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Chemical Compound Review

Daca     N-(2- dimethylaminoethyl)acridine- 4...

Synonyms: DACA-N, CHEMBL9940, CCRIS 4457, CHEBI:105661, NSC-601316, ...
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Disease relevance of Acridine carboxamide


High impact information on Acridine carboxamide

  • This study reports on the biodistribution and metabolism of the 11C-labeled novel antitumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) (also known as NSC 601316) in rats (plasma and tissues) and humans (plasma) [2].
  • Several drugs with structural similarities to SKF-525A were tested for their ability to inhibit rat liver aldehyde oxidase using the experimental antitumour agent N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (AC; NSC 601316; acridine carboxamide) as substrate [3].
  • Oxidation of the experimental anti-tumour agent N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (AC; NSC 601316; acridine carboxamide) to the 9(10H)acridone, followed by ring hydroxylation and glucuronidation, appears to be the main pathway of detoxication of AC in the rat and mouse [4].


  1. Genetic toxicology of tricyclic carboxamides, a new class of DNA binding antitumour agent. Ferguson, L.R., Hill, C.M., Baguley, B.C. Eur. J. Cancer (1990) [Pubmed]
  2. Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in rats and humans prior to phase I clinical trials. Osman, S., Luthra, S.K., Brady, F., Hume, S.P., Brown, G., Harte, R.J., Matthews, J.C., Denny, W.A., Baguley, B.C., Jones, T., Price, P.M. Cancer Res. (1997) [Pubmed]
  3. Methadone: a potent inhibitor of rat liver aldehyde oxidase. Robertson, I.G., Gamage, R.S. Biochem. Pharmacol. (1994) [Pubmed]
  4. Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Robertson, I.G., Bland, T.J. Biochem. Pharmacol. (1993) [Pubmed]
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