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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Your search matched a total of 108 documents. Results 1 - 10.

Homo sapiens
Gene: ... - sensitive cell lines were all MGMT- poor. The correlation of UV sensitivity with BCNU cytotoxicity suggests...Disease relevance of MGMT We have recently demonstrated that the MGMT gene is silenced by promoter methylation in many human tumors, including colorectal carcinomas. In addition, MGMT loss associated...
Mus musculus
Gene: ... Disease relevance of Mgmt Eight weeks after exposure to this dose of MNU, 40% of MNU- treated Mgmt... selective and impacts O6- bG- mediated enhancement of BCNU toxicity. These MGMT -/- mice were most sensitive...- old mice and survivals at the 30th day were determined, LD50s of MGMT -/- and MGMT +/+ mice were 20... / Synonyms: MGMT
Rattus norvegicus
Gene: ... , all variants expressed O6- methylguanine- DNA methyltransferase activity, while both kinds of cells... in 10 hepatoma cell lines, all derived from Reuber H35 hepatoma but differing in their status...Disease relevance of Mgmt Treatment of rat hepatoma cells( H4 cells) with various DNA- damaging... / Synonyms: MGMT
Canis lupus familiaris
Gene: ... Disease relevance of MGMT Using MGMT selection, long- term marking levels exceeding 50% can now be routinely attained with minimal toxicity. High impact information on MGMT Proline at position 140 and the surrounding amino acids of the human MGMT are highly conserved in the canine sequence. The human O( 6...
Gallus gallus
Gene: ... High impact information on MGMT Relationship between the depletion of O6- methylguanine- DNA methyltransferase by O6- methylguanine and the stimulation of DNA synthesis and growth of cultured chick hepatocytes. O6- Methylguanine- DNA methyltransferase( O6- MT) has been described as a DNA repair enzyme...
MeSH term: ... transcript unexpectedly affects both the expression of all transcripts in the cluster and methylation of two... questioned. We examined gliomas to determine whether methylation of the MGMT promoter is related... molecular profiles, and assessment of MGMT promoter methylation might contribute to improved patient...
MeSH term: ... therapeutic decision- making. High impact information on Glioma RESULTS: The MGMT promoter was methylated... with carmustine( 1, 3- bis( 2- chloroethyl )- 1- nitrosourea, or BCNU). Inactivation of the DNA- repair gene MGMT...


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