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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Paramecium


High impact information on Paramecium

  • We propose that these codons do not represent termination codons in P. primaurelia but instead code for glutamic acid or glutamine and that the in vitro translation of Paramecium mRNAs is blocked by their presence [6].
  • In contrast, 170 atmospheres did not significantly affect swimming behavior of paramecium "models" that were reactivated in a solution containing adenosine triphosphate and magnesium ions after their membrane had been disrupted by Triton X-100 [7].
  • In addition, an essential function of gamma-tubulin in basal body duplication has been demonstrated in Paramecium [8].
  • We cloned a guanylyl cyclase of 280 kDa from the ciliate Paramecium which has an N-terminus similar to that of a P-type ATPase and a C-terminus with a topology identical to mammalian adenylyl cyclases [9].
  • This dynein was directly compared with the axonemal dyneins from Paramecium and found to differ by five criteria: morphology, sedimentation coefficient, CTPase/ATPase ratio, vanadate cleavage patterns, and polypeptide composition [10].

Chemical compound and disease context of Paramecium


Biological context of Paramecium


Anatomical context of Paramecium


Associations of Paramecium with chemical compounds

  • Genetic analysis of membrane differentiation in Paramecium. Freeze-fracture study of the trichocyst cycle in wild-type and mutant strains [22].
  • Membrane vesicles with a high mating reactivity were obtained from cilia of Paramecium caudatum by treatment with a solution containing 2 M urea and 0.1 mM Na2-EDTA [23].
  • The action of deoxyribonuclease, ribonuclease, perchloric acid, and pronase on the fine structure of basal bodies of sectioned Paramecium was observed as part of a more extensive autoradiographic electron microscope analysis directed toward the problem of basal body DNA [24].
  • Based on a previous observation that the naphthalene sulfonamide calmodulin antagonist W-7 can block Paramecium Ca channels at high concentration, we have synthesized analogs of W-7 that block these channels at concentrations of less than 1 microM [25].
  • 5-Azacytidine affects the programming of expression of the somatic nucleus of Paramecium [26].

Gene context of Paramecium


Analytical, diagnostic and therapeutic context of Paramecium

  • Finally, synthesis and release of GABA in the environment by Paramecium have been demonstrated by HPLC [31].
  • Immunofluorescence assays showed the reactivity of anti-Pf9-peptide sera with P. falciparum merozoites and gametocytes, as well as on the surface of Paramecium tetraurelia [32].
  • Ultrastructure and antigenicity of the "mesh-like sheath" (MLS), a very delicate structure connecting the membrane and the paracrystalline matrix of Paramecium trichocysts, are well preserved after cryofixation (rapid freezing followed by freeze-substitution in methanol and embedding in Lowicryl K11M at 213K) [33].
  • Polystyrene fluorescent microspheres and a variety of mithramycin stained biological samples ranging from yeast cells to Paramecium were processed by the system [34].
  • In this study we report evidence of recombination of p29 to cytoplasmic dyneins from both rat liver and Paramecium, as well as to a 22S dynein precursor molecule, based on immunoprecipitation and force filtration data [35].


  1. Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1. McCullough, A.K., Romberg, M.T., Nyaga, S., Wei, Y., Wood, T.G., Taylor, J.S., Van Etten, J.L., Dodson, M.L., Lloyd, R.S. J. Biol. Chem. (1998) [Pubmed]
  2. Isolation and characterization of macronuclei of Paramecium caudatum infected with the macronucleus-specific bacterium Holospora obtusa. Freiburg, M. J. Cell. Sci. (1985) [Pubmed]
  3. Altered genetic code in Paramecium mitochondria: possible evolutionary trends. Seilhamer, J.J., Cummings, D.J. Mol. Gen. Genet. (1982) [Pubmed]
  4. Evaluation of carbamate toxicity: acute toxicity in a culture of Paramecium multimicronucleatum upon exposure to aldicarb, carbaryl, and mexacarbate as measured by Warburg respirometry and acute plate assay. Edmiston, C.E., Goheen, M., Malaney, G.W., Mills, W.L. Environmental research. (1985) [Pubmed]
  5. G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia. de Ondarza, J., Symington, S.B., Van Houten, J.L., Clark, J.M. J. Eukaryot. Microbiol. (2003) [Pubmed]
  6. Does Paramecium primaurelia use a different genetic code in its macronucleus? Caron, F., Meyer, E. Nature (1985) [Pubmed]
  7. Hydrostatic pressure reversibly blocks membrane control of ciliary motility in Paramecium. Otter, T., Salmon, E.D. Science (1979) [Pubmed]
  8. gamma-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Schiebel, E. Curr. Opin. Cell Biol. (2000) [Pubmed]
  9. Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. Linder, J.U., Engel, P., Reimer, A., Krüger, T., Plattner, H., Schultz, A., Schultz, J.E. EMBO J. (1999) [Pubmed]
  10. Vesicle transport along microtubular ribbons and isolation of cytoplasmic dynein from Paramecium. Schroeder, C.C., Fok, A.K., Allen, R.D. J. Cell Biol. (1990) [Pubmed]
  11. Nocodazole inhibits macronuclear infection with Holospora obtusa in Paramecium caudatum. Sabaneyeva, E.V., Fokin, S.I., Gavrilova, E.V., Kornilova, E.S. Protoplasma (2005) [Pubmed]
  12. Toxicity of Fastac 10 EC, a pyrethroid insecticide, to Paramecium primaurelia and Tubifex sp. Komala, Z. Folia biologica. (1992) [Pubmed]
  13. Processing of double-strand breaks is involved in the precise excision of paramecium internal eliminated sequences. Gratias, A., Bétermier, M. Mol. Cell. Biol. (2003) [Pubmed]
  14. Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1. Graziani, S., Xia, Y., Gurnon, J.R., Van Etten, J.L., Leduc, D., Skouloubris, S., Myllykallio, H., Liebl, U. J. Biol. Chem. (2004) [Pubmed]
  15. The vacuolar proton-ATPase plays a major role in several membrane-bounded organelles in Paramecium. Wassmer, T., Froissard, M., Plattner, H., Kissmehl, R., Cohen, J. J. Cell. Sci. (2005) [Pubmed]
  16. Effects of the plant amino acid mimosine on cell division, DNA, RNA and protein syntheses in Paramecium. Reisner, A.H., Bucholtz, C.A., Ward, K.A. Mol. Pharmacol. (1979) [Pubmed]
  17. AMP-dependence of the cyanide-insensitive pathway in the respiratory chain of Paramecium tetraurelia. Doussière, J., Vignais, P.V. Biochem. J. (1984) [Pubmed]
  18. Characterization of mitochondrial and cytoplasmic ribosomes from Paramecium aurelia. Tait, A., Knowles, J.K. J. Cell Biol. (1977) [Pubmed]
  19. Calcium/calmodulin-regulated guanylate cyclase of the excitable ciliary membrane from Paramecium. Dissociation of calmodulin by La3+: calmodulin specificity and properties of the reconstituted guanylate cyclase. Klumpp, S., Kleefeld, G., Schultz, J.E. J. Biol. Chem. (1983) [Pubmed]
  20. Ca(2+)-binding proteins of cilia and infraciliary lattice of Paramecium tetraurelia: their phosphorylation by purified endogenous Ca(2+)-dependent protein kinases. Kim, K., Son, M., Peterson, J.B., Nelson, D.L. J. Cell. Sci. (2002) [Pubmed]
  21. The in vivo effect of dimethyl sulphoxide (DMSO) on protein synthesis and the polyribosome profile in Paramecium. Reisner, A.H., Bucholtz, C. J. Cell. Physiol. (1977) [Pubmed]
  22. Genetic analysis of membrane differentiation in Paramecium. Freeze-fracture study of the trichocyst cycle in wild-type and mutant strains. Beisson, J., Lefort-Tran, M., Pouphile, M., Rossignol, M., Satir, B. J. Cell Biol. (1976) [Pubmed]
  23. Mating-reactive membrane vesicles from cilia of Paramecium caudatum. Kitamura, A., Hiwatashi, K. J. Cell Biol. (1976) [Pubmed]
  24. Effects of nuclease and protease digestion on the ultrastructure of Paramecium basal bodies. Dippell, R.V. J. Cell Biol. (1976) [Pubmed]
  25. Paramecium calcium channels are blocked by a family of calmodulin antagonists. Ehrlich, B.E., Jacobson, A.R., Hinrichsen, R., Sayre, L.M., Forte, M.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  26. 5-Azacytidine affects the programming of expression of the somatic nucleus of Paramecium. Kwok, F.W., Ng, S.F. Development (1989) [Pubmed]
  27. Comparative modeling of the three-dimensional structure of the calmodulin-related TCH2 protein from Arabidopsis. Khan, A.R., Johnson, K.A., Braam, J., James, M.N. Proteins (1997) [Pubmed]
  28. A novel member of the cyclin-dependent kinase family in Paramecium tetraurelia. Zhang, H., Berger, J.D. J. Eukaryot. Microbiol. (1999) [Pubmed]
  29. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. Creutz, C.E., Tomsig, J.L., Snyder, S.L., Gautier, M.C., Skouri, F., Beisson, J., Cohen, J. J. Biol. Chem. (1998) [Pubmed]
  30. A comparative hybridization analysis of yeast DNA with Paramecium parafusin- and different phosphoglucomutase-specific probes. Wyroba, E., Satir, B.H. Biochem. Cell Biol. (2000) [Pubmed]
  31. Swimming behavior regulation by GABAB receptors in Paramecium. Ramoino, P., Fronte, P., Beltrame, F., Diaspro, A., Fato, M., Raiteri, L., Stigliani, S., Usai, C. Exp. Cell Res. (2003) [Pubmed]
  32. A protective merozoite protein of Plasmodium falciparum shares an epitope with surface antigens of Paramecium. Sehgal, A., Singh, N.J., Chakraborty, T., Sharma, S. Parasite Immunol. (2004) [Pubmed]
  33. Ultrastructural and antigenic preservation of a delicate structure by cryopreparation: identification and immunogold localization during biogenesis of a secretory component (membrane-matrix connection) in Paramecium trichocysts. Momayezi, M., Habermann, A.W., Sokolova, J.J., Kissmehl, R., Plattner, H. J. Histochem. Cytochem. (1993) [Pubmed]
  34. Simple adaptations to extend the range of flow cytometry five orders of magnitude for the DNA analysis of uni-and multicellular systems. Hecht, R.M., Schomer, D.F., Oró, J.A., Bartel, A.H., Hungerford, E.V. J. Histochem. Cytochem. (1981) [Pubmed]
  35. The 29 kDa light chain that regulates axonemal dynein activity binds to cytoplasmic dyneins. Wang, H., Satir, P. Cell Motil. Cytoskeleton (1998) [Pubmed]
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