The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

MEGX     N-(2,6-dimethylphenyl)-2- ethylamino...

Synonyms: Norlidocaine, Nor Lidocaine, CHEMBL1028, L-86, SureCN1232491, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-Ethylglycinexylidide


Psychiatry related information on N-Ethylglycinexylidide


High impact information on N-Ethylglycinexylidide


Chemical compound and disease context of N-Ethylglycinexylidide


Biological context of N-Ethylglycinexylidide


Anatomical context of N-Ethylglycinexylidide


Associations of N-Ethylglycinexylidide with other chemical compounds


Gene context of N-Ethylglycinexylidide


Analytical, diagnostic and therapeutic context of N-Ethylglycinexylidide


  1. Assessment of lidocaine metabolite formation as a quantitative liver function test in children. Gremse, D.A., A-Kader, H.H., Schroeder, T.J., Balistreri, W.F. Hepatology (1990) [Pubmed]
  2. Predictors of one-year pretransplant survival in patients with cirrhosis. Oellerich, M., Burdelski, M., Lautz, H.U., Binder, L., Pichlmayr, R. Hepatology (1991) [Pubmed]
  3. Effects of chronic renal failure and hemodialysis on the monoethylglycinexylidide liver function test. Palatini, P., Floreani, M., Padrini, R., Piccoli, P., Bertoli, M., Calò, L., Orlando, R. Clin. Chem. (2000) [Pubmed]
  4. Omeprazole decreased formation of monoethylglycinexylidide in a patient with chronic active hepatitis. Campo, N., Alvarez, S., Borzone, S., Caglieris, S., Zentilin, P., Testa, R. Am. J. Gastroenterol. (1994) [Pubmed]
  5. The monoethylglycinexylidide test for grading of liver cirrhosis. Fabris, L., Jemmolo, R.M., Toffolo, G., Paleari, D., Viaggi, S., Rigon, M., Casagrande, F., Lirussi, F., Strazzabosco, M., Cobelli, C., Okolicsanyi, L. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  6. The MEGX test: a tool for the real-time assessment of hepatic function. Oellerich, M., Armstrong, V.W. Therapeutic drug monitoring. (2001) [Pubmed]
  7. The monoethylglycinexylidide test does not impair psychometric performance in patients with chronic hepatitis or cirrhosis. Botta, F., Giannini, E., Fasoli, A., Romagnoli, P., Risso, D., Testa, R. Therapeutic drug monitoring. (2000) [Pubmed]
  8. The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat. Leclercq, I., Saliez, A., Wallemacq, P.E., Horsmans, Y., Lambotte, L. Hepatology (1997) [Pubmed]
  9. Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. Cakaloglu, Y., Tredger, J.M., Devlin, J., Williams, R. Hepatology (1994) [Pubmed]
  10. Effect of hypoxia on the hepatic metabolism of lidocaine in the isolated perfused pig liver. Mets, B., Hickman, R., Allin, R., Van Dyk, J., Lotz, Z. Hepatology (1993) [Pubmed]
  11. Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2. Hanna, I.H., Roberts, E.S., Hollenberg, P.F. Biochemistry (1998) [Pubmed]
  12. Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions. Wieland, E., Schütz, E., Armstrong, V.W., Küthe, F., Heller, C., Oellerich, M. Transplantation (1995) [Pubmed]
  13. Determination of monoethylglycinexylidide by fluorescence polarization immunoassay in highly icteric serum samples: modified precipitation procedure and HPLC compared. Schütz, E., Shipkova, M., Niedmann, P.D., Wieland, E., Armstrong, V.W., Oellerich, M. Clin. Chem. (1998) [Pubmed]
  14. Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits. Chamelian, M., Lécrivain, A., Robichaud, A., du Souich, P. Br. J. Pharmacol. (1994) [Pubmed]
  15. 13CO2 excretion in breath of normal subjects and cirrhotic patients after 13C-aminopyrine oral load. Comparison with MEGX test in functional differentiation between chronic hepatitis and liver cirrhosis. Fasoli, A., Giannini, E., Botta, F., Romagnoli, P., Risso, D., Celle, G., Testa, R. Hepatogastroenterology (2000) [Pubmed]
