Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ANATABINE 3-[(2S)-1,2,3,6- tetrahydropyridin-2...

Synonyms: SureCN229515, HMDB04476, LS-19299, FT-0662155, AC1L1X94, ...

Carmella, S.G. et al., Riebe, M. et al., Hoffmann, D. et al.

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High impact information on ANATABINE

In a second experiment, we used an identical protocol to compare the endogenous nitrosation of this (S)-nicotine with that of synthetic (R,S)-nicotine, which did not contain detectable amounts of nornicotine, anabasine or anatabine [1].
Of five tobacco alkaloids tested, only anatabine led to a dose-dependent enhancement of the number of sister-chromatid exchanges (SCE) in Chinese hamster ovary cells (CHO) [2].

Associations of ANATABINE with other chemical compounds

N'-Nitrosoanatabine is formed by nitrosation of the second most abundant tobacco alkaloid, anatabine [3].

References

Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carmella, S.G., Borukhova, A., Desai, D., Hecht, S.S. Carcinogenesis (1997) [Pubmed]
Studies on the induction of sister-chromatid exchanges in Chinese hamster ovary cells by various tobacco alkaloids. Riebe, M., Westphal, K. Mutat. Res. (1983) [Pubmed]
Chemical studies on tobacco smoke LXVIII. Analysis of volatile and tobacco-specific nitrosamines in tobacco products. Hoffmann, D., Adams, J.D., Piade, J.J., Hecht, S.S. IARC Sci. Publ. (1980) [Pubmed]

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