Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-H-23238 1,3-bis(4-hydroxycyclohexyl)- 1-nitroso-urea

Synonyms: NSC-305715, AC1L2OTP, CTK5E7757, NSC305715, LS-159063, ...

Tew, K.D. et al., Bodell, W.J. et al.

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High impact information on YS2713000

Treatment of 9L, 9L-2, 9L-7, and 9L-8 cell lines with 1,3-bis(trans-4-hydroxycyclohexyl)-1-nitrosourea produced approximately the same level of cell kill [1].
These morphological and cytogenetic changes correlate with cytotoxic responses of these cell lines to N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea and would be consistent with drug-induced inhibition of glutathione reductase [2].

References

Investigation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas. Bodell, W.J., Gerosa, M., Aida, T., Berger, M.S., Rosenblum, M.L. Cancer Res. (1985) [Pubmed]
Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas. Tew, K.D., Kyle, G., Johnson, A., Wang, A.L. Cancer Res. (1985) [Pubmed]

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