Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem11094 2-oxochromene-3-carboxylic acid

Synonyms: CHEMBL83294, C85603_ALDRICH, AG-A-45102, CBDivE_014214, ACMC-20aldi, ...

Makrigiorgos, G.M. et al., Ali, M.A. et al., Sakaguchi, K. et al., Kennedy, S.H. et al.

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High impact information on Coumarin-3-carboxylic acid

Despite being a poor substrate with UGT1A3, coumarin-3-carboxylic acid was not a substrate for any other UGT isoform tested in this study, suggesting that it could be a specific substrate for UGT1A3 [1].
The effect of lactic acid (lactate) on Fenton based hydroxyl radical (*OH) production was studied by spin trapping, ESR, and fluorescence methods using DMPO and coumarin-3-carboxylic acid (3-CCA) as the *OH traps respectively [2].
BP is shown to be capable of generating free radicals, determined by the kinetics of hydroxylation as measured by fluorescence of coumarin-3-carboxylic acid [3].
Polylysine and histone H1 were labelled with SECCA, the succinimidyl ester of coumarin-3-carboxylic acid, which generates the fluorescent derivative 7-OH-SECCA following its interaction with radiation-induced OH in aqueous solution [4].

References

Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms. Sakaguchi, K., Green, M., Stock, N., Reger, T.S., Zunic, J., King, C. Arch. Biochem. Biophys. (2004) [Pubmed]
The lactate-dependent enhancement of hydroxyl radical generation by the Fenton reaction. Ali, M.A., Yasui, F., Matsugo, S., Konishi, T. Free Radic. Res. (2000) [Pubmed]
Benzoyl peroxide acts as a promoter of radiation induced malignant transformation in vitro. Kennedy, S.H., Manevich, Y., Biaglow, J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Accessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study. Makrigiorgos, G.M., Bump, E., Huang, C., Baranowska-Kortylewicz, J., Kassis, A.I. Int. J. Radiat. Biol. (1994) [Pubmed]

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