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MeSH Review

Carcinoma, Lewis Lung

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Disease relevance of Carcinoma, Lewis Lung


High impact information on Carcinoma, Lewis Lung


Chemical compound and disease context of Carcinoma, Lewis Lung


Biological context of Carcinoma, Lewis Lung


Anatomical context of Carcinoma, Lewis Lung


Gene context of Carcinoma, Lewis Lung

  • Our results show clearly that murine Lewis lung carcinoma cells overexpressing placenta growth factor-2, an Flt-1-specific ligand, grew in wild-type mice much faster than in Flt-1 tyrosine kinase domain-deficient mice [24].
  • We have investigated how these two factors contribute to tumor immune surveillance by studying the immunity of perforin-deficient mice against the progressor C57BL/6 Lewis lung carcinoma 3LL, which expresses no CD95 when cultured in vitro [25].
  • To evaluate lung tumor COX-2 modulation of antitumor immunity, we studied the antitumor effect of specific genetic or pharmacological inhibition of COX-2 in a murine Lewis lung carcinoma (3LL) model [26].
  • Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction [27].
  • Overexpression of angiopoietin-2 (Ang-2) in Lewis lung carcinoma and TA3 mammary carcinoma cells inhibited their ability to form metastatic tumors and prolonged the survival of mice injected with the corresponding transfectants [28].

Analytical, diagnostic and therapeutic context of Carcinoma, Lewis Lung


  1. gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice. Cao, Y., Chen, C., Weatherbee, J.A., Tsang, M., Folkman, J. J. Exp. Med. (1995) [Pubmed]
  2. Histopathology of the host response to Lewis lung carcinoma: modulation by pyran. Snodgrass, M.J., Morahan, P.S., Kaplan, A.M. J. Natl. Cancer Inst. (1975) [Pubmed]
  3. Proteolytic enzymes in tumor metastasis. II. Collagenase type IV activity in subcellular fractions of cloned tumor cell populations. Eisenbach, L., Segal, S., Feldman, M. J. Natl. Cancer Inst. (1985) [Pubmed]
  4. Effect of adriamycin and Corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. Dimitrov, N.V., Denny, T.N., Weisman, M.F., Cameron, D.G. J. Natl. Cancer Inst. (1979) [Pubmed]
  5. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Kuo, C.J., Farnebo, F., Yu, E.Y., Christofferson, R., Swearingen, R.A., Carter, R., von Recum, H.A., Yuan, J., Kamihara, J., Flynn, E., D'Amato, R., Folkman, J., Mulligan, R.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Kim, M.S., Kwon, H.J., Lee, Y.M., Baek, J.H., Jang, J.E., Lee, S.W., Moon, E.J., Kim, H.S., Lee, S.K., Chung, H.Y., Kim, C.W., Kim, K.W. Nat. Med. (2001) [Pubmed]
  7. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Mandelboim, O., Berke, G., Fridkin, M., Feldman, M., Eisenstein, M., Eisenbach, L. Nature (1994) [Pubmed]
  8. Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. Nakao, S., Kuwano, T., Tsutsumi-Miyahara, C., Ueda, S., Kimura, Y.N., Hamano, S., Sonoda, K.H., Saijo, Y., Nukiwa, T., Strieter, R.M., Ishibashi, T., Kuwano, M., Ono, M. J. Clin. Invest. (2005) [Pubmed]
  9. Derivatives of amsacrine: determinants required for high activity against Lewis lung carcinoma. Baguley, B.C., Finlay, G.J. J. Natl. Cancer Inst. (1988) [Pubmed]
  10. Inhibition of spleen cell cytotoxic capacity toward tumor by elevated prostaglandin E2 levels in mice bearing Lewis lung carcinoma. Young, M.R., Hoover, C.S. J. Natl. Cancer Inst. (1986) [Pubmed]
  11. Prostaglandin E production by Lewis lung carcinoma: mechanism for tumor establishment in vivo. Young, M.R., Knies, S. J. Natl. Cancer Inst. (1984) [Pubmed]
  12. Resistance of cultured Lewis lung carcinoma cell lines to tiazofurin. Finlay, G.J., Ching, L.M., Wilson, W.R., Baguley, B.C. J. Natl. Cancer Inst. (1987) [Pubmed]
  13. Inhibitory effects of heparin plus cortisone acetate on endothelial cell growth both in cultures and in tumor masses. Sakamoto, N., Tanaka, N.G., Tohgo, A., Osada, Y., Ogawa, H. J. Natl. Cancer Inst. (1987) [Pubmed]
  14. Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. Blood, C.H., Sasse, J., Brodt, P., Zetter, B.R. J. Cell Biol. (1988) [Pubmed]
  15. Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis. Xu, Y., Liu, Y.J., Yu, Q. Cancer Res. (2004) [Pubmed]
  16. Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes. Gelber, C., Plaksin, D., Vadai, E., Feldman, M., Eisenbach, L. Cancer Res. (1989) [Pubmed]
  17. Hematopoietic rescue via T-cell-dependent, endogenous granulocyte-macrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor-bearing mice. Maestroni, G.J., Covacci, V., Conti, A. Cancer Res. (1994) [Pubmed]
  18. Regulation of tumor-induced myelopoiesis and the associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma by prostaglandin E2. Young, M.R., Young, M.E., Kim, K. Cancer Res. (1988) [Pubmed]
  19. Leukocyte adhesion in angiogenic blood vessels. Role of E-selectin, P-selectin, and beta2 integrin in lymphotoxin-mediated leukocyte recruitment in tumor microvessels. Borgström, P., Hughes, G.K., Hansell, P., Wolitsky, B.A., Sriramarao, P. J. Clin. Invest. (1997) [Pubmed]
  20. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Torchilin, V.P., Rammohan, R., Weissig, V., Levchenko, T.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  21. Treating tumor-bearing mice with low-dose gamma-interferon plus tumor necrosis factor alpha to diminish immune suppressive granulocyte-macrophage progenitor cells increases responsiveness to interleukin 2 immunotherapy. Pak, A.S., Ip, G., Wright, M.A., Young, M.R. Cancer Res. (1995) [Pubmed]
  22. Amino acid metabolism in tumour-bearing mice. Rivera, S., Azcón-Bieto, J., López-Soriano, F.J., Miralpeix, M., Argilés, J.M. Biochem. J. (1988) [Pubmed]
  23. Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells. Lison, D., Knoops, B., Collette, C., Lauwerys, R. Biochem. Pharmacol. (1989) [Pubmed]
  24. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Hiratsuka, S., Maru, Y., Okada, A., Seiki, M., Noda, T., Shibuya, M. Cancer Res. (2001) [Pubmed]
  25. Tumor immunity in perforin-deficient mice: a role for CD95 (Fas/APO-1). Rosen, D., Li, J.H., Keidar, S., Markon, I., Orda, R., Berke, G. J. Immunol. (2000) [Pubmed]
  26. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. Stolina, M., Sharma, S., Lin, Y., Dohadwala, M., Gardner, B., Luo, J., Zhu, L., Kronenberg, M., Miller, P.W., Portanova, J., Lee, J.C., Dubinett, S.M. J. Immunol. (2000) [Pubmed]
  27. Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. Saijo, Y., Tanaka, M., Miki, M., Usui, K., Suzuki, T., Maemondo, M., Hong, X., Tazawa, R., Kikuchi, T., Matsushima, K., Nukiwa, T. J. Immunol. (2002) [Pubmed]
  28. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. Yu, Q., Stamenkovic, I. Am. J. Pathol. (2001) [Pubmed]
  29. Loss of expression of transplantation antigens encoded by the H-2K locus on Lewis lung carcinoma cells and its relevance to the tumor's metastatic properties. Isakov, N., Katzav, S., Feldman, M., Segal, S. J. Natl. Cancer Inst. (1983) [Pubmed]
  30. Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide. Burres, N.S., Clement, J.J. Cancer Res. (1989) [Pubmed]
  31. Effects of interleukin 2 treatment combined with local hyperthermia in mice inoculated with Lewis lung carcinoma cells. Shen, R.N., Lu, L., Wu, B., Shidnia, H., Hornback, N.B., Broxmeyer, H.E. Cancer Res. (1990) [Pubmed]
  32. Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline. Ohira, T., Ohe, Y., Heike, Y., Podack, E.R., Olsen, K.J., Nishio, K., Nishio, M., Miyahara, Y., Funayama, Y., Ogasawara, H. Gene Ther. (1994) [Pubmed]
  33. Cu/Zn superoxide dismutase plays a role in angiogenesis. Marikovsky, M., Nevo, N., Vadai, E., Harris-Cerruti, C. Int. J. Cancer (2002) [Pubmed]
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