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Gene Review

CD3G  -  CD3g molecule, gamma (CD3-TCR complex)

Homo sapiens

Synonyms: CD3-GAMMA, IMD17, T-cell receptor T3 gamma chain, T-cell surface glycoprotein CD3 gamma chain, T3G
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Disease relevance of CD3G

  • Several non-random translocation breakpoints associated with leukemia or lymphoma have been shown to occur in chromosome band 11q23 between the genes CD3G and PBGD, a distance of approximately 750 kb [1].
  • The molecular basis of the tissue-specific regulation of expression of the human CD3G and D genes were examined using DNase I hypersensitivity and CpG methylation analysis [2].

High impact information on CD3G

  • We recently showed that breakpoints in four 11q23 translocations, t(4;11)(q21;q23), t(6;11)(q27;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13.3), were contained within a yeast artificial chromosome clone bearing the CD3D and CD3G gene loci [3].
  • Furthermore, we show that a second 11q23 breakpoint, t(11;14)(q23;q32), which was also previously mapped between CD3G and PBGD, is distinct from that of the t(4;11) chromosome [1].
  • A combination of yeast artificial chromosome (YAC) cloning, in situ hybridization, and pulsed field gel electrophoresis (PFGE) experiments has further refined the interval containing one of these breakpoints, t(4;11)(q21;q23), to within 200 kb of CD3G [1].
  • A rearrangement of the CD3G gene has been observed in a cell line derived from a patient with the t(4;11) translocation and in a hybrid cell line containing the derivative 11q chromosome derived from this cell line, using the restriction enzymes SacII and ClaI [4].
  • Thus, we are able to localize such breakpoints, and consequently any affected candidate genes, to the 750 kb between CD3G and PBGD [5].

Biological context of CD3G


Anatomical context of CD3G

  • These results contrast with the partial T-cell immunodeficiency caused by a deficiency in CD3G [7].
  • We here show that, compared to fibroblasts from other anatomical locations, the capacity of cardiofibroblasts to secrete T4G and T3G is highest [11].
  • H9c2(2-1) myotubes, a model system for cardiomyocytes, take up T4G and T3G at a rate that is 10-15 times higher than that for the unconjugated thyroid hormones [11].
  • It may involve conjugation to the glucuronide forms (T4G and T3G) in the mucosal cell with subsequent deconjugation prior to appearance in the portal vein blood [12].

Associations of CD3G with chemical compounds

  • Rat cardiac fibroblasts produce and secrete glucuronidated thyroxine (T4G) and 3,3',5-triiodothyronine (T3G) [11].
  • This might have physiological significance for the tilapia, with T3G providing a reversible storage form of T3 in blood, as has been suggested for sulfate conjugates of T3 and T4 in blood of several mammals [9].


  1. Distinct breakpoints in band 11q23 of the t(4;11) and t(11;14) associated with leukocyte malignancy. Radice, P., Tunnacliffe, A. Genes Chromosomes Cancer (1992) [Pubmed]
  2. DNase hypersensitivity and methylation of the human CD3G and D genes during T-cell development. Flanagan, B.F., Wotton, D., Tuck-Wah, S., Owen, M.J. Immunogenetics (1990) [Pubmed]
  3. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Ziemin-van der Poel, S., McCabe, N.R., Gill, H.J., Espinosa, R., Patel, Y., Harden, A., Rubinelli, P., Smith, S.D., LeBeau, M.M., Rowley, J.D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. CD3G is within 200 kb of the leukemic t(4;11) translocation breakpoint. Das, S., Cotter, F.E., Gibbons, B., Dhut, S., Young, B.D. Genes Chromosomes Cancer (1991) [Pubmed]
  5. A physical linkage group in human chromosome band 11q23 covering a region implicated in leukocyte neoplasia. Tunnacliffe, A., McGuire, R.S. Genomics (1990) [Pubmed]
  6. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome. Rowley, J.D., Diaz, M.O., Espinosa, R., Patel, Y.D., van Melle, E., Ziemin, S., Taillon-Miller, P., Lichter, P., Evans, G.A., Kersey, J.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. CD3 deficiencies. Fischer, A., de Saint Basile, G., Le Deist, F. Current opinion in allergy and clinical immunology. (2005) [Pubmed]
  8. The transmembrane orientation of the epsilon chain of the TcR/CD3 complex. Clevers, H., Dunlap, S., Terhorst, C. Eur. J. Immunol. (1988) [Pubmed]
  9. 3,5,3'-Triiodothyronine (T3) clearance and T3-glucuronide (T3G) appearance kinetics in plasma of freshwater-reared male tilapia, Oreochromis mossambicus. DiStefano, J.J., Ron, B., Nguyen, T.T., Weber, G.M., Grau, E.G. Gen. Comp. Endocrinol. (1998) [Pubmed]
  10. Rapid and bacteria-dependent in vitro hydrolysis of iodothyronine-conjugates by intestinal contents of humans and rats. de Herder, W.W., Hazenberg, M.P., Pennock-Schröder, A.M., Hennemann, G., Visser, T.J. Med. Biol. (1986) [Pubmed]
  11. A physiological role for glucuronidated thyroid hormones: Preferential uptake by H9c2(2-1) myotubes. van der Heide, S.M., Joosten, B.J., Dragt, B.S., Everts, M.E., Klaren, P.H. Mol. Cell. Endocrinol. (2007) [Pubmed]
  12. Thyroid hormone and the gut. Hays, M.T. Endocr. Res. (1988) [Pubmed]
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