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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nasal Cavity

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Disease relevance of Nasal Cavity


High impact information on Nasal Cavity


Chemical compound and disease context of Nasal Cavity


Biological context of Nasal Cavity


Anatomical context of Nasal Cavity


Associations of Nasal Cavity with chemical compounds


Gene context of Nasal Cavity

  • These findings demonstrate that Fgf8 is crucial for proper development of the OE, nasal cavity and VNO, as well as maintenance of OE neurogenesis during prenatal development [17].
  • Little to no immunoreactivity with CYP1A1 antibody was observed in fixed nasal sections of control rats, yet intense immunoreactivity was seen in epithelia throughout the nasal cavity of MCS-exposed rats [29].
  • Phosphacan, unlike neurocan, was present within the mesenchyme surrounding the E11.5 and E12.5 nasal cavity [30].
  • In the present study, the regional distribution and cell-specific expression of CYP2A in the rat nasal cavity were examined using an antibody to rabbit CYP2A10/11 [31].
  • Despite a normal spatial pattern of DBA-stained neurons within the nasal cavity, there was a distorted axonal projection of these neurons onto the surface of the olfactory bulb in N-CAM-180 null mutants [32].

Analytical, diagnostic and therapeutic context of Nasal Cavity


  1. Nasal cancer in a worker exposed to formaldehyde. Halperin, W.E., Goodman, M., Stayner, L., Elliott, L.J., Keenlyside, R.A., Landrigan, P.J. JAMA (1983) [Pubmed]
  2. Carcinogenesis in F344 rats by N-nitrosomethyl-n-propylamine derivatives. Lijinsky, W., Reuber, M.D., Saavedra, J.E., Singer, G.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  3. Immunohistochemical diagnosis of olfactory neuroblastoma. Choi, H.S., Anderson, P.J. J. Neuropathol. Exp. Neurol. (1985) [Pubmed]
  4. Non-lethal infection of aminergic reticular core neurons: age-dependent spread of ts mutant vesicular stomatitis virus from the nose. Lundh, B., Löve, A., Kristensson, K., Norrby, E. J. Neuropathol. Exp. Neurol. (1988) [Pubmed]
  5. TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Perrone, F., Oggionni, M., Birindelli, S., Suardi, S., Tabano, S., Romano, R., Moiraghi, M.L., Bimbi, G., Quattrone, P., Cantu, G., Pierotti, M.A., Licitra, L., Pilotti, S. Int. J. Cancer (2003) [Pubmed]
  6. Multiple functions for Pax6 in mouse eye and nasal development. Quinn, J.C., West, J.D., Hill, R.E. Genes Dev. (1996) [Pubmed]
  7. Ultrastructural localization of olfactory transduction components: the G protein subunit Golf alpha and type III adenylyl cyclase. Menco, B.P., Bruch, R.C., Dau, B., Danho, W. Neuron (1992) [Pubmed]
  8. Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling propylene oxide for up to two years. Renne, R.A., Giddens, W.E., Boorman, G.A., Kovatch, R., Haseman, J.E., Clarke, W.J. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. Microautoradiographic localization of bound metabolites in the nasal cavities of F344 rats treated with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Tjälve, H., Castonguay, A., Rivenson, A. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Carcinogenicity of diallylnitrosamine following intragastric administration to Syrian hamsters. Grandjean, C.J., Althoff, J., Pour, P.M. J. Natl. Cancer Inst. (1985) [Pubmed]
  11. Nasal carcinomas in beagles after inhalation of relatively soluble forms of beta-emitting radionuclides. Benjamin, S.A., Boecker, B.B., Cuddihy, R.G., McClellan, R.O. J. Natl. Cancer Inst. (1979) [Pubmed]
  12. Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats. Tanida, M., Niijima, A., Shen, J., Nakamura, T., Nagai, K. Neurosci. Lett. (2006) [Pubmed]
  13. Effect of peripheral anosmia in dogs trained as flavor validators. Houpt, K.A., Davis, P.P., Hintz, H.F. Am. J. Vet. Res. (1982) [Pubmed]
  14. Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Thorgeirsson, U.P., Dalgard, D.W., Reeves, J., Adamson, R.H. Regulatory toxicology and pharmacology : RTP. (1994) [Pubmed]
  15. Malignant triton tumor of the nasal cavity. Kim, S.T., Kim, C.W., Han, G.C., Park, C., Jang, I.H., Cha, H.E., Choi, G., Lee, H.M. Head & neck. (2001) [Pubmed]
  16. Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection. van Ginkel, F.W., McGhee, J.R., Watt, J.M., Campos-Torres, A., Parish, L.A., Briles, D.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Kawauchi, S., Shou, J., Santos, R., Hébert, J.M., McConnell, S.K., Mason, I., Calof, A.L. Development (2005) [Pubmed]
  18. Nerve growth factor and substance P regulation in nasal sensory neurons after toluene diisocyanate exposure. Wilfong, E.R., Dey, R.D. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  19. Odorant-dependent, spatially restricted induction of c-fos in the olfactory epithelium of the mouse. Norlin, E.M., Vedin, V., Bohm, S., Berghard, A. J. Neurochem. (2005) [Pubmed]
  20. A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine. Pour, P., Althoff, J., Krüger, F.W., Mohr, U. J. Natl. Cancer Inst. (1977) [Pubmed]
  21. Carcinogenicity of N-nitroso-3,4-dichloro- and n-nitroso-3,4-dibromopiperidine in rats. Lijinsky, W., Taylor, H.W. Cancer Res. (1975) [Pubmed]
  22. Unilateral naris closure and olfactory system development. Brunjes, P.C. Brain Res. Brain Res. Rev. (1994) [Pubmed]
  23. Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects. Nelson, D.K., Williams, T. Dev. Biol. (2004) [Pubmed]
  24. Role of galectin-1 in the developing mouse olfactory system. Puche, A.C., Poirier, F., Hair, M., Bartlett, P.F., Key, B. Dev. Biol. (1996) [Pubmed]
  25. Prevention of N-nitrosobis(2-oxopropyl)amine-induced nasal cavity tumors in rats by orchiectomy. Pour, P.M., Götz, U. J. Natl. Cancer Inst. (1983) [Pubmed]
  26. Tumorigenesis by oxygenated nitrosopiperidines in rats. Lijinsky, W., Taylor, H.W. J. Natl. Cancer Inst. (1975) [Pubmed]
  27. Pathogenesis of tumors induced with N-nitrosomethylpiperazine in the olfactory region of the rat nasal cavity. Reznik-Schüller, H.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  28. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Belinsky, S.A., White, C.M., Boucheron, J.A., Richardson, F.C., Swenberg, J.A., Anderson, M. Cancer Res. (1986) [Pubmed]
  29. Effect of cigarette smoke on CYP1A1, CYP1A2 and CYP2B1/2 of nasal mucosae in F344 rats. Wardlaw, S.A., Nikula, K.J., Kracko, D.A., Finch, G.L., Thornton-Manning, J.R., Dahl, A.R. Carcinogenesis (1998) [Pubmed]
  30. Dynamic spatiotemporal expression patterns of neurocan and phosphacan indicate diverse roles in the developing and adult mouse olfactory system. Clarris, H.J., Rauch, U., Key, B. J. Comp. Neurol. (2000) [Pubmed]
  31. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Thornton-Manning, J.R., Nikula, K.J., Hotchkiss, J.A., Avila, K.J., Rohrbacher, K.D., Ding, X., Dahl, A.R. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  32. The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform. Treloar, H., Tomasiewicz, H., Magnuson, T., Key, B. J. Neurobiol. (1997) [Pubmed]
  33. The value of acoustic rhinometry in assessing nasal responses to cat exposure. Phipatanakul, W., Kesavanathan, J., Eggleston, P.A., Johnson, E.F., Wood, R.A. J. Allergy Clin. Immunol. (1998) [Pubmed]
  34. Toluene diisocyanate enhances substance P in sensory neurons innervating the nasal mucosa. Hunter, D.D., Satterfield, B.E., Huang, J., Fedan, J.S., Dey, R.D. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  35. Dehydroepiandrosterone regulates astroglia reaction to denervation of olfactory glomeruli. Hoyk, Z., Párducz, A., Garcia-Segura, L.M. Glia (2004) [Pubmed]
  36. Pituitary adenylate cyclase-activating polypeptide, effects in the human nose. Kinhult, J., Adner, M., Uddman, R., Cardell, L.O. Clin. Exp. Allergy (2003) [Pubmed]
  37. Accumulation of Ym1/2 protein in the mouse olfactory epithelium during regeneration and aging. Giannetti, N., Moyse, E., Ducray, A., Bondier, J.R., Jourdan, F., Propper, A., Kastner, A. Neuroscience (2004) [Pubmed]
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