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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Prl2c5  -  prolactin family 2, subfamily c, member 5

Mus musculus

Synonyms: MRP-4, Mrpplf4, PLF-4
 
 
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Disease relevance of Prl2c5

  • The induction of bile acid hydroxylation and Mrp4 was independent of FXR but could not counteract liver toxicity sufficiently [1].
 

High impact information on Prl2c5

  • The functional importance of MRP4 and BCRP in the urinary excretion of HCT and furosemide was investigated using gene knockout mice [2].
  • Unlike taurocholate uptake, S-methylglutathione had no effect on the ATP-dependent uptake of both compounds by MRP4 [2].
  • Our results suggest that Mrp4, together with other unknown transporters, accounts for the luminal efflux of HCT and furosemide from proximal tubular epithelial cells [2].
  • The gene expression level of Cyp3a11 was increased in the liver of Fxr(-/-) mice, whereas the protein expression levels of multidrug resistance-related protein 4 (Mrp4) were increased in kidneys of both genotypes during common bile duct ligation [3].
  • Mrp4 induction in the liver and kidney correlated with bile acid levels and was observed in UDCA-fed and CA-fed FXR(-/-) animals but not in CA-fed FXR(+/+) animals [1].

References

  1. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-{alpha}/beta in the adaptive response to bile acids. Zollner, G., Wagner, M., Moustafa, T., Fickert, P., Silbert, D., Gumhold, J., Fuchsbichler, A., Halilbasic, E., Denk, H., Marschall, H.U., Trauner, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  2. Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide. Hasegawa, M., Kusuhara, H., Adachi, M., Schuetz, J.D., Takeuchi, K., Sugiyama, Y. J. Am. Soc. Nephrol. (2007) [Pubmed]
  3. Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. Marschall, H.U., Wagner, M., Bodin, K., Zollner, G., Fickert, P., Gumhold, J., Silbert, D., Fuchsbichler, A., Sjövall, J., Trauner, M. J. Lipid Res. (2006) [Pubmed]
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