Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Promizol 5-(4-aminophenyl)sulfonyl- 1,3-thiazol-2-amine

Synonyms: Promizole, Thiazosulfon, Tiazosolfone, Tiazosulfona, Thiazosulfone, ...

Magon, A.M. et al., Magon, A. et al.

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Disease relevance of Thiazosulfon

Our results indicate that G6PD-deficient, genetically slow acetylators, having high microsomal activity, would be most susceptible to Promizole- or DDS-induced hemolysis, compared to other metabolic phenotypes [1].

High impact information on Thiazosulfon

In addition, the bimodality in hemolytic response to Promizole probably corresponds to the bimodal distribution of acetylator phenotype in the population [1].
3) Acetylation seems to markedly reduce the hemolytic potential of two drugs studied: promizole and DDS [2].
The genetic polymorphism in acetylation may explain the bimodal response to promizole [2].

Anatomical context of Thiazosulfon

We found that in the presence of induced (high hydroxylase activity) microsomes, thiazolsulfone (Promizole) or DDS in unacetylated form caused the highest level of GSH depletion in G6PD-deficient red cells [1].

References

Interactions of glucose-6-phosphate dehydrogenase deficiency with drug acetylation and hydroxylation reactions. Magon, A.M., Leipzig, R.M., Zannoni, V.G., Brewer, G.J. J. Lab. Clin. Med. (1981) [Pubmed]
Pharmacogenetic interactions in G6PD deficiency and development of an in vitro test to predict a drug's hemolytic potential. Magon, A., Leipzig, R.M., Bloom, K., Brewer, G.J. Prog. Clin. Biol. Res. (1981) [Pubmed]

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