  16. Monoethylglycinexylidide formation kinetics: a novel approach to assessment of liver function. Oellerich, M., Raude, E., Burdelski, M., Schulz, M., Schmidt, F.W., Ringe, B., Lamesch, P., Pichlmayr, R., Raith, H., Scheruhn, M. J. Clin. Chem. Clin. Biochem. (1987) [Pubmed]
  17. Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients. Kern, H., Schröder, T., Kaulfuss, M., Martin, M., Kox, W.J., Spies, C.D. Crit. Care Med. (2001) [Pubmed]
  18. Effect of phenobarbital on the pharmacokinetics of lidocaine, monoethylglycinexylidide and 3-hydroxylidocaine in the rat: correlation with P450 isoform levels. Nakamoto, T., Oda, Y., Imaoka, S., Funae, Y., Fujimori, M. Drug Metab. Dispos. (1997) [Pubmed]
  19. Long-term follow up of chronic hepatitis C patients after alpha-interferon treatment: a functional study. Giannini, E., Fasoli, A., Botta, F., Testa, E., Romagnoli, P., Ceppa, P., Testa, R. J. Gastroenterol. Hepatol. (2001) [Pubmed]
  20. Monoethylglycinexylidide production and prediction of hepatic histology. Fabbri, A., Bianchi, G.P., Marchesini, G. The Italian journal of gastroenterology. (1995) [Pubmed]
  21. Metabolism of lidocaine by rat pulmonary cytochrome P450. Tanaka, K., Oda, Y., Asada, A., Fujimori, M., Funae, Y. Biochem. Pharmacol. (1994) [Pubmed]
  22. Lidocaine, monoethylglycinexylidide, and isolated human uterine muscle. Munson, E.S., Embro, W.J. Anesthesiology (1978) [Pubmed]
  23. Pharmacokinetics of lidocaine and its major metabolite- monoethylglycinexylidide (MEGX) in rabbits with experimental common bile duct obstruction. Wójcicki, J., Sulikowski, T., Wójcicki, M., Droździk, M., Gawrońska-Szklarz, B., Barcew-Wiszniewska, B., Skowron, J., Rózewicka, L., Gołdyn, U. European journal of drug metabolism and pharmacokinetics. (1995) [Pubmed]
  24. Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. Imaoka, S., Enomoto, K., Oda, Y., Asada, A., Fujimori, M., Shimada, T., Fujita, S., Guengerich, F.P., Funae, Y. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  25. Plasma lidocaine concentrations during continuous thoracic epidural anesthesia after clonidine premedication in children. Inomata, S., Tanaka, E., Miyabe, M., Kakiuchi, Y., Nagashima, A., Yamasaki, Y., Nakayama, S., Baba, Y., Toyooka, H., Okuyama, K., Kohda, Y. Anesth. Analg. (2001) [Pubmed]
  26. The viability of liver graft for transplantation after prolonged warm ischaemia. Ong, H.S., Soo, K.C., Joseph, V.T., Tan, S.Y., Jeyaraj, P.R. Ann. Acad. Med. Singap. (1999) [Pubmed]
  27. Rifampicin induction of lidocaine metabolism in cultured human hepatocytes. Li, A.P., Rasmussen, A., Xu, L., Kaminski, D.L. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  28. Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of the monoethylglycinexylidide test. Huang, Y.S., Chiang, J.H., Wu, J.C., Chang, F.Y., Lee, S.D. Am. J. Gastroenterol. (2002) [Pubmed]
  29. Does age affect liver function and the hepatic acute phase response after major abdominal surgery? Suttner, S.W., Sürder, C., Lang, K., Piper, S.N., Kumle, B., Boldt, J. Intensive care medicine. (2001) [Pubmed]
  30. Monoethylglycinexylidide (MEGX) liver function test is not compromised by 3-hydroxy MEGX in humans. Schütz, E., Shipkova, M., Armstrong, V.W., Oellerich, M. Hepatology (1998) [Pubmed]
  31. A quick, sensitive high-performance liquid chromatography assay for monoethylglycinexylidide and lignocaine in serum/plasma using solid-phase extraction. Chen, Y., Potter, J.M., Ravenscroft, P.J. Therapeutic drug monitoring. (1992) [Pubmed]
WikiGenes - Universities