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Chemical Compound Review

Darstine     5-methyl-1-(1-methyl-3,4,5,6- tetrahydro-2H...

Synonyms: Piperphenamine, CHEMBL2074659, NSC-17126, AC1L1VLA, NSC17126, ...
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High impact information on MEPIPERPHENIDOL

  • Inhibition by mepiperphenidol, a classical organic cation transport inhibitor, was observed with an IC50 value of 24 microM [1].
  • The perturbation of calcium homeostasis could be blocked by the addition of mepiperphenidol, an inhibitor of the organic cation transport system [2].
  • Finally, basolateral membrane potential was depolarized in a concentration-dependent manner by addition of 100-500 microM TEA or Darstine [3].


  1. Mechanism of vancomycin transport in the kidney: studies in rabbit renal brush border and basolateral membrane vesicles. Sokol, P.P. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  2. Gentamicin-induced increases in cytosolic calcium in pig kidney cells (LLC-PK1). Holohan, P.D., Sokol, P.P., Ross, C.R., Coulson, R., Trimble, M.E., Laska, D.A., Williams, P.D. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  3. Membrane potential drives organic cation transport into teleost renal proximal tubules. Smith, P.M., Pritchard, J.B., Miller, D.S. Am. J. Physiol. (1988) [Pubmed]
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