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Chemical Compound Review

AC1L1AIZ     [5-[6-amino-1-[3,4-dihydroxy- 5...

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Disease relevance of phosphoribosyl-AMP


High impact information on phosphoribosyl-AMP

  • Hydrolysis of phosphoribosyl-AMP, the third step in the histidine biosynthetic pathway, is carried out by PR-AMP cyclohydrolase, the product of the hisI gene [2].
  • The in vitro synthesized acid insoluble material is rendered partly soluble by treatment by a proteolytic enzyme or by snake venom phosphodiesterase resulting in phosphoribosyl-AMP formation: the pancreatic RNase does not solubilize this material [3].

Analytical, diagnostic and therapeutic context of phosphoribosyl-AMP

  • Determination of poly(ADP-ribose) levels was performed by a new procedure involving covalent chromatography of released polymer, degradation to phosphoribosyl AMP and quantification of this specific derivative by a radioimmunoassay [4].


  1. Cloning and manipulation of the Schizosaccharomyces pombe his7+ gene as a new selectable marker for molecular genetic studies. Apolinario, E., Nocero, M., Jin, M., Hoffman, C.S. Curr. Genet. (1993) [Pubmed]
  2. Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI. Sivaraman, J., Myers, R.S., Boju, L., Sulea, T., Cygler, M., Jo Davisson, V., Schrag, J.D. Biochemistry (2005) [Pubmed]
  3. Adenosine diphosphate ribosyltransferase and protein acceptors associated with cytoplasmic free messenger ribonucleoprotein particles. Elkaim, R., Thomassin, H., Niedergang, C., Egly, J.M., Kempf, J., Mandel, P. Biochimie (1983) [Pubmed]
  4. Protein-bound polymeric and monomeric ADP-ribose residues in hepatic tissues. Comparative analyses using a new procedure for the quantification of poly(ADP-ribose). Wielckens, K., Bredehorst, R., Adamietz, P., Hilz, H. Eur. J. Biochem. (1981) [Pubmed]
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