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MeSH Review


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Disease relevance of Lipectomy


High impact information on Lipectomy

  • BACKGROUND: The technique of tumescent liposuction involves the subcutaneous infusion of a solution containing lidocaine, followed by the aspiration of fat through microcannulas [1].
  • Presently, we examined insulin activation of glucose transport and signaling factors in cultured adipocytes derived from preadipocytes harvested during elective liposuction in lean and obese women [6].
  • Collectively, the lipectomy model appears useful for testing mechanisms controlling adiposity, or individual depot growth, and offers insight into how lipid stores fluctuate naturally [7].
  • The aim of the investigation was to assess the pharmacokinetic characteristics and safety of articaine HCl used in tumescent local anesthesia for liposuction [8].
  • Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes [9].

Biological context of Lipectomy


Anatomical context of Lipectomy


Associations of Lipectomy with chemical compounds

  • Maximum plasma concentrations of articaine HCl were observed from 136 to 264 ng/mL, on average, from 1.2 to 4.3 hours after the start of infiltration, depending on the area of liposuction [8].
  • Early management with hyaluronic acid, liposuction and saline washout of the extravasated fluid prevented development of any tissue damage [17].
  • In a prospective, double-blind, controlled study on 26 consecutive patients who underwent suction lipectomy, the injection of epinephrine (1:250,000, 1:500,000, or 1:1,000,000) was not found to decrease fluid/blood loss when compared with saline injection or no injection at all [18].
  • Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique [12].
  • The ratio of hemoglobin to triglyceride was lowest in the ultrasound-assisted group with (p = 0.01) and without (p = 0.06) the sheath when compared to traditional liposuction [19].

Gene context of Lipectomy

  • METHODS: Processed lipoaspirate cells extracted from human abdominal and buttock liposuction aspirates (n = 5) and from infrapatellar fat pads (n = 5) were placed in osteogenic media containing Dulbecco's Modified Eagle Medium with 10% fetal bovine serum supplemented with 50 muM ascorbic acid-2-phosphate and 10 mM beta-glycerol phosphate [20].
  • Adiponectin levels did not demonstrate any change with alteration in diet or liposuction [21].
  • Ghrelin levels decreased significantly and leptin levels demonstrated an increasing trend after liposuction [21].
  • In a preliminary study of 30 cases, treated with LANS-RH, the liposuction specimens were examined on hematoxylin & eosin (H&E)-stained step sections and at immunohistochemical levels, using the antibody cocktails MNF 116 and AE1/AE3 for cytokeratins to detect occult tumor cells [22].
  • Insulin-induced lipohypertrophy ('insulin tumours') can be treated successfully with liposuction [23].

Analytical, diagnostic and therapeutic context of Lipectomy


  1. Deaths related to liposuction. Rao, R.B., Ely, S.F., Hoffman, R.S. N. Engl. J. Med. (1999) [Pubmed]
  2. Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Laffon, M., Jayr, C., Barbry, P., Wang, Y., Folkesson, H.G., Pittet, J.F., Clerici, C., Matthay, M.A. Anesthesiology (2002) [Pubmed]
  3. Treatment of exogenous steroid-induced "buffalo-type" facial and neck obesity with suction lipectomy. La Trenta, G.S., Grant, R.T., Hoffman, L.A. Plast. Reconstr. Surg. (1991) [Pubmed]
  4. Prilocaine plasma levels and methemoglobinemia in patients undergoing tumescent liposuction involving less than 2,000 ml. Lindenblatt, N., Belusa, L., Tiefenbach, B., Schareck, W., Olbrisch, R.R. Aesthetic plastic surgery. (2004) [Pubmed]
  5. Hypersensitivity dermatitis following suction-assisted lipectomy: a complication of local anesthetic. Fine, P.G., Dingman, D.L. Annals of plastic surgery. (1988) [Pubmed]
  6. Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects. Sajan, M.P., Standaert, M.L., Miura, A., Bandyopadhyay, G., Vollenweider, P., Franklin, D.M., Lea-Currie, R., Farese, R.V. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  7. The regulation of total body fat: lessons learned from lipectomy studies. Mauer, M.M., Harris, R.B., Bartness, T.J. Neuroscience and biobehavioral reviews. (2001) [Pubmed]
  8. Pharmacokinetics of articaine hydrochloride in tumescent local anesthesia for liposuction. Grossmann, M., Sattler, G., Pistner, H., Oertel, R., Richter, K., Schinzel, S., Jacobs, L.D. Journal of clinical pharmacology. (2004) [Pubmed]
  9. Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes. Harris, R.B., Hausman, D.B., Bartness, T.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  10. Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study. Kenkel, J.M., Lipschitz, A.H., Shepherd, G., Armstrong, V.W., Streit, F., Oellerich, M., Luby, M., Rohrich, R.J., Brown, S.A. Plast. Reconstr. Surg. (2004) [Pubmed]
  11. Norepinephrine turnover in brown and white adipose tissue after partial lipectomy. Shi, H., Bowers, R.R., Bartness, T.J. Physiol. Behav. (2004) [Pubmed]
  12. Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique. Samdal, F., Mollnes, T.E., Amland, P.F., Truedsson, L. Plast. Reconstr. Surg. (1997) [Pubmed]
  13. The fate of hypodermis after liposuction surgery. Piérard-Franchimont, C., Damseaux, M., Mélotte, P., Piérard, G.E. J. Am. Acad. Dermatol. (1988) [Pubmed]
  14. The effects of surgically removing subcutaneous fat on the metabolic profile and insulin sensitivity in obese women after large-volume liposuction treatment. González-Ortiz, M., Robles-Cervantes, J.A., Cárdenas-Camarena, L., Bustos-Saldaña, R., Martínez-Abundis, E. Horm. Metab. Res. (2002) [Pubmed]
  15. Breast milk lidocaine levels in tumescent liposuction. Dryden, R.M., Lo, M.W. Plast. Reconstr. Surg. (2000) [Pubmed]
  16. Metabolic modulation by lipoplasty: a case report and invitation for investigators. Ersek, R.A., Salisbury, M., Girling V, R. Aesthetic plastic surgery. (2004) [Pubmed]
  17. Use of liposuction and saline washout for the treatment of extensive subcutaneous extravasation of corrosive drugs. Martin, P.H., Carver, N., Petros, A.J. British journal of anaesthesia. (1994) [Pubmed]
  18. The effect of epinephrine on blood loss during suction lipectomy. Courtiss, E.H., Kanter, M.A., Kanter, W.R., Ransil, B.J. Plast. Reconstr. Surg. (1991) [Pubmed]
  19. The tissue effects of ultrasound-assisted lipoplasty. Kenkel, J.M., Robinson, J.B., Beran, S.J., Tan, J., Howard, B.K., Zocchi, M.L., Rohrich, R.J. Plast. Reconstr. Surg. (1998) [Pubmed]
  20. Tissue-engineered bone from BMP-2-transduced stem cells derived from human fat. Dragoo, J.L., Lieberman, J.R., Lee, R.S., Deugarte, D.A., Lee, Y., Zuk, P.A., Hedrick, M.H., Benhaim, P. Plast. Reconstr. Surg. (2005) [Pubmed]
  21. The effect of liposuction and diet on ghrelin, adiponectin, and leptin levels in obese Zucker rats. Schreiber, J.E., Singh, N.K., Shermak, M.A. Plast. Reconstr. Surg. (2006) [Pubmed]
  22. Occult tumor cells in surgical specimens from cases of early cervical cancer treated by liposuction-assisted nerve-sparing radical hysterectomy. Horn, L.C., Fischer, U., Höckel, M. Int. J. Gynecol. Cancer (2001) [Pubmed]
  23. Diabetic lipohypertrophy treated with suction-assisted lipectomy. Samdal, F., Amland, P.F., Sandsmark, M., Birkeland, K.I. J. Intern. Med. (1993) [Pubmed]
  24. Plasma lidocaine levels during augmentation mammaplasty and suction-assisted lipectomy. Gumucio, C.A., Bennie, J.B., Fernando, B., Young, V.L., Roa, N., Kraemer, B.A. Plast. Reconstr. Surg. (1989) [Pubmed]
  25. Flap perfusion mapping: TRAM flap after abdominal suction-assisted lipectomy. May, J.W., Silverman, R.P., Kaufman, J.A. Plast. Reconstr. Surg. (1999) [Pubmed]
  26. Perioperative management of cosmetic liposuction. de Jong, R.H., Grazer, F.M. Plast. Reconstr. Surg. (2001) [Pubmed]
  27. Surgical treatment of the aging neck. Kamer, F.M., Pieper, P.G. Facial plastic surgery : FPS. (2001) [Pubmed]
  28. Tumescent technique for regional anesthesia permits lidocaine doses of 35 mg/kg for liposuction. Klein, J.A. The Journal of dermatologic surgery and oncology. (1990) [Pubmed]
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