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Disease relevance of Cricetinae

  • The brains of Tg(MH2M PrP) mice dying of scrapie contained chimeric PrPSc and prions with an artificial host range favoring propagation in mice that express the corresponding chimeric PrP and were also transmissible, at reduced efficiency, to nontransgenic mice and hamsters [1].
  • Mutagenization of measles virus with proflavine produced a temperature-sensitive mutant capable of inducing hydrocephalus following intracranial inoculation of newborn hamsters [2].
  • Lung cancers have been induced in 9 to 53 percent of hamsters given multiple intratracheal instillations of polonium-210 in amounts yielding lifetime exposures of 15 to 300 rads to the lungs [3].
  • Ribavirin, when given to pregnant hamsters in relatively small single doses, induces congenital anomalies of limbs, ribs, eyes, and central nervous system, as well as fetal deaths [4].
  • Pregnant hamsters at 10-11 days of gestation were given injections ip of 3 mg diethylnitrosamine (DENA)/100 g body weight and were killed 2 days later when fetal cells were seeded for colony formation [5].

Psychiatry related information on Cricetinae

  • The prion protein (PrP) is a scrapie-associated fibril protein that accumulates in the brains of hamsters and mice infected with the scrapie agent, and also in the brains of persons affected with kuru or Creutzfeldt-Jakob disease [6].
  • Three daily injections of the short-acting benzodiazepine, triazolam, induced pronounced phase shifts in the onset of both the circadian surge in pituitary LH release and the circadian rhythm of locomotor activity in ovariectomized hamsters treated with estrogen [7].
  • The histopathological features of eye disease in hamsters were different from those in rats and were characterized by microophthalmia (especially in runted hamsters) and abnormal proliferation, disorientation, and disorganization of corneal, lens, and retinal tissues [8].
  • Reserpine and prochlorperazine were administered in separate experiments to adult CAW:CF1 mice and to adult LVG:LAK hamsters that had recovered from audiosensitization induced by 30 sec of doorbell sound during a critical period of infantile development [9].
  • On the other hand, astressin 2B did not prevent the inhibition of behavior induced by 48-h food deprivation or ICV administration of CRF, a mixed CRFR1 and CRFR2 agonist, suggesting that activation of CRFR1 signaling is sufficient to inhibit sexual receptivity in hamsters [10].

High impact information on Cricetinae

  • SV40 infection or transformation of murine cells stimulated the production of a 54K dalton protein that was specifically immunoprecipitated, along with SV40 large T and small t antigens, with sera from mice or hamsters bearing SV40-induced tumors [11].
  • Notably, serial PMCA enables detection of PrP(Sc) in blood samples of scrapie-afflicted hamsters with 89% sensitivity and 100% specificity [12].
  • Treatment of hyperlipidemic hamsters with BBR reduced serum cholesterol by 40% and LDL-cholesterol by 42%, with a 3.5-fold increase in hepatic LDLR mRNA and a 2.6-fold increase in hepatic LDLR protein [13].
  • When administered to hyperlipidemic hamsters, SCAP ligands reduced both LDL cholesterol and triglycerides levels by up to 80% with a three-fold increase in LDLr mRNA in the livers [14].
  • LRP levels, however, were dramatically increased in brain and pancreas, slightly increased in the spleen and not altered in the liver of crapie-infected hamsters [15].

Chemical compound and disease context of Cricetinae

  • Here we report that treatment of scrapie-infected hamsters with amphotericin B delays the accumulation in the brain of the proteinase-resistant portion of PrPSc by about 30 days without affecting scrapie replication [16].
  • P8 80-100% incidence of multinodular hepatocellular carcinomas was observed in castrated male hamsters following synthetic estrogen treatment in the presence of 0.2-0.4% alpha-naphthoflavone (ANF) in the diet after 8.5-10 months [17].
  • Bleomycin-induced pulmonary fibrosis in hamsters is associated with collagen accumulation that results from increased lung collagen synthesis rates [18].
  • Simian virus 40 (SV40)-specific isoelectric point-4.7--94,000-Mr membrane glycoprotein: major peptide homology exhibited with the nuclear and membrane-associated 94,000-Mr SV40 T-antigen in hamsters [19].
  • The incidence of hepatic necrosis was elevated in BOP-treated hamsters fed the unsupplemented diet, and that of biliary cystic adenomas was highest in the group fed 0.1 ppm Se before and after BOP treatment [20].

