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Chemical Compound Review:

CCRIS 3213 N-(2-hydroxypropyl)-N-methyl- nitrous amide

Synonyms: KST-1B8623, AC1Q2BVM, AR-1B9484, AKOS006275495, AC1L32MJ, ...

Lijinsky, W. et al., Mori, Y. et al., Chen, S.C. et al., Yamamoto, K. et al.

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Disease relevance of CCRIS 3213

Of the 14 hamsters treated with the higher dose of nitrosomethyl-2-hydroxypropylamine (NMHP) and surviving beyond 6 weeks, most had liver neoplasms and nine had neoplasms of the pancreatic ducts [1].

High impact information on CCRIS 3213

Besides the 3 N-nitrosopropylamines, N-nitrosomethyl(2-hydroxypropyl)amine (MHP) was also positive in the presence of lung S9 from polychlorinated biphenyl (PCB)-induced rats, hamsters and mice [2].
Dose-response study of N-nitrosomethyl(2-hydroxypropyl)amine-induced nasal cavity carcinogenesis in rats [3].

Analytical, diagnostic and therapeutic context of CCRIS 3213

The principal MOP metabolite was identified as methyl-2-hydroxypropylnitrosamine (MHP) by its HPLC behavior and its 1H-NMR and mass spectra [4].

References

Carcinogenesis by oxygenated nitrosomethylpropylamines in Syrian hamsters. Lijinsky, W., Kovatch, R.M., Knutsen, G.L. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
Activation of carcinogenic N-nitrosopropylamines to mutagens by lung and pancreas S9 fractions from various animal species and man. Mori, Y., Yamazaki, H., Toyoshi, K., Maruyama, H., Konishi, Y. Mutat. Res. (1986) [Pubmed]
Dose-response study of N-nitrosomethyl(2-hydroxypropyl)amine-induced nasal cavity carcinogenesis in rats. Yamamoto, K., Nakajima, A., Eimoto, H., Takashima, Y., Tsujiuchi, T., Sugimura, M., Konishi, Y. Experimental pathology. (1990) [Pubmed]
Metabolism of the hamster pancreatic carcinogen methyl-2-oxopropylnitrosamine by hamster liver and pancreas. Chen, S.C., Wang, X., Zhou, L., Kolar, C., Lawson, T.A., Mirvish, S.S. Int. J. Pancreatol. (2000) [Pubmed]

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