Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Daca N-(2- dimethylaminoethyl)acridine- 4...

Synonyms: DACA-N, CHEMBL9940, CCRIS 4457, CHEBI:105661, NSC-601316, ...

Robertson, I.G. et al., Robertson, I.G. et al., Osman, S. et al., Ferguson, L.R. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Acridine carboxamide

(N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (acridine carboxamide; NSC 601316) is an acridine-derived experimental antitumour agent with curative properties against Lewis lung carcinoma in mice [1].

High impact information on Acridine carboxamide

This study reports on the biodistribution and metabolism of the 11C-labeled novel antitumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) (also known as NSC 601316) in rats (plasma and tissues) and humans (plasma) [2].
Several drugs with structural similarities to SKF-525A were tested for their ability to inhibit rat liver aldehyde oxidase using the experimental antitumour agent N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (AC; NSC 601316; acridine carboxamide) as substrate [3].
Oxidation of the experimental anti-tumour agent N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (AC; NSC 601316; acridine carboxamide) to the 9(10H)acridone, followed by ring hydroxylation and glucuronidation, appears to be the main pathway of detoxication of AC in the rat and mouse [4].

References

Genetic toxicology of tricyclic carboxamides, a new class of DNA binding antitumour agent. Ferguson, L.R., Hill, C.M., Baguley, B.C. Eur. J. Cancer (1990) [Pubmed]
Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in rats and humans prior to phase I clinical trials. Osman, S., Luthra, S.K., Brady, F., Hume, S.P., Brown, G., Harte, R.J., Matthews, J.C., Denny, W.A., Baguley, B.C., Jones, T., Price, P.M. Cancer Res. (1997) [Pubmed]
Methadone: a potent inhibitor of rat liver aldehyde oxidase. Robertson, I.G., Gamage, R.S. Biochem. Pharmacol. (1994) [Pubmed]
Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Robertson, I.G., Bland, T.J. Biochem. Pharmacol. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share