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Chemical Compound Review:

CCRIS 3042 (1R,2S)-6-amino-1,2- dihydrochrysene-1,2-diol

Synonyms: LS-53579, AC1L32Y8, 117760-93-7, 6-Aminochrysene-1,2-dihydrodiol, trans-6-Aminochrysene-1,2-dihydrodiol, ...

Chae, Y.H. et al., Yamazaki, H. et al.

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High impact information on CCRIS 3042

The major metabolites identified in 11 hepatic microsomes were trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene, trans-9,10-dihydro-9,10-dihydroxy-6-nitrochrysene, trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene, 6-aminochrysene, and chrysene-5,6-quinone [1].
Previous studies have indicated that the major metabolic activation pathway of 6-nitrochrysene in newborn mice is initially through the formation of the proximate tumorigen trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene with subsequent formation of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-aminochrysene [1].
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450 [2].

References

Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene. Chae, Y.H., Yun, C.H., Guengerich, F.P., Kadlubar, F.F., el-Bayoumy, K. Cancer Res. (1993) [Pubmed]
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. Yamazaki, H., Mimura, M., Oda, Y., Gonzalez, F.J., el-Bayoumy, K., Chae, Y.H., Guengerich, F.P., Shimada, T. Carcinogenesis (1994) [Pubmed]

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