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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 266 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of MDM2 The cellular oncoprotein, Mdm2, binds to and downmodulates p53 function; its human homologue, MDM2, is amplified in certain human tumours, including sarcomas and gliomas. TP53... none showed amplification, but one had increased levels of MDM2 mRNA. Antisense therapy targeting MDM2... / Synonyms: E3 ubiquitin-protein ligase Mdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Mus musculus
Gene: ... Disease relevance of Mdm2 Mice lacking Mdm2 in the CNS developed hydranencephaly at embryonic day... affects irradiation- induced phosphorylation of Mdm2 and radioresistance of melanoma cells by perturbing the regulation of p53. Immunohistochemical analysis for Mdm2 and p53 proteins in methylcholanthrene- induced... / Synonyms: E3 ubiquitin-protein ligase Mdm2; Mdm-2; Oncoprotein Mdm2
Gallus gallus
Gene: ... High impact information on MDM2 Other p53- related genes including p21WAF1, p27Kip1, MDM- 2, and the p16INK4a alternate reading frame( ARF) sequence showed similar patterns of differential mRNA expression....
Felis catus
Gene: ... Disease relevance of MDM2 There was no significant difference in the expression of mdm2 m... lymphoma cell lines. High impact information on MDM2 Moreover, to explore whether mutational inactivation of the p53 gene or inactivation of the P53 protein caused by mdm2 gene overexpression, occurred...
Canis lupus familiaris
Gene: ... Disease relevance of MDM2 Analysis of p53 mutational events and MDM2 amplification in canine soft- tissue sarcomas. Mdm2 reactivity in reserve- like cells in adenomas showed wide variation, the immunoreactive cells ranging from 4 to 80%. In contrast to Mdm2 reactivity, each of 14 hyperplastic lesions...
Homo sapiens
Gene: ... Regulation of p53 and MDM2 activity by MTBP. A novel cellular protein( MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. Telomere- binding TRF2/ MTBP attaches telomeres to the nuclear... of MTBP Assignment of the MDM2 binding protein gene( MTBP) to human chromosome band 8q24 by in situ... / Synonyms: Mdm2-binding protein
Danio rerio
Gene: Synonyms: E3 ubiquitin-protein ligase Mdm2; p53-binding protein Mdm2
MeSH term: ... blood cells were isolated by Southern- blot analysis methods to determine MDM2 gene amplification... of Mdm2 proteins were determined using an immunohistochemical assay with monoclonal antibody 2A10, and MDM2 gene amplifications were studied by Southern blotting. Expression of BCRP messenger RNA( m...
Homo sapiens
Gene: ... in all esophageal cancers, whereas MDM2 T309G G/ G was associated with a 7- fold increased risk of death... that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. Furthermore, we... stabilized p53 by preventing MDM2- mediated p53 degradation in HRS cells. wt p53 stabilization and activation...

 

 
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