Biological context of Cricetinae


Anatomical context of Cricetinae


Associations of Cricetinae with chemical compounds

  • But melatonin can make people drowsy and triazolam often induces hamsters to run in their wheels [31].
  • In hamsters, injections of triazolam, a benzodiazepine, increase the rate of adjustment of activity rhythms to an 8 h advance of the light-dark (LD) cycle [31].
  • The consequence is that hamsters treated with amphotericin B developed clinical signs of disease later than infected controls [16].
  • Previous studies have shown a complete absence of cortico-spinal tract regeneration after the first postnatal week in rats, and in adult hamsters and cats [32].
  • The natural hormone 17 beta-estradiol (E2) induces tumors in various organs of rats, mice, and hamsters [33].

Gene context of Cricetinae

  • In hamsters, BNP and ANP occur mainly in the ventricle and the atrium, respectively [34].
  • Cholesterol feeding reduces the mRNAs encoding multiple enzymes in the cholesterol biosynthetic pathway and the low density lipoprotein receptor in livers of hamsters [35].
  • We show that livers of hamsters, like those of mice and humans, predominantly produce SREBP-2 and the 1c isoform of SREBP-1 [35].
  • It encodes a novel hydrophobic protein, designated DAD1, which is well conserved (100% identical amino acids between humans and hamsters) [36].
  • Cellular sequences which were free of repeated DNA derived from a clone that defines the Mlvi -2 integration domain (lambda Cl228 ) were found to be highly conserved in a variety of vertebrate species that we examined, including mice, hamsters, cats, and humans [37].

