Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L1AIZ [5-[6-amino-1-[3,4-dihydroxy- 5...

Synonyms:

Elkaim, R. et al., Wielckens, K. et al., Sivaraman, J. et al., Apolinario, E. et al.

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Disease relevance of phosphoribosyl-AMP

The his7+ gene is able to complement a mutation of the Escherichia coli hisI gene, suggesting that his7+ encodes a phosphoribosyl-AMP cyclohydrase [1].

High impact information on phosphoribosyl-AMP

Hydrolysis of phosphoribosyl-AMP, the third step in the histidine biosynthetic pathway, is carried out by PR-AMP cyclohydrolase, the product of the hisI gene [2].
The in vitro synthesized acid insoluble material is rendered partly soluble by treatment by a proteolytic enzyme or by snake venom phosphodiesterase resulting in phosphoribosyl-AMP formation: the pancreatic RNase does not solubilize this material [3].

Analytical, diagnostic and therapeutic context of phosphoribosyl-AMP

Determination of poly(ADP-ribose) levels was performed by a new procedure involving covalent chromatography of released polymer, degradation to phosphoribosyl AMP and quantification of this specific derivative by a radioimmunoassay [4].

References

Cloning and manipulation of the Schizosaccharomyces pombe his7+ gene as a new selectable marker for molecular genetic studies. Apolinario, E., Nocero, M., Jin, M., Hoffman, C.S. Curr. Genet. (1993) [Pubmed]
Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI. Sivaraman, J., Myers, R.S., Boju, L., Sulea, T., Cygler, M., Jo Davisson, V., Schrag, J.D. Biochemistry (2005) [Pubmed]
Adenosine diphosphate ribosyltransferase and protein acceptors associated with cytoplasmic free messenger ribonucleoprotein particles. Elkaim, R., Thomassin, H., Niedergang, C., Egly, J.M., Kempf, J., Mandel, P. Biochimie (1983) [Pubmed]
Protein-bound polymeric and monomeric ADP-ribose residues in hepatic tissues. Comparative analyses using a new procedure for the quantification of poly(ADP-ribose). Wielckens, K., Bredehorst, R., Adamietz, P., Hilz, H. Eur. J. Biochem. (1981) [Pubmed]

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