Gene Review:
Mdm2 - transformed mouse 3T3 cell double minute 2
Mus musculus
Synonyms:
1700007J15Rik, AA415488, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Mdm-2, ...
- Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Xiong, S., Van Pelt, C.S., Elizondo-Fraire, A.C., Liu, G., Lozano, G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance. Koma, Y.I., Ito, A., Watabe, K., Kimura, S.H., Kitamura, Y. Histol. Histopathol. (2004)
- Immunohistochemical analysis for Mdm2 and p53 proteins in methylcholanthrene-induced mouse rhabdomyosarcomas. Wu, H., Inoue, M. J. Vet. Med. Sci. (2006)
- Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Eischen, C.M., Weber, J.D., Roussel, M.F., Sherr, C.J., Cleveland, J.L. Genes Dev. (1999)
- Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. Uchida, C., Miwa, S., Kitagawa, K., Hattori, T., Isobe, T., Otani, S., Oda, T., Sugimura, H., Kamijo, T., Ookawa, K., Yasuda, H., Kitagawa, M. EMBO J. (2005)
- NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Wang, X., Trotman, L.C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C., Pandolfi, P.P., Jiang, X. Cell (2007)
- Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., McCormick, F. Cell (2000)
- Mdm2 promotes the rapid degradation of p53. Haupt, Y., Maya, R., Kazaz, A., Oren, M. Nature (1997)
- Regulation of p53 stability by Mdm2. Kubbutat, M.H., Jones, S.N., Vousden, K.H. Nature (1997)
- p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. Zhu, Y., Mao, X.O., Sun, Y., Xia, Z., Greenberg, D.A. J. Biol. Chem. (2002)
- Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. Aizu, W., Belinsky, G.S., Flynn, C., Noonan, E.J., Boes, C.C., Godman, C.A., Doshi, B., Nambiar, P.R., Rosenberg, D.W., Giardina, C. Biochem. Pharmacol. (2006)
- PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Bernardi, R., Scaglioni, P.P., Bergmann, S., Horn, H.F., Vousden, K.H., Pandolfi, P.P. Nat. Cell Biol. (2004)
- Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. Feng, J., Tamaskovic, R., Yang, Z., Brazil, D.P., Merlo, A., Hess, D., Hemmings, B.A. J. Biol. Chem. (2004)
- Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair. Alt, J.R., Bouska, A., Fernandez, M.R., Cerny, R.L., Xiao, H., Eischen, C.M. J. Biol. Chem. (2005)
- Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Steinman, H.A., Hoover, K.M., Keeler, M.L., Sands, A.T., Jones, S.N. Oncogene (2005)
- Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23. Bertwistle, D., Sugimoto, M., Sherr, C.J. Mol. Cell. Biol. (2004)
- Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. Wang, P., Gao, H., Ni, Y., Wang, B., Wu, Y., Ji, L., Qin, L., Ma, L., Pei, G. J. Biol. Chem. (2003)
- Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Foster, C.J., Lozano, G. Oncogene (2002)
- Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Jones, S.N., Roe, A.E., Donehower, L.A., Bradley, A. Nature (1995)
- Hypophosphorylation of Mdm2 augments p53 stability. Blattner, C., Hay, T., Meek, D.W., Lane, D.P. Mol. Cell. Biol. (2002)
- ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Maya, R., Balass, M., Kim, S.T., Shkedy, D., Leal, J.F., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., Kastan, M.B., Katzir, E., Oren, M. Genes Dev. (2001)
- A role for the polyproline domain of p53 in its regulation by Mdm2. Berger, M., Vogt Sionov, R., Levine, A.J., Haupt, Y. J. Biol. Chem. (2001)
- The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Jones, S.N., Sands, A.T., Hancock, A.R., Vogel, H., Donehower, L.A., Linke, S.P., Wahl, G.M., Bradley, A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Nucleolar Arf sequesters Mdm2 and activates p53. Weber, J.D., Taylor, L.J., Roussel, M.F., Sherr, C.J., Bar-Sagi, D. Nat. Cell Biol. (1999)
- Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Francoz, S., Froment, P., Bogaerts, S., De Clercq, S., Maetens, M., Doumont, G., Bellefroid, E., Marine, J.C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. Alt, J.R., Greiner, T.C., Cleveland, J.L., Eischen, C.M. EMBO J. (2003)
- Abrogation of G1 arrest after DNA damage is associated with constitutive overexpression of Mdm2, Cdk4, and Irf1 mRNAs in the BALB/c 3T3 A31 variant 1-1 clone. Nozaki, T., Masutani, M., Sugimura, T., Takato, T., Wakabayashi, K. Biochem. Biophys. Res. Commun. (1997)
- Reduced hepatic tumor incidence in cyclin G1-deficient mice. Jensen, M.R., Factor, V.M., Fantozzi, A., Helin, K., Huh, C.G., Thorgeirsson, S.S. Hepatology (2003)
- Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Grier, J.D., Xiong, S., Elizondo-Fraire, A.C., Parant, J.M., Lozano, G. Mol. Cell. Biol. (2006)
- Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. Lengner, C.J., Steinman, H.A., Gagnon, J., Smith, T.W., Henderson, J.E., Kream, B.E., Stein, G.S., Lian, J.B., Jones, S.N. J. Cell Biol. (2006)
- Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis. Daujat, S., Neel, H., Piette, J. Mech. Dev. (2001)
- The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis. Thisse, C., Neel, H., Thisse, B., Daujat, S., Piette, J. Differentiation (2000)
- TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents. Pääjärvi, G., Viluksela, M., Pohjanvirta, R., Stenius, U., Högberg, J. Carcinogenesis (2005)
- Regulation of p63 function by Mdm2 and MdmX. Kadakia, M., Slader, C., Berberich, S.J. DNA Cell Biol. (2001)