Your search matched a total of 5636 documents. Results 1 - 10.
Rattus norvegicus
Gene: ... , whereas Pep- B failed to bind at all. BACKGROUND: C5a has been implicated in numerous pathophysiological...Disease relevance of C5 Thus, C5a alone appears to have only a limited role in the induction of liver fibrosis. These results suggest that C5a, besides enhancing glucose output via prostanoids... / Synonyms: C5a; Complement C5
Homo sapiens
Gene: ... is specific and involves a single C5 binding site located on the beta- subunit of C8. Direct sequencing of all...Disease relevance of C5 Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. We have analyzed the role of complement component C5 in experimental autoimmune... / Synonyms: C5D; C5a; C5b
Ovis aries
Gene: ... Disease relevance of C5aR Preferential suppression of delayed- type hypersensitivity by L- 156, 602, a C5a receptor antagonist. High impact information on C5aR The cyclic C5a receptor antagonist... approximately 1000- fold less affinity for the C5a receptor( C5aR) on murine polymorphonuclear leukocytes than...
Rattus norvegicus
Gene: ... Disease relevance of C5r1 Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats. A new small molecule C5a receptor antagonist inhibits the reverse- passive Arthus reaction and endotoxic shock in rats. A small molecule C5a receptor antagonist protects kidneys... / Synonyms: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a-R
Homo sapiens
Gene: ... Disease relevance of C5AR1 Expression of C3aR and C5aR could also be demonstrated on pDC in lesions of cutaneous lupus erythematosus and allergic contact dermatitis. Pertussis toxin or anti- C5aR/ CD88 antibody completely abolished the effect of recombinant human C5a on PAI- 1 production, suggesting a role of the C5a... / Synonyms: C5A; C5AR; C5R1
Mus musculus
Gene: ... Disease relevance of Prl2c5 The induction of bile acid hydroxylation and Mrp4 was independent of FXR but could not counteract liver toxicity sufficiently. High impact information on Prl2c5 The functional importance of MRP4 and BCRP in the urinary excretion of HCT and furosemide was investigated using...
Mus musculus
Gene: ... artificial chromosomes, that the gene Hc( encoding complement factor C5) underlies this locus. Genetic... locus. Such a tissue response is consistent with the known higher susceptibility of C5- deficient mice... in this important local defense mechanism. The anaphylatoxins complement component 3a and 5a( C3a and C5a... / Synonyms: C5; C5a; Complement C5
Mus musculus
Gene: ... Disease relevance of C5ar1 Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. AM lacking either C5... reconstitution with FcgammaRIIB- negative AM results in an enhanced pathology. These C5a- receptor- deficient... / Synonyms: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a-R
Mus musculus
Gene: ... Disease relevance of Gpr77 Accordingly, up- regulation of C5L2 may be of benefit in inflammatory states driven by C5a, including sepsis, asthma, cystic fibrosis, and chronic obstructive lung disease. With the use of serum IL- 6 as a marker for sepsis, infusion of anti- C5aR dramatically reduced serum IL- 6... / Synonyms: C5L2; C5a anaphylatoxin chemotactic receptor 2; C5l2
Homo sapiens
Gene: ... Disease relevance of GPR77 However, ligation of C5L2 by anaphylatoxin did potentiate... mechanism. Similarly, PMN from patients with progressive sepsis showed significantly reduced C5L2 expression...). CONCLUSIONS: The S323I variant may alter C5L2 function and might be one molecular basis contributing... / Synonyms: C5L2; C5a anaphylatoxin chemotactic receptor 2
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Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann