Gene Review:
UGT1A3 - UDP glucuronosyltransferase 1 family,...
Homo sapiens
Synonyms:
GNT1, UDP-glucuronosyltransferase 1-3, UDP-glucuronosyltransferase 1-C, UDP-glucuronosyltransferase 1A3, UDPGT, ...
Ghosal,
Sawada,
Saito,
Patrick,
Zbaida,
Breyer-Pfaff,
Alvarez,
Andersson,
Ando,
Yuan,
Kaji,
Tephly,
Jinno,
Chowdhury,
Hapangama,
Sabolovic,
Su,
Mankowitz,
Hagigi,
Magdalou,
Ozawa,
Alton,
Mey,
Aberg,
Li,
Baranczewski,
Little,
Green,
Radominska-Pandya,
Hanioka,
Kallin,
Kume,
Heydel,
Humbert,
Postlind,
- The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J.A., Bélanger, J., Kaeding, J., Staels, B., Caron, P., Tukey, R.H., Barbier, O. Hepatology (2006)
- Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Trottier, J., Verreault, M., Grepper, S., Mont??, D., B??langer, J., Kaeding, J., Caron, P., Inaba, T.T., Barbier, O. Hepatology (2006)
- Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Ehmer, U., Vogel, A., Schütte, J.K., Krone, B., Manns, M.P., Strassburg, C.P. Hepatology (2004)
- Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. Basu, N.K., Kubota, S., Meselhy, M.R., Ciotti, M., Chowdhury, B., Hartori, M., Owens, I.S. J. Biol. Chem. (2004)
- Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Green, M.D., King, C.D., Mojarrabi, B., Mackenzie, P.I., Tephly, T.R. Drug Metab. Dispos. (1998)
- Development of an assay using 4-trifluoromethylumbelliferyl as a marker substrate for assessment of drug-drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Baranczewski, P., Kallin, A., Andersson, A., Hagigi, S., Aberg, M., Postlind, H., Mankowitz, L. Assay and drug development technologies. (2004)
- Genetic variants of human UGT1A3: functional characterization and frequency distribution in a Chinese Han population. Chen, Y., Chen, S., Li, X., Wang, X., Zeng, S. Drug Metab. Dispos. (2006)
- Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Cheng, Z., Rios, G.R., King, C.D., Coffman, B.L., Green, M.D., Mojarrabi, B., Mackenzie, P.I., Tephly, T.R. Toxicol. Sci. (1998)
- Isolation of the UDP-Glucuronosyltransferase 1A3 and 1A4 Proximal Promoters and Characterization of Their Dependence on the Transcription Factor Hepatocyte Nuclear Factor 1{alpha}. Gardner-Stephen, D.A., Mackenzie, P.I. Drug Metab. Dispos. (2007)
- Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue. Chouinard, S., Tessier, M., Vernouillet, G., Gauthier, S., Labrie, F., Barbier, O., Bélanger, A. Mol. Pharmacol. (2006)
- cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3. Mojarrabi, B., Butler, R., Mackenzie, P.I. Biochem. Biophys. Res. Commun. (1996)
- Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin. Hanioka, N., Ozawa, S., Jinno, H., Ando, M., Saito, Y., Sawada, J. Xenobiotica (2001)
- Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s). Kaji, H., Kume, T. Drug Metab. Dispos. (2005)
- Comparative N-glucuronidation kinetics of ketotifen and amitriptyline by expressed human UDP-glucuronosyltransferases and liver microsomes. Breyer-Pfaff, U., Mey, U., Green, M.D., Tephly, T.R. Drug Metab. Dispos. (2000)
- N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. Ghosheh, O., Hawes, E.M. Drug Metab. Dispos. (2002)
- Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities. Vashishtha, S.C., Hawes, E.M., McKay, G., McCann, D.J. Drug Metab. Dispos. (2001)
- N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases. Kuehl, G.E., Murphy, S.E. Drug Metab. Dispos. (2003)
- Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms. Sakaguchi, K., Green, M., Stock, N., Reger, T.S., Zunic, J., King, C. Arch. Biochem. Biophys. (2004)
- A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3. Caillier, B., Lépine, J., Tojcic, J., Ménard, V., Perusse, L., Bélanger, A., Barbier, O., Guillemette, C. Pharmacogenet. Genomics (2007)
- Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids. Erichsen, T.J., Aehlen, A., Ehmer, U., Kalthoff, S., Manns, M.P., Strassburg, C.P. J. Hepatol. (2010)
- Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract. Sabolovic, N., Heydel, J.M., Li, X., Little, J.M., Humbert, A.C., Radominska-Pandya, A., Magdalou, J. Biochim. Biophys. Acta (2004)
- Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Ghosal, A., Yuan, Y., Hapangama, N., Su, A.D., Alvarez, N., Chowdhury, S.K., Alton, K.B., Patrick, J.E., Zbaida, S. Biopharmaceutics & drug disposition. (2004)
- Heterologous expression of active human uridine diphosphate glucuronosyltransferase 1A3 in Chinese hamster lung cells. Chen, Y.K., Li, X., Chen, S.Q., Zeng, S. World J. Gastroenterol. (2005)