Gene Review:
Oprm1 - opioid receptor, mu 1
Mus musculus
Synonyms:
M-OR-1, MOP receptor, MOP-R, MOR-1, MOR-1O, ...
Uhl,
Sora,
Wang,
Ikeda,
Ide,
Han,
Hayashida,
Uhl,
Sora,
Chakrabarti,
Yang,
Law,
Loh,
Wu,
Hwang,
Yao,
Law,
Loh,
Wei,
Dahan,
Sarton,
Teppema,
Olievier,
Nieuwenhuijs,
Matthes,
Kieffer,
Im,
Smirnov,
Yuhi,
Raghavan,
Olsson,
Muscat,
Koopman,
Loh,
Hough,
Nalwalk,
Chen,
Schuller,
Zhu,
Zhang,
Menge,
Leurs,
Timmerman,
Pintar,
Garzón,
Rodríguez-Muñoz,
López-Fando,
Sánchez-Blázquez,
Chefer,
Kieffer,
Shippenberg,
Chefer,
Kieffer,
Shippenberg,
Hwang,
Kim,
Choi,
McKercher,
Loh,
Gavériaux-Ruff,
Matthes,
Peluso,
Kieffer,
- Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. Philippe, D., Dubuquoy, L., Groux, H., Brun, V., Chuoï-Mariot, M.T., Gaveriaux-Ruff, C., Colombel, J.F., Kieffer, B.L., Desreumaux, P. J. Clin. Invest. (2003)
- Transcriptional regulation of mouse mu opioid receptor gene by PU.1. Hwang, C.K., Kim, C.S., Choi, H.S., McKercher, S.R., Loh, H.H. J. Biol. Chem. (2004)
- A major species of mouse mu-opioid receptor mRNA and its promoter-dependent functional polyadenylation signal. Wu, Q., Hwang, C.K., Yao, S., Law, P.Y., Loh, H.H., Wei, L.N. Mol. Pharmacol. (2005)
- Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice. Dahan, A., Sarton, E., Teppema, L., Olievier, C., Nieuwenhuijs, D., Matthes, H.W., Kieffer, B.L. Anesthesiology (2001)
- Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors. Morin-Surun, M.P., Boudinot, E., Dubois, C., Matthes, H.W., Kieffer, B.L., Denavit-Saubié, M., Champagnat, J., Foutz, A.S. Eur. J. Neurosci. (2001)
- How individual sensitivity to opiates can be predicted by gene analyses. Ikeda, K., Ide, S., Han, W., Hayashida, M., Uhl, G.R., Sora, I. Trends Pharmacol. Sci. (2005)
- Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene. Gavériaux-Ruff, C., Matthes, H.W., Peluso, J., Kieffer, B.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Uhl, G.R., Sora, I., Wang, Z. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Wang, D., Raehal, K.M., Bilsky, E.J., Sadée, W. J. Neurochem. (2001)
- Enhanced morphine analgesia in mice lacking beta-arrestin 2. Bohn, L.M., Lefkowitz, R.J., Gainetdinov, R.R., Peppel, K., Caron, M.G., Lin, F.T. Science (1999)
- Mu-opioid receptor and CREB activation are required for nicotine reward. Walters, C.L., Cleck, J.N., Kuo, Y.C., Blendy, J.A. Neuron (2005)
- Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis. Macé, G., Miaczynska, M., Zerial, M., Nebreda, A.R. EMBO J. (2005)
- Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Pan, Y.X., Xu, J., Mahurter, L., Bolan, E., Xu, M., Pasternak, G.W. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Resistance to Diet-Induced Obesity in {micro}-Opioid Receptor-Deficient Mice: Evidence for a "Thrifty Gene". Tabarin, A., Chaves, Y.D., Carmona, M.d.e.l. .C., Catargi, B., Zorrilla, E.P., Roberts, A.J., Coscina, D.V., Rousset, S., Redonnet, A., Parker, G.C., Inoue, K., Ricquier, D., Pénicaud, L., Kieffer, B.L., Koob, G.F. Diabetes (2005)
- The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception. Sarton, E., Teppema, L.J., Olievier, C., Nieuwenhuijs, D., Matthes, H.W., Kieffer, B.L., Dahan, A. Anesth. Analg. (2001)
- Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice. Hough, L.B., Nalwalk, J.W., Chen, Y., Schuller, A., Zhu, Y., Zhang, J., Menge, W.M., Leurs, R., Timmerman, H., Pintar, J.E. Brain Res. (2000)
- Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Doyle, G.A., Rebecca Sheng, X., Lin, S.S., Press, D.M., Grice, D.E., Buono, R.J., Ferraro, T.N., Berrettini, W.H. Gene (2007)
- Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene. Min, B.H., Augustin, L.B., Felsheim, R.F., Fuchs, J.A., Loh, H.H. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Opioid receptor-induced GTPgamma35S binding during mouse development. Nitsche, J.F., Pintar, J.E. Dev. Biol. (2003)
- Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK(2) receptor deficient mice, but not in their wild-type littermates. Areda, T., Raud, S., Philips, M.A., Innos, J., Matsui, T., Kõks, S., Vasar, E., Karis, A., Asser, T. Behav. Brain Res. (2006)
- Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization. Garzón, J., Rodríguez-Muñoz, M., López-Fando, A., Sánchez-Blázquez, P. J. Biol. Chem. (2005)
- Mu Opioid Receptor Activation of ERK1/2 Is GRK3 and Arrestin Dependent in Striatal Neurons. Macey, T.A., Lowe, J.D., Chavkin, C. J. Biol. Chem. (2006)
- Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions. Law, P.Y., Erickson-Herbrandson, L.J., Zha, Q.Q., Solberg, J., Chu, J., Sarre, A., Loh, H.H. J. Biol. Chem. (2005)
- An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization. Groer, C.E., Tidgewell, K., Moyer, R.A., Harding, W.W., Rothman, R.B., Prisinzano, T.E., Bohn, L.M. Mol. Pharmacol. (2007)
- The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Chakrabarti, S., Yang, W., Law, P.Y., Loh, H.H. Mol. Pharmacol. (1997)
- The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. Wang, J., Charboneau, R., Balasubramanian, S., Barke, R.A., Loh, H.H., Roy, S. J. Leukoc. Biol. (2002)
- Transcriptional modulation of mouse mu-opioid receptor distal promoter activity by Sox18. Im, H.J., Smirnov, D., Yuhi, T., Raghavan, S., Olsson, J.E., Muscat, G.E., Koopman, P., Loh, H.H. Mol. Pharmacol. (2001)
- Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine. Chefer, V.I., Kieffer, B.L., Shippenberg, T.S. Neuroscience (2004)
- Morphine-induced changes in the activity of proopiomelanocortin and prodynorphin systems in zymosan-induced peritonitis in mice. Chadzinska, M., Starowicz, K., Scislowska-Czarnecka, A., Bilecki, W., Pierzchala-Koziec, K., Przewlocki, R., Przewlocka, B., Plytycz, B. Immunol. Lett. (2005)
- Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain. Pol, O., Murtra, P., Caracuel, L., Valverde, O., Puig, M.M., Maldonado, R. Neuropharmacology (2006)
- Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. Chefer, V.I., Kieffer, B.L., Shippenberg, T.S. Eur. J. Neurosci. (2003)