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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 57 documents. Results 1 - 10.

Homo sapiens
Gene: ... Disease relevance of OPRM1 OBJECTIVE: To replicate and extend the previously reported association between the opioid receptor mu subunit gene( OPRM1) and idiopathic absence epilepsy( IAE ), using a sample... and evaluated in membranes from pertussis toxin- treated cells. Smokers carrying the OPRM1 Asp40 variant( n= 82...
Danio rerio
Gene: ... High impact information on oprm1 Functional [( 35) S] guanosine 5 '-[ gamma- thio] triphosphate( GTPgammaS) stimulation experiments indicate that these two peptides fully activate the zebrafish opioid receptors, although the mean effective dose( EC( 50 )) values obtained for ZFOR2 and ZFOR3 receptors...
Bos taurus
Gene: ... High impact information on OPRM1 In cultured bovine adrenal medullary chromaffin cells( BAMCCs ), the activity of a calcium- dependent, voltage- sensitive, potassium( BK) channel is robustly potentiated by a mu- type opioid receptor, an effect consistent with the inhibitory role of opioids versus neural...
Mus musculus
Gene: ... Disease relevance of Oprm1 The mechanistic basis of these observations suggests that the anti... related information on Oprm1 Increasing evidence suggests that differences in Oprm1 gene sequences affect the amount of Oprm1 mRNA and sensitivity to opiates, and> 100 polymorphisms have been identified in the human...
Macaca mulatta
Gene: ... Disease relevance of OPRM1 6beta- Naltrexol was also less potent than naltrexone in antagonizing... impact information on OPRM1 The data support the use of nonhuman primates to investigate mu- opioid...) S] GTPgammaS binding, respectively. Biological context of OPRM1 A mu- opioid receptor single...
Rattus norvegicus
Gene: ... Disease relevance of Oprm1 Although pharmacological data indicate that M6G- induced hyperphagia... information on Oprm1 Significant increases in MOR internalization were observed following copulation... addiction) and do not appear to depend on the activation of MOR. High impact information on Oprm1...
MeSH term: ... the association between OPRM1 variants and substance dependence, when sex and age of subjects and alleles... ratio[ HR ], 0. 36; 95% confidence interval[ CI ], 0. 17- 0. 75). All mice were apo E (-/-) and CAM... population prediction, 491 consecutive newly diabetic children from all of Sweden were tested...
MeSH term: ... ), NOS2A( P< 0. 001 in Whites) and OPRM1( P= 0. 004 in Hispanics) gene haplotypes were associated... in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women... was at Hardy- Weinberg equilibrium in all three ethnic groups studied. The TBG polymorphism is inherited in X...
MeSH term: ... addiction. Genetic variants of OPRM1 have been implicated in predisposition to drug addiction, in particular...- like behaviors. Panic disorder, substance abuse, and thyroid disease were all unrelated to episode...
MeSH term: ... of the micro- opioid receptor gene( OPRM1 ), among 382 European Americans( EAs) affected with substance...

 

 
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