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Chemical Compound Review:

PubChem3357 N-(2-nitrophenyl)ethanamide

Synonyms: zlchem 447, AURORA 5474, SureCN733777, NSC-1313, ACMC-1ARSI, ...

Weitnauer, E. et al., Manoharan, I. et al., Darvesh, S. et al.

Darvesh, McDonald, Darvesh, Mataija, Mothana, Cook, Carneiro, Richard, Walsh, Martin, Manoharan, Boopathy,

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High impact information on NSC1313

Butyrylcholinesterase in human plasma and acetylcholinesterase in human red blood cells have aryl acylamidase activity toward o-nitroacetanilide, hydrolyzing the amide bond to produce o-nitroaniline and acetate [1].
Several side activities have been attributed to butyrylcholinesterase (BChE), including aryl acylamidase (AAA) activity, which is an amidase-like activity with unknown physiological function splitting the artificial substrate o-nitroacetanilide [2].

Biological context of NSC1313

Also, larger N-(2-nitrophenyl)alkylamides were found to be more rapidly hydrolyzed by BuChE than N-(2-nitrophenyl)acetamide and, in addition, were more specific for hydrolysis by BuChE [3].

References

Diisopropylfluorophosphate-sensitive aryl acylamidase activity of fatty acid free human serum albumin. Manoharan, I., Boopathy, R. Arch. Biochem. Biophys. (2006) [Pubmed]
Aryl acylamidase activity exhibited by butyrylcholinesterase is higher in chick than in horse, but much lower than in fetal calf serum. Weitnauer, E., Robitzki, A., Layer, P.G. Neurosci. Lett. (1998) [Pubmed]
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases. Darvesh, S., McDonald, R.S., Darvesh, K.V., Mataija, D., Mothana, S., Cook, H., Carneiro, K.M., Richard, N., Walsh, R., Martin, E. Bioorg. Med. Chem. (2006) [Pubmed]

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