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Disease relevance of Nitrosation


Psychiatry related information on Nitrosation

  • These data suggest that individual differences in oral nitrate reduction are a significant factor in gastric nitrosation and account for a large proportion of the interindividual variability in nitrosoamino acid excretion [6].
  • Because of the genotoxic effects shown by Dimethophrine (DMP) nitrosation mixtures, the interaction between DMP hydrochloride and sodium nitrite in acidic aqueous solution at 37 degrees was investigated in a wide range of reagent concentrations and molar ratios, reaction times and pH values [7].

High impact information on Nitrosation


Chemical compound and disease context of Nitrosation


Biological context of Nitrosation


Anatomical context of Nitrosation


Associations of Nitrosation with chemical compounds


Gene context of Nitrosation


Analytical, diagnostic and therapeutic context of Nitrosation


  1. Spermidine nitrosation and gastric cancer. Correa, P., Kokatnur, M.G., Murray, M.L. Lancet (1978) [Pubmed]
  2. Catalysis of nitrosyl transfer reactions by a dissimilatory nitrite reductase (cytochrome c,d1). Kim, C.H., Hollocher, T.C. J. Biol. Chem. (1984) [Pubmed]
  3. A novel mechanism for upregulation of the Escherichia coli K-12 hmp (flavohaemoglobin) gene by the 'NO releaser', S-nitrosoglutathione: nitrosation of homocysteine and modulation of MetR binding to the glyA-hmp intergenic region. Membrillo-Hernández, J., Coopamah, M.D., Channa, A., Hughes, M.N., Poole, R.K. Mol. Microbiol. (1998) [Pubmed]
  4. Synthesis and antihypertensive activity of 5-thio-2-pyridinecarboxylic acid derivatives. Finch, N., Campbell, T.R., Gemenden, C.W., Antonaccio, M.J., Povalski, H.J. J. Med. Chem. (1978) [Pubmed]
  5. Protection against peroxynitrite. Arteel, G.E., Briviba, K., Sies, H. FEBS Lett. (1999) [Pubmed]
  6. Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans. Shapiro, K.B., Hotchkiss, J.H., Roe, D.A. Food Chem. Toxicol. (1991) [Pubmed]
  7. Formation of 2,6-dimethoxy-1,4-benzoquinone, a highly genotoxic compound, from the reaction of sodium nitrite with the sympathomimetic drug dimethophrine in acidic aqueous solution. Mazzei, M., Roma, G., Balbi, A., Sottofattori, E., Robbiano, L. Il Farmaco; edizione scientifica. (1988) [Pubmed]
  8. N-nitrosation of proline in smokers and nonsmokers. Ladd, K.F., Newmark, H.L., Archer, M.C. J. Natl. Cancer Inst. (1984) [Pubmed]
  9. Effects of ergothioneine, cysteine, and glutathione on nitrosation of secondary amines under physiologic conditions. Kunisaki, N., Hayashi, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  10. Kinetics of nitrosamine formation in the presence of micelle-forming surfactants. Okun, J.D., Archer, M.C. J. Natl. Cancer Inst. (1977) [Pubmed]
  11. Nitrite and thiocyanate in the fasting and secreting stomach and in saliva. Ruddell, W.S., Blendis, L.M., Walters, C.L. Gut (1977) [Pubmed]
  12. Nitrate and N-nitrosoproline excretion in two Italian regions with contrasting rates of gastric cancer: the role of nitrate and other factors in endogenous nitrosation. Knight, T., Pirastu, R., Palli, D., Cocco, P., Leach, S., Packer, P., Iannarilli, R., Manca, P., Møller, H., Forman, D. Int. J. Cancer (1992) [Pubmed]
  13. Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains. Calmels, S., Ohshima, H., Vincent, P., Gounot, A.M., Bartsch, H. Carcinogenesis (1985) [Pubmed]
  14. Nitrosation of glycine ethyl ester and ethyl diazoacetate to give the alkylating agent and mutagen ethyl chloro(hydroximino)acetate. Zhou, L., Haorah, J., Chen, S.C., Wang, X., Kolar, C., Lawson, T.A., Mirvish, S.S. Chem. Res. Toxicol. (2004) [Pubmed]
  15. Kinetics of nornicotine and anabasine nitrosation in relation to N'-nitrosonornicotine occurrence in tobacco and to tobacco-induced cancer. Mirvish, S.S., Sams, J., Hecht, S.S. J. Natl. Cancer Inst. (1977) [Pubmed]
  16. Nondetection of O6-methylguanine in rat DNA following in vivo treatment with large doses of cimetidine alone or in combination with sodium nitrite. Kyrtopoulos, S.A., Hadjiloucas, E., Vrotsou, B. Cancer Res. (1982) [Pubmed]
  17. Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides. Caulfield, J.L., Wishnok, J.S., Tannenbaum, S.R. J. Biol. Chem. (1998) [Pubmed]
  18. Interference of carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions. Pfeiffer, S., Leopold, E., Hemmens, B., Schmidt, K., Werner, E.R., Mayer, B. Free Radic. Biol. Med. (1997) [Pubmed]
  19. Dose-response study of N-nitrosoproline formation in rats and a deduced kinetic model for predicting carcinogenic effects caused by endogenous nitrosation. Ohshima, H., Mahon, G.A., Wahrendorf, J., Bartsch, H. Cancer Res. (1983) [Pubmed]
  20. Proline is not useful as a chemical probe to measure nitrosation in the gastrointestinal tract of patients with gastric disorders characterised by anacidic conditions. Adam, B., Schlag, P., Friedl, P., Preