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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 24 documents. Results 1 - 10.

Homo sapiens
Gene: ... High impact information on UGT1A3 In human hepatic cells and human UGT1A transgenic mice, LXRalpha activators induce UGT1A3 mRNA levels and the formation of CDCA- 24glucuronide( 24G) and LCA- 24G. Finally, we observed that treatment of human hepatocytes with fibrates increases the expression and activity of UGT1A3...
Rattus norvegicus
Gene: Synonyms: UGT1A3
Homo sapiens
Gene: ... %), UGT1A3( 21 %), and UGT1A6( 36 %) was detected. Irinotecan is subjected to be shunted between CYP3A4...
Chemical compound: ... High impact information on Coumarin- 3- carboxylic acid Despite being a poor substrate with UGT1A3, coumarin- 3- carboxylic acid was not a substrate for any other UGT isoform tested in this study, suggesting that it could be a specific substrate for UGT1A3. The effect of lactic acid( lactate) on Fenton based hydroxyl...
Homo sapiens
Gene: ... M). Other interactions of UGT1A4 In contrast, all UGT isoforms, except for UGT1A3 and UGT1A4, catalyzed O... not fit the Michaelis- Menten plot, showing a K( m) of> 1 mM. UGT1A3 is 93% identical to UGT1A4 in primary... glucuronides formed from the UGT1A4 expressing microsomes. However, the UGT1A3 and UGT1A4 promoters exhibit low...
Homo sapiens
Gene: ... ( Vmax/ Km) with ibuprofen, ketoprofen, and others, compared to UGT1A3. Analytical, diagnostic...
Danio rerio
Gene: Synonyms: Ugt1a3
Chemical compound: ... of gemcabene was catalyzed by recombinant UGT1A3, recombinant UGT2B7, and recombinant UGT2B17, as well... IC( 50 )) when compared with recombinant UGT1A3- or recombinant UGT2B17- catalyzed gemcabene...
Chemical compound: ... is the most efficient enzyme conjugating benzamidoxime, whereas the conversion activities of UGT1A1 and UGT1A3...

 

 
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