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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hemolysis


Psychiatry related information on Hemolysis


High impact information on Hemolysis


Chemical compound and disease context of Hemolysis


Biological context of Hemolysis


Anatomical context of Hemolysis

  • Addition of saline-adenine-glucose solutions (40 to 100 ml per blood unit) to buffy-coat-poor red-cell concentrates allowed storage for as long as 35 days with 24-hour erythrocyte post-transfusion survival of 83 +/- 6.8 per cent (+/0 S.D.). Potassium leakage was lower, and in vitro hemolysis somewhat higher than that of whole blood [22].
  • To ascertain the clinical significance of dimethyl sulfoxide-induced pigmenturia, we evaluated renal function and indicators of systemic hemolysis in stable quadriplegic patients receiving the drug intravenously (IV) for spinal cord injury [23].
  • At low temperatures (on ice), PFP binds to erythrocyte membranes without producing hemolysis [24].
  • The proliferation of erythroblasts after MuEV infection in animals not receiving poly I-poly C appeared to be an erythropoietin-dependent compensatory response to hemolysis [25].
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder characterized by complement-mediated hemolysis due to deficiencies of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in subpopulations of blood cells [26].

Gene context of Hemolysis

  • These proteins include the complement inhibitors CD55 and CD59, and this explains the hypersensitivity to complement of red cells in PNH patients, manifested by intravascular hemolysis [27].
  • Specifically, we found no evidence that G6PD enhanced the severity of hemolysis or increased the incidence of acute anemic episodes or sepsis in HbSS [28].
  • Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice [29].
  • Both subunits of clusterin interact with C9 and are similarly potent in inhibiting C5b-9-mediated hemolysis and Zn+(+)-induced C9 polymerization [30].
  • The interference of hemolysis by BII-1 could not be explained by inhibition of activation of C4B or inhibition of C3 or C5 convertase activity [31].

Analytical, diagnostic and therapeutic context of Hemolysis


  1. Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. Rodgers, G.P., Dover, G.J., Uyesaka, N., Noguchi, C.T., Schechter, A.N., Nienhuis, A.W. N. Engl. J. Med. (1993) [Pubmed]
  2. Natural history of paroxysmal nocturnal hemoglobinuria. Hillmen, P., Lewis, S.M., Bessler, M., Luzzatto, L., Dacie, J.V. N. Engl. J. Med. (1995) [Pubmed]
  3. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. Booth, C.M., Matukas, L.M., Tomlinson, G.A., Rachlis, A.R., Rose, D.B., Dwosh, H.A., Walmsley, S.L., Mazzulli, T., Avendano, M., Derkach, P., Ephtimios, I.E., Kitai, I., Mederski, B.D., Shadowitz, S.B., Gold, W.L., Hawryluck, L.A., Rea, E., Chenkin, J.S., Cescon, D.W., Poutanen, S.M., Detsky, A.S. JAMA (2003) [Pubmed]
  4. Hemolytic anemias and erythrocyte enzymopathies. Valentine, W.N., Tanaka, K.R., Paglia, D.E. Ann. Intern. Med. (1985) [Pubmed]
  5. Hematologic aspects of systemic lupus erythematosus. Current concepts. Budman, D.R., Steinberg, A.D. Ann. Intern. Med. (1977) [Pubmed]
  6. Effects of Ca2+ on erythrocyte membrane skeleton-bound phosphofructokinase, ATP levels, and hemolysis. Assouline-Cohen, M., Beitner, R. Mol. Genet. Metab. (1999) [Pubmed]
  7. No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population. Cetin, M., Pinarbasi, E., Percin, F.E., Akgün, E., Percin, S., Pinarbasi, H., Gurlek, F., Cetin, A. J. Obstet. Gynaecol. Res. (2005) [Pubmed]
  8. Metformin-induced hemolysis with jaundice. Lin, K.D., Lin, J.D., Juang, J.H. N. Engl. J. Med. (1998) [Pubmed]
  9. GM-CSF and accelerated hemolysis. Nathan, F.E., Besa, E.C. N. Engl. J. Med. (1992) [Pubmed]
  10. Hemolysis from exposure to naphthalene mothballs. Todisco, V., Lamour, J., Finberg, L. N. Engl. J. Med. (1991) [Pubmed]
  11. Impaired reticuloendothelial function in patients treated with methyldopa. Kelton, J.G. N. Engl. J. Med. (1985) [Pubmed]
  12. Treatment of sickle cell anemia with hydroxyurea and erythropoietin. Goldberg, M.A., Brugnara, C., Dover, G.J., Schapira, L., Charache, S., Bunn, H.F. N. Engl. J. Med. (1990) [Pubmed]
  13. Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. Corash, L., Spielberg, S., Bartsocas, C., Boxer, L., Steinherz, R., Sheetz, M., Egan, M., Schlessleman, J., Schulman, J.D. N. Engl. J. Med. (1980) [Pubmed]
  14. Salicylate-induced injury of pyruvate-kinase-deficient erythrocytes. Glader, B.E. N. Engl. J. Med. (1976) [Pubmed]
  15. Formaldehyde-induced hemolysis during chronic hemodialysis. Orringer, E.P., Mattern, W.D. N. Engl. J. Med. (1976) [Pubmed]
  16. Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. Rodgers, G.P., Dover, G.J., Noguchi, C.T., Schechter, A.N., Nienhuis, A.W. N. Engl. J. Med. (1990) [Pubmed]
  17. Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis. Alper, C.A., Colten, H.R., Gear, J.S., Rabson, A.R., Rosen, F.S. J. Clin. Invest. (1976) [Pubmed]
  18. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease. Brink, M.A., Slors, J.F., Keulemans, Y.C., Mok, K.S., De Waart, D.R., Carey, M.C., Groen, A.K., Tytgat, G.N. Gastroenterology (1999) [Pubmed]
  19. Toward functional genomics in bacteria: analysis of gene expression in Escherichia coli from a bacterial artificial chromosome library of Bacillus cereus. Rondon, M.R., Raffel, S.J., Goodman, R.M., Handelsman, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. Genetic differences in hemoglobin influence on erythrocyte oxidative stress hemolysis. Kruckeberg, W.C., Doorenbos, D.I., Brown, P.O. Blood (1987) [Pubmed]
  21. Effect of heparin on complement activation and lysis of paroxysmal nocturnal hemoglobinuria (PNH) red cells. Logue, G.L. Blood (1977) [Pubmed]
  22. Clinical usefulness of red cells preserved in protein-poor mediums. Högman, C.F., Hedlund, K., Zetterström, H. N. Engl. J. Med. (1978) [Pubmed]
  23. Effects of dimethyl sulfoxide on renal function in man. Muther, R.S., Bennett, W.M. JAMA (1980) [Pubmed]
  24. Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin). Young, J.D., Damiano, A., DiNome, M.A., Leong, L.G., Cohn, Z.A. J. Exp. Med. (1987) [Pubmed]
  25. Hemolytic anemia induced by murine erythroblastosis virus: possible mechanisms of hemolysis and effects of an interferon inducer. Slamon, D.J. J. Natl. Cancer Inst. (1975) [Pubmed]
  26. Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype. Nishimura Ji, n.u.l.l., Phillips, K.L., Ware, R.E., Hall, S., Wilson, L., Gentry, T.L., Howard, T.A., Murakami, Y., Shibano, M., Machii, T., Gilboa, E., Kanakura, Y., Takeda, J., Kinoshita, T., Rosse, W.F., Smith, C.A. Blood (2001) [Pubmed]
  27. Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals. Araten, D.J., Nafa, K., Pakdeesuwan, K., Luzzatto, L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. Effects of glucose-6-phosphate dehydrogenase deficiency upon sickle cell anemia. Steinberg, M.H., West, M.S., Gallagher, D., Mentzer, W. Blood (1988) [Pubmed]
  29. Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Tolosano, E., Hirsch, E., Patrucco, E., Camaschella, C., Navone, R., Silengo, L., Altruda, F. Blood (1999) [Pubmed]
  30. Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. Tschopp, J., Chonn, A., Hertig, S., French, L.E. J. Immunol. (1993) [Pubmed]
  31. Amino acid residues 1101-1105 of the isotypic region of human C4B is important to the covalent binding activity of complement component C4. Reilly, B.D., Levine, R.P., Skanes, V.M. J. Immunol. (1991) [Pubmed]
  32. Massive hemolysis caused by acetaminophen. Positive determination by direct Coombs test. Manor, E., Marmor, A., Kaufman, S., Leiba, H. JAMA (1976) [Pubmed]
  33. The predictive value of serum haptoglobin in hemolytic disease. Marchand, A., Galen, R.S., Van Lente, F. JAMA (1980) [Pubmed]
  34. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. Nicolas, G., Chauvet, C., Viatte, L., Danan, J.L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., Vaulont, S. J. Clin. Invest. (2002) [Pubmed]
  35. Association of phosphofructokinase and aldolase with the membrane of the intact erythrocyte. Jenkins, J.D., Madden, D.P., Steck, T.L. J. Biol. Chem. (1984) [Pubmed]
  36. Mitomycin-associated renal failure. Case report and review. Hamner, R.W., Verani, R., Weinman, E.J. Arch. Intern. Med. (1983) [Pubmed]
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