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Chemical Compound Review

BP-11260     N'- hydroxybenzenecarboximidamide

Synonyms: ZINC12375727, AKOS004905617, HMS1401K03, IDI1_007034, AC1NS5VO, ...
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Disease relevance of N-Hydroxybenzamidine


High impact information on N-Hydroxybenzamidine


Associations of N-Hydroxybenzamidine with other chemical compounds


Gene context of N-Hydroxybenzamidine

  • UGT1A9 is the most efficient enzyme conjugating benzamidoxime, whereas the conversion activities of UGT1A1 and UGT1A3 were 60-fold lower [6].
  • For the N-reduction of benzamidoxime an oxygen-insensitive liver microsomal enzyme system that required cytochrome b5, NADH-cytochrome b5 reductase and a cytochrome P450 isoenzyme of the subfamily 2D has been described [7].
  • Furthermore, the involvement of human UDP-glucuronosyltransferases (UGTs) was examined by incubating benzamidoxime in the presence of eight human hepatic recombinant UGT enzymes [6].

Analytical, diagnostic and therapeutic context of N-Hydroxybenzamidine


  1. Genotoxic activities of benzamidine and its N-hydroxylated metabolite benzamidoxime in Salmonella typhimurium and mammalian cells. Clement, B., Schmezer, P., Weber, H., Schlehofer, J.R., Schmitt, S., Pool, B.L. J. Cancer Res. Clin. Oncol. (1988) [Pubmed]
  2. Identification of the Missing Component in the Mitochondrial Benzamidoxime Prodrug-converting System as a Novel Molybdenum Enzyme. Havemeyer, A., Bittner, F., Wollers, S., Mendel, R., Kunze, T., Clement, B. J. Biol. Chem. (2006) [Pubmed]
  3. Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing. Clement, B., Christiansen, K., Girreser, U. Chem. Res. Toxicol. (2001) [Pubmed]
  4. Reduction of amphetamine hydroxylamine and other aliphatic hydroxylamines by benzamidoxime reductase and human liver microsomes. Clement, B., Behrens, D., Möller, W., Cashman, J.R. Chem. Res. Toxicol. (2000) [Pubmed]
  5. Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid). Clement, B., Mau, S., Deters, S., Havemeyer, A. Drug Metab. Dispos. (2005) [Pubmed]
  6. Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases. Fröhlich, A.K., Girreser, U., Clement, B. Xenobiotica (2005) [Pubmed]
  7. Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Clement, B., Behrens, D., Amschler, J., Matschke, K., Wolf, S., Havemeyer, A. Life Sci. (2005) [Pubmed]
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