Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

C5ar2 - complement component 5a receptor 2

Mus musculus

Synonyms: C5L2, C5a anaphylatoxin chemotactic receptor 2, C5l2, Complement component 5a receptor 2, E030029A11Rik, ...

Gerard, N.P. et al., Gao, H. et al., Honczarenko, M. et al.

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Disease relevance of Gpr77

Accordingly, up-regulation of C5L2 may be of benefit in inflammatory states driven by C5a, including sepsis, asthma, cystic fibrosis, and chronic obstructive lung disease [1].
With the use of serum IL-6 as a marker for sepsis, infusion of anti-C5aR dramatically reduced serum IL-6 levels, while anti-C5L2 caused a nearly fourfold increase in IL-6 when compared with CLP controls treated with normal IgG [2].

High impact information on Gpr77

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2 [1].
C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear neutrophils [1].
C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12 [3].

References

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. Gerard, N.P., Lu, B., Liu, P., Craig, S., Fujiwara, Y., Okinaga, S., Gerard, C. J. Biol. Chem. (2005) [Pubmed]
Evidence for a functional role of the second C5a receptor C5L2. Gao, H., Neff, T.A., Guo, R.F., Speyer, C.L., Sarma, J.V., Tomlins, S., Man, Y., Riedemann, N.C., Hoesel, L.M., Younkin, E., Zetoune, F.S., Ward, P.A. FASEB J. (2005) [Pubmed]
C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12. Honczarenko, M., Lu, B., Nicholson-Weller, A., Gerard, N.P., Silberstein, L.E., Gerard, C. Leukemia (2005) [Pubmed]

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