for detection or activation of the sensor-transmitters [7].
  • NarX and NarQ each contain a conserved histidine residue that corresponds to the site of autophosphorylation of other sensor-transmitter proteins [8].

Chemical compound and disease context of ECs3331


Biological context of ECs3331


Associations of ECs3331 with chemical compounds

  • Thus, the NarQ sensor responds to aeration as well as to nitrate and nitrite [4].
  • The conserved histidine and asparagine residues are essential for NarX and NarQ function, and this suggests that other two-component sensor-transmitter proteins may function in a similar fashion [8].
  • Each protein transferred its phosphoryl group to purified NarL protein, although 'NarQ-phosphate catalyzed the transfer reaction at an apparently much faster rate than did 'NarX-phosphate [9].


  1. Coordinated Regulation of the Neisseria gonorrhoeae-truncated Denitrification Pathway by the Nitric Oxide-sensitive Repressor, NsrR, and Nitrite-insensitive NarQ-NarP. Overton, T.W., Whitehead, R., Li, Y., Snyder, L.A., Saunders, N.J., Smith, H., Cole, J.A. J. Biol. Chem. (2006) [Pubmed]
  2. Different responses to nitrate and nitrite by the model organism Escherichia coli and the human pathogen Neisseria gonorrhoeae. Whitehead, R.N., Cole, J.A. Biochem. Soc. Trans. (2006) [Pubmed]
  3. Biochemical Society Special Lecture. Nitrate- and nitrite-responsive sensors NarX and NarQ of proteobacteria. Stewart, V. Biochem. Soc. Trans. (2003) [Pubmed]
  4. Response to culture aeration mediated by the nitrate and nitrite sensor NarQ of Escherichia coli K-12. Stewart, V., Chen, L.L., Wu, H.C. Mol. Microbiol. (2003) [Pubmed]
  5. Role of the periplasmic domain of the Escherichia coli NarX sensor-transmitter protein in nitrate-dependent signal transduction and gene regulation. Cavicchioli, R., Chiang, R.C., Kalman, L.V., Gunsalus, R.P. Mol. Microbiol. (1996) [Pubmed]
  6. Fnr-, NarP- and NarL-dependent regulation of transcription initiation from the Haemophilus influenzae Rd napF (periplasmic nitrate reductase) promoter in Escherichia coli K-12. Stewart, V., Bledsoe, P.J. J. Bacteriol. (2005) [Pubmed]
  7. Signal-dependent phosphorylation of the membrane-bound NarX two-component sensor-transmitter protein of Escherichia coli: nitrate elicits a superior anion ligand response compared to nitrite. Lee, A.I., Delgado, A., Gunsalus, R.P. J. Bacteriol. (1999) [Pubmed]
  8. The NarX and NarQ sensor-transmitter proteins of Escherichia coli each require two conserved histidines for nitrate-dependent signal transduction to NarL. Cavicchioli, R., Schröder, I., Constanti, M., Gunsalus, R.P. J. Bacteriol. (1995) [Pubmed]
  9. Phosphorylation and dephosphorylation of the NarQ, NarX, and NarL proteins of the nitrate-dependent two-component regulatory system of Escherichia coli. Schröder, I., Wolin, C.D., Cavicchioli, R., Gunsalus, R.P. J. Bacteriol. (1994) [Pubmed]
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