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Gene Review

Mgmt  -  O-6-methylguanine-DNA methyltransferase

Rattus norvegicus

Synonyms: 6-O-methylguanine-DNA methyltransferase, MGMT, Methylated-DNA--protein-cysteine methyltransferase, O-6-methylguanine-DNA-alkyltransferase
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Disease relevance of Mgmt


High impact information on Mgmt


Chemical compound and disease context of Mgmt


Biological context of Mgmt


Anatomical context of Mgmt


Associations of Mgmt with chemical compounds


Other interactions of Mgmt


Analytical, diagnostic and therapeutic context of Mgmt


  1. Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea resistance by gamma-irradiation or drug pretreatment in rat hepatoma cells. Habraken, Y., Laval, F. Cancer Res. (1991) [Pubmed]
  2. Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney. Pegg, A.E., Wiest, L. Cancer Res. (1983) [Pubmed]
  3. Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase. Kidney, J.K., Faustman, E.M. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  4. Adenoviral transfer of antisenses or ribozyme to O6-methylguanine-DNA methyltransferase mRNA in brain-tumor model resistant to chloroethyl-nitrosourea. Manome, Y., Yoshinaga, H., Watanabe, M., Ohno, T. Anticancer Res. (2002) [Pubmed]
  5. Development of a syngenic brain-tumor model resistant to chloroethyl-nitrosourea using a methylguanine DNA methyltransferase cDNA. Manome, Y., Watanabe, M., Futaki, K., Ishiguro, H., Iwagami, S., Noda, K., Dobashi, H., Ochiai, Y., Ohara, Y., Sanuki, K., Kunieda, T., Ohno, T. Anticancer Res. (1999) [Pubmed]
  6. Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Engelbergs, J., Thomale, J., Galhoff, A., Rajewsky, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea. Thomale, J., Huh, N.H., Nehls, P., Eberle, G., Rajewsky, M.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Differential expression of drug resistance genes and chemosensitivity in glial cell lineages correlate with differential response of oligodendrogliomas and astrocytomas to chemotherapy. Nutt, C.L., Noble, M., Chambers, A.F., Cairncross, J.G. Cancer Res. (2000) [Pubmed]
  9. Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats. Zeng, Z.Z., Higashi, S., Kitayama, W., Denda, A., Yan, Y., Matsuo, K., Konishi, Y., Hiai, H., Higashi, K. Cancer Res. (2000) [Pubmed]
  10. Enhancement of O6-methylguanine-DNA-methyltransferase activity induced by various treatments in mammalian cells. Lefebvre, P., Laval, F. Cancer Res. (1986) [Pubmed]
  11. The capacity of rat hepatoma cell lines for O6-methylguanine-DNA repair correlates with their status of differentiation. Hesse, S., Mezger, M., Wiebel, F.J. Carcinogenesis (1984) [Pubmed]
  12. The O6-methylguanine-DNA-methyltransferase activity of rat hepatoma cells is increased after a single exposure to alkylating agents. Frosina, G., Laval, F. Carcinogenesis (1987) [Pubmed]
  13. Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase. Psaroudi, M.C., Kyrtopoulos, S.A. Mutat. Res. (2000) [Pubmed]
  14. Cloning and expresion of cDNA for rat O6-methylguanine-DNA methyltransferase. Sakumi, K., Shiraishi, A., Hayakawa, H., Sekiguchi, M. Nucleic Acids Res. (1991) [Pubmed]
  15. cDNA cloning of the rat O6-methylguanine-DNA-methyltransferase. Rahden-Staron, I., Laval, F. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  16. Irradiation-induced expression of O6-methylguanine-DNA methyltransferase in mammalian cells. Chan, C.L., Wu, Z., Eastman, A., Bresnick, E. Cancer Res. (1992) [Pubmed]
  17. Dose response for DNA alkylation, [3H]thymidine uptake into DNA, and O6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine. Lindamood, C., Bedell, M.A., Billings, K.C., Dyroff, M.C., Swenberg, J.A. Cancer Res. (1984) [Pubmed]
  18. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Belinsky, S.A., White, C.M., Boucheron, J.A., Richardson, F.C., Swenberg, J.A., Anderson, M. Cancer Res. (1986) [Pubmed]
  19. Temporal cell-type-specific mRNA expression of O6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Takahashi, S., Hall, J., Montesano, R. Am. J. Pathol. (1996) [Pubmed]
  20. Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors. Kinjo, T., Suzui, M., Morioka, T., Inamine, M., Kaneshiro, T., Arakaki, J., Chiba, I., Sunagawa, N., Nishimaki, T., Yoshimi, N. Anticancer Res. (2006) [Pubmed]
  21. Modulation of O6-methylguanine-DNA methyltransferase in rat and hamster liver after treatment with dimethylnitrosamine. Hall, J., Brésil, H., Serres, M., Martel-Planche, G., Wild, C.P., Montesano, R. Cancer Res. (1990) [Pubmed]
  22. Alterations in the activities of DNA topoisomerase enzymes and O6-methylguanine-DNA-methyltransferase in septic rat liver. Srivenugopal, K.S., Schumer, W. Circ. Shock (1990) [Pubmed]
  23. Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation. Grombacher, T., Kaina, B. Biochim. Biophys. Acta (1995) [Pubmed]
  24. Repair of O6-methylguanine in rat pancreatic beta-cells after exposure to N-methyl-N-nitrosourea. Nelson, J.W., Ledoux, S.P., Wilson, G.L. Diabetes (1993) [Pubmed]
  25. Comparison of O6-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea. Inui, H., Watatani, M., Yasutomi, M., Nishisho, I. Carcinogenesis (1994) [Pubmed]
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