Gene Review:
Gsr - glutathione reductase
Rattus norvegicus
Synonyms:
GR, GRase, Glutathione reductase
- Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Moreno, J.M., Rodríguez Gómez, I., Wangensteen, R., Osuna, A., Bueno, P., Vargas, F. Am. J. Physiol. Endocrinol. Metab. (2005)
- Lipid peroxidation and glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and glucose-6-phosphate dehydrogenase activities in FeCl3-induced epileptogenic foci in the rat brain. Singh, R., Pathak, D.N. Epilepsia (1990)
- Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition. Sainz, J., Wangensteen, R., Rodríguez Gómez, I., Moreno, J.M., Chamorro, V., Osuna, A., Bueno, P., Vargas, F. Am. J. Hypertens. (2005)
- Effects of Vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Senthil kumar, J., Banudevi, S., Sharmila, M., Murugesan, P., Srinivasan, N., Balasubramanian, K., Aruldhas, M.M., Arunakaran, J. Reprod. Toxicol. (2004)
- Protective effects of zinc on oxidative stress enzymes in liver of protein deficient rats. Sidhu, P., Garg, M.L., Dhawan, D.K. Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral. (2004)
- Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity. Powell, S.R., Puglia, C.D. J. Pharmacol. Exp. Ther. (1987)
- Effects of riboflavin deficiency on metabolism of nitrosamines by rat liver microsomes. Wang, T., Miller, K.W., Tu, Y.Y., Yang, C.S. J. Natl. Cancer Inst. (1985)
- Modulation of azaserine-induced pancreatic foci by phenolic antioxidants in rats. Roebuck, B.D., MacMillan, D.L., Bush, D.M., Kensler, T.W. J. Natl. Cancer Inst. (1984)
- Observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting. Balsam, A., Ingbar, S.H. J. Clin. Invest. (1979)
- Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Sandalova, T., Zhong, L., Lindqvist, Y., Holmgren, A., Schneider, G. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Chemopreventive potential of luteolin during colon carcinogenesis induced by 1,2-dimethylhydrazine. Manju, V., Nalini, N. Ital. J. Biochem. (2005)
- Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol-induced liver injury. Senthilkumar, R., Sengottuvelan, M., Nalini, N. Cell Biochem. Funct. (2004)
- Neuroprotective effect of N-acetyl cysteine on hypoxia-induced oxidative stress in primary hippocampal culture. Jayalakshmi, K., Sairam, M., Singh, S.B., Sharma, S.K., Ilavazhagan, G., Banerjee, P.K. Brain Res. (2005)
- Differential inhibition of rat hepatic glutathione S-transferase isoenzymes in the course of fascioliasis. Galtier, P., Vandenberghe, Y., Coecke, S., Eeckhoutte, C., Larrieu, G., Vercruysse, A. Mol. Biochem. Parasitol. (1991)
- Changes in the glutathione redox system during ischemia and reperfusion in rat liver. Kobayashi, H., Nonami, T., Kurokawa, T., Kitahara, S., Harada, A., Nakao, A., Sugiyama, S., Ozawa, T., Takagi, H. Scand. J. Gastroenterol. (1992)
- Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Maldonado, P.D., Barrera, D., Rivero, I., Mata, R., Medina-Campos, O.N., Hernández-Pando, R., Pedraza-Chaverrí, J. Free Radic. Biol. Med. (2003)
- Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. Pablos, M.I., Reiter, R.J., Chuang, J.I., Ortiz, G.G., Guerrero, J.M., Sewerynek, E., Agapito, M.T., Melchiorri, D., Lawrence, R., Deneke, S.M. J. Appl. Physiol. (1997)
- The capacity of glutathione reductase in cell protection from the toxic effect of heated oils. Saka, S., Aouacheri, W., Abdennour, C. Biochimie (2002)
- Effects of ethanol on antioxidant capacity in isolated rat hepatocytes. Yang, S.S., Huang, C.C., Chen, J.R., Chiu, C.L., Shieh, M.J., Lin, S.J., Yang, S.C. World J. Gastroenterol. (2005)
- Effect of disulfiram administration on rat brain glutathione metabolism. Nagendra, S.N., Shetty, K.T., Rao, K.M., Rao, B.S. Alcohol (1994)
- Effects of chlorpromazine on the activities of antioxidant enzymes and lipid peroxidation in the various regions of aging rat brain. Roy, D., Pathak, D.N., Singh, R. J. Neurochem. (1984)
- Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age. Rodríguez-Martínez, M.A., Alonso, M.J., Redondo, J., Salaíces, M., Marín, J. Br. J. Pharmacol. (1998)
- Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes. Wu, C.C., Lii, C.K., Tsai, S.J., Sheen, L.Y. J. Nutr. (2004)
- Distribution of glutathione peroxidases and glutathione reductase in rat brain mitochondria. Panfili, E., Sandri, G., Ernster, L. FEBS Lett. (1991)
- Antioxidant systems in rat epididymal spermatozoa. Tramer, F., Rocco, F., Micali, F., Sandri, G., Panfili, E. Biol. Reprod. (1998)
- Oxygen toxicity: comparison of lung biochemical responses in neonatal and adult rats. Yam, J., Frank, L., Roberts, R.J. Pediatr. Res. (1978)
- Sex hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble rats. Tam, N.N., Ghatak, S., Ho, S.M. Prostate (2003)
- HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Price, T.O., Ercal, N., Nakaoke, R., Banks, W.A. Brain Res. (2005)
- Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. Rybak, L.P., Husain, K., Whitworth, C., Somani, S.M. Toxicol. Sci. (1999)
- An investigation into the effect of sulfonylurea glyburide on glutathione peroxidase activity in streptozotocin-induced diabetic rat muscle tissue. Kiliç, N., Malhatun, E., Elmali, E., Altan, N. Gen. Pharmacol. (1998)
- Regional distribution of glutathione reductase in the adult rat brain. Brannan, T.S., Maker, H.S., Raes, I., Weiss, C. Brain Res. (1980)
- Antioxidant defense mechanisms in cultured pleural mesothelial cells. Kinnula, V.L., Everitt, J.I., Mangum, J.B., Chang, L.Y., Crapo, J.D. Am. J. Respir. Cell Mol. Biol. (1992)
- Involvement of reactive oxygen species and stress-activated MAPKs in satratoxin H-induced apoptosis. Nusuetrong, P., Yoshida, M., Tanitsu, M.A., Kikuchi, H., Mizugaki, M., Shimazu, K., Pengsuparp, T., Meksuriyen, D., Oshima, Y., Nakahata, N. Eur. J. Pharmacol. (2005)
- Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system. Romero-Ramos, M., Venero, J.L., Garcia-Rodriguez, S., Ayala, A., Machado, A., Cano, J. Free Radic. Res. (2003)
- The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Lock, E.A., Schnellmann, R.G. Toxicol. Appl. Pharmacol. (1990)
- Acteoside and its aglycones protect primary cultures of rat cortical cells from glutamate-induced excitotoxicity. Koo, K.A., Kim, S.H., Oh, T.H., Kim, Y.C. Life Sci. (2006)
- Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes. Barrera, D., Maldonado, P.D., Medina-Campos, O.N., Hernández-Pando, R., Ibarra-Rubio, M.E., Pedraza-Chaverrí, J. Life Sci. (2003)
- Age-related metabolic effects of acetaldehyde on rats with reference to detoxification enzymes and sulfhydryl groups. Devi, G.U., Indira, K., Babu, G.R., Chetty, C.S. Biomed. Environ. Sci. (1996)
- Acinar distribution of glutathione-dependent detoxifying enzymes. Low glutathione peroxidase activity in perivenous hepatocytes. Kera, Y., Sippel, H.W., Penttilä, K.E., Lindros, K.O. Biochem. Pharmacol. (1987)
- Influence of rat brain superoxide dismutase inhibition by diethyldithiocarbamate upon the rate of development of central nervous system oxygen toxicity. Puglia, C.D., Loeb, G.A. Toxicol. Appl. Pharmacol. (1984)
- Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. Sen, C.K., Marin, E., Kretzschmar, M., Hänninen, O. J. Appl. Physiol. (1992)
- Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Fujii, T., Endo, T., Fujii, J., Taniguchi, N. Free Radic. Res. (2002)
- Glutathione dependent detoxication in adult rat hepatocytes under various culture conditions. Mertens, K., Rogiers, V., Vercruysse, A. Arch. Toxicol. (1993)
- Effects of progesterone and estradiol benzoate on glutathione dependent antioxidant enzyme activities in the brain of female rats. Pajović, S.B., Saicić, Z.S., Spasić, M.B., Petrović, V.M., Martinović, J.V. Gen. Physiol. Biophys. (1999)