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Chemical Compound Review

AG-L-18278     sulfanylidenemethanone

Synonyms: CHEBI:16573, HSDB 6127, LS-1276, AC1Q6BOR, CTK4I9336, ...
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High impact information on thioxomethanone

  • Carbon dioxide (CO2) was the major volatile metabolite of CS2 in hepatocytes, and carbonyl sulfide (COS) was the major volatile metabolite in microsomal incubations [1].
  • When [18O]H2O was included in incubations of microsomes and CS2, a substantial portion of the resulting COS was [18O] enriched, indicating that the oxygen atom was derived from water [1].
  • Addition of cytosol to microsomal incubations shifted the predominant volatile metabolite from COS to CO2 but did not change total volatile metabolite formation [1].


  1. Oxidative metabolism of carbon disulfide by isolated rat hepatocytes and microsomes. Chengelis, C.P., Neal, R.A. Biochem. Pharmacol. (1987) [Pubmed]
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