Disease relevance of Lipectomy

• CONCLUSIONS: Tumescent liposuction can be fatal, perhaps in part because of lidocaine toxicity or lidocaine-related drug interactions [1].
• BACKGROUND: Lidocaine is widely used in patients with acute cardiac disorders and has also been recently implicated as a possible cause of pulmonary edema after liposuction [2].
• Treatment of exogenous steroid-induced "buffalo-type" facial and neck obesity with suction lipectomy [3].
• METHODS: In 25 patients undergoing liposuction involving less than 2,000 ml prilocaine levels and methemoglobinemia were measured over 4 h postoperatively [4].
• We report a case of severe dermatitis involving the abdomen and thighs following suction-assisted lipectomy of these areas wherein local anesthetic containing the preservative methylparaben was used for infiltrative anesthesia [5].

High impact information on Lipectomy

• BACKGROUND: The technique of tumescent liposuction involves the subcutaneous infusion of a solution containing lidocaine, followed by the aspiration of fat through microcannulas [1].
• Presently, we examined insulin activation of glucose transport and signaling factors in cultured adipocytes derived from preadipocytes harvested during elective liposuction in lean and obese women [6].
• Collectively, the lipectomy model appears useful for testing mechanisms controlling adiposity, or individual depot growth, and offers insight into how lipid stores fluctuate naturally [7].
• The aim of the investigation was to assess the pharmacokinetic characteristics and safety of articaine HCl used in tumescent local anesthesia for liposuction [8].
• Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes [9].

Biological context of Lipectomy

• Pharmacokinetics and safety of lidocaine and monoethylglycinexylidide in liposuction: a microdialysis study [10].
• Total dissected WAT, and inguinal and retroperitoneal WAT masses were significantly increased following lipectomy, whereas dorsal subcutaneous WAT and IBAT masses, as well as food intake, were unchanged [11].
• We conclude that liposuction with the present techniques results in a very modest release of adipsin/factor D that is not associated with increased complement activation [12].

Anatomical context of Lipectomy

• With histologic, morphometric, and autoradiographic examination and the use of tritiated thymidine, uridine, and proline, we have studied the fate of adipose tissue at various intervals after liposuction; however, we have never seen a reparative proliferation of the residual lipocytes [13].
• In conclusion, surgical removal of subcutaneous fat by large-volume liposuction led to an improvement in insulin sensitivity and a decrease in glucose and uric acid concentrations [14].
• Breast milk lidocaine levels in tumescent liposuction [15].
• Metabolic modulation refers to the change in glucose metabolism that may be caused by the reduction in body fat after large-volume liposuction [16].

Associations of Lipectomy with chemical compounds

• Maximum plasma concentrations of articaine HCl were observed from 136 to 264 ng/mL, on average, from 1.2 to 4.3 hours after the start of infiltration, depending on the area of liposuction [8].
• Early management with hyaluronic acid, liposuction and saline washout of the extravasated fluid prevented development of any tissue damage [17].
• In a prospective, double-blind, controlled study on 26 consecutive patients who underwent suction lipectomy, the injection of epinephrine (1:250,000, 1:500,000, or 1:1,000,000) was not found to decrease fluid/blood loss when compared with saline injection or no injection at all [18].
• Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique [12].
• The ratio of hemoglobin to triglyceride was lowest in the ultrasound-assisted group with (p = 0.01) and without (p = 0.06) the sheath when compared to traditional liposuction [19].

Gene context of Lipectomy

• METHODS: Processed lipoaspirate cells extracted from human abdominal and buttock liposuction aspirates (n = 5) and from infrapatellar fat pads (n = 5) were placed in osteogenic media containing Dulbecco's Modified Eagle Medium with 10% fetal bovine serum supplemented with 50 muM ascorbic acid-2-phosphate and 10 mM beta-glycerol phosphate [20].
• Adiponectin levels did not demonstrate any change with alteration in diet or liposuction [21].
• Ghrelin levels decreased significantly and leptin levels demonstrated an increasing trend after liposuction [21].
• In a preliminary study of 30 cases, treated with LANS-RH, the liposuction specimens were examined on hematoxylin & eosin (H&E)-stained step sections and at immunohistochemical levels, using the antibody cocktails MNF 116 and AE1/AE3 for cytokeratins to detect occult tumor cells [22].
• Insulin-induced lipohypertrophy ('insulin tumours') can be treated successfully with liposuction [23].

Analytical, diagnostic and therapeutic context of Lipectomy

• Plasma lidocaine levels during augmentation mammaplasty and suction-assisted lipectomy [24].
• Flap perfusion mapping: TRAM flap after abdominal suction-assisted lipectomy [25].
• In fact, ASPS guidelines urge that anesthesia services be engaged for dedicated patient care whenever "major" liposuction or conscious sedation is projected, because liposuction is neither as benign nor as simple a procedure as heretofore reputed [26].
• Depending upon the specific findings, any combination of a group of procedures may be required, including cervical rhytidectomy, submental suction-assisted lipectomy, chin augmentation, and midline imbrication of the platysma muscles [27].
• Tumescent technique for regional anesthesia permits lidocaine doses of 35 mg/kg for liposuction [28].

References