Analytical, diagnostic and therapeutic context of Cricetinae


  1. Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes. Scott, M., Groth, D., Foster, D., Torchia, M., Yang, S.L., DeArmond, S.J., Prusiner, S.B. Cell (1993) [Pubmed]
  2. Measles virus: an unwanted variant causing hydrocephalus. Haspel, M.V., Rapp, F. Science (1975) [Pubmed]
  3. Lung cancer induced in hamsters by low doses of alpha radiation from polonium-210. Little, J.B., Kennedy, A.R., McGandy, R.B. Science (1975) [Pubmed]
  4. Congenital anomalies induced in hamster embryos with ribavirin. Kilham, L., Ferm, V.H. Science (1977) [Pubmed]
  5. Lymphotoxin prevention of diethylnitrosamine carcinogenesis in vivo. Ransom, J.H., Evans, C.H., DiPaolo, J.A. J. Natl. Cancer Inst. (1982) [Pubmed]
  6. Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. Locht, C., Chesebro, B., Race, R., Keith, J.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  7. The circadian rhythm of LH release can be shifted by injections of a benzodiazepine in female golden hamsters. Turek, F.W., Losee-Olson, S. Endocrinology (1988) [Pubmed]
  8. Pathogenicity of Spiroplasma sp. strain SMCA in Syrian hamsters: clinical, microbiological, and histological aspects. Kirchhoff, H., Kuwabara, T., Barile, M.F. Infect. Immun. (1981) [Pubmed]
  9. Infantile auditory exposure and unusual response to antipsychiotic drugs (38510). Iturrian, W.B., Johnson, H.D. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  10. Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters. Seymour, P.L., Dettloff, S.L., Jones, J.E., Wade, G.N. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  11. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Linzer, D.I., Levine, A.J. Cell (1979) [Pubmed]
  12. Detection of prions in blood. Castilla, J., Saá, P., Soto, C. Nat. Med. (2005) [Pubmed]
  13. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., Jiang, J.D. Nat. Med. (2004) [Pubmed]
  14. SCAP ligands are potent new lipid-lowering drugs. Grand-Perret, T., Bouillot, A., Perrot, A., Commans, S., Walker, M., Issandou, M. Nat. Med. (2001) [Pubmed]
  15. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Rieger, R., Edenhofer, F., Lasmézas, C.I., Weiss, S. Nat. Med. (1997) [Pubmed]
  16. Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Xi, Y.G., Ingrosso, L., Ladogana, A., Masullo, C., Pocchiari, M. Nature (1992) [Pubmed]
  17. High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian golden hamsters fed alpha-naphthoflavone: a new tumor model. Li, J.J., Li, S.A. J. Natl. Cancer Inst. (1984) [Pubmed]
  18. Bleomycin-induced pulmonary fibrosis in hamsters. An alveolar macrophage product increases fibroblast prostaglandin E2 and cyclic adenosine monophosphate and suppresses fibroblast proliferation and collagen production. Clark, J.G., Kostal, K.M., Marino, B.A. J. Clin. Invest. (1983) [Pubmed]
  19. Simian virus 40 (SV40)-specific isoelectric point-4.7--94,000-Mr membrane glycoprotein: major peptide homology exhibited with the nuclear and membrane-associated 94,000-Mr SV40 T-antigen in hamsters. Schmidt-Ullrich, R., Thompson, W.S., Kahn, S.J., Monroe, M.T., Wallach, D.F. J. Natl. Cancer Inst. (1982) [Pubmed]
  20. Effects of dietary selenium on bis(2-oxopropyl)nitrosamine-induced carcinogenesis in Syrian golden hamsters. Birt, D.F., Julius, A.D., Runice, C.E., Salmasi, S. J. Natl. Cancer Inst. (1986) [Pubmed]
  21. Estradiol shortens the period of hamster circadian rhythms. Morin, L.P., Fitzgerald, K.M., Zucker, I. Science (1977) [Pubmed]
  22. DNA methylation decreases in aging but not in immortal cells. Wilson, V.L., Jones, P.A. Science (1983) [Pubmed]
  23. Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters. Roda, A., Pellicciari, R., Polimeni, C., Cerrè, C., Forti, G.C., Sadeghpour, B., Sapigni, E., Gioacchini, A.M., Natalini, B. Gastroenterology (1995) [Pubmed]
  24. The preventive effect of verapamil on ethanol-induced cardiac depression: phosphorus-31 nuclear magnetic resonance and high-pressure liquid chromatographic studies of hamsters. Wu, S., White, R., Wikman-Coffelt, J., Sievers, R., Wendland, M., Garrett, J., Higgins, C.B., James, T., Parmley, W.W. Circulation (1987) [Pubmed]
  25. Critical role of oxidative stress in estrogen-induced carcinogenesis. Bhat, H.K., Calaf, G., Hei, T.K., Loya, T., Vadgama, J.V. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Melatonin induction of gonadal quiescence in pinealectomized Syrian hamsters. Tamarkin, L., Hollister, C.W., Lefebvre, N.G., Goldman, B.D. Science (1977) [Pubmed]
  27. Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure. Blum, K., Briggs, A.H., Elston, S.F., DeLallo, L., Sheridan, P.J., Sar, M. Science (1982) [Pubmed]
  28. Metabolic activation by hamster and rat hepatocytes in the Salmonella mutagenicity assay. Poiley, J.A., Raineri, R., Andrews, A.W., Cavanaugh, D.M., Pienta, R.J. J. Natl. Cancer Inst. (1980) [Pubmed]
  29. Identification of atrial natriuretic factor within ventricular tissue in hamsters and humans with congestive heart failure. Edwards, B.S., Ackermann, D.M., Lee, M.E., Reeder, G.S., Wold, L.E., Burnett, J.C. J. Clin. Invest. (1988) [Pubmed]
  30. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. Kao, R.C., Wehner, N.G., Skubitz, K.M., Gray, B.H., Hoidal, J.R. J. Clin. Invest. (1988) [Pubmed]
  31. A behavioural method for accelerating re-entrainment of rhythms to new light-dark cycles. Mrosovsky, N., Salmon, P.A. Nature (1987) [Pubmed]
  32. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Schnell, L., Schwab, M.E. Nature (1990) [Pubmed]
  33. Is estradiol a genotoxic mutagenic carcinogen? Liehr, J.G. Endocr. Rev. (2000) [Pubmed]
  34. Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides. Tamura, N., Ogawa, Y., Itoh, H., Arai, H., Suga, S., Nakagawa, O., Komatsu, Y., Kishimoto, I., Takaya, K., Yoshimasa, T. J. Clin. Invest. (1994) [Pubmed]
  35. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Shimomura, I., Bashmakov, Y., Shimano, H., Horton, J.D., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  36. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Nakashima, T., Sekiguchi, T., Kuraoka, A., Fukushima, K., Shibata, Y., Komiyama, S., Nishimoto, T. Mol. Cell. Biol. (1993) [Pubmed]
  37. Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15. Tsichlis, P.N., Strauss, P.G., Kozak, C.A. Mol. Cell. Biol. (1984) [Pubmed]
  38. Induction of functional retinal projections to the somatosensory system. Frost, D.O., Metin, C. Nature (1985) [Pubmed]
  39. Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol. Turley, S.D., Spady, D.K., Dietschy, J.M. Gastroenterology (1983) [Pubmed]
  40. A fatal case of babesiosis in Missouri: identification of another piroplasm that infects humans. Herwaldt, B., Persing, D.H., Précigout, E.A., Goff, W.L., Mathiesen, D.A., Taylor, P.W., Eberhard, M.L., Gorenflot, A.F. Ann. Intern. Med. (1996) [Pubmed]
  41. Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture. Linnoila, R.I., Nettesheim, P., DiAugustine, R.P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
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