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Chemical Compound Review

AC1L1VLD     5-methyl-1-(1-methyl-3,4,5,6- tetrahydro-2H...

Synonyms: AC1Q779R, 13004-75-6, UNII-8I07J24F45
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High impact information on MEPIPERPHENIDOL

  • AZT inhibited pH-driven [3H]N'-methylnicotinamide transport (pHi = 6.0, pH0 = 7.5), but not as effectively as mepiperphenidol (MEPI), a known organic cation transport blocker; the corresponding IC50 values for AZT and MEPI were 2500 and 25 microM, respectively [1].
  • Counterflow studies, which examined the capability of the drug to cross the plasma membrane, indicated that [3H] tetraethylammonium and MEPI trans-stimulated [3H]tetraethyl-ammonium uptake, but AZT did not [1].


  1. Effect of 3'-azido-3'-deoxythymidine (AZT) on organic ion transport in rat renal brush border membrane vesicles. Griffiths, D.A., Hall, S.D., Sokol, P.P. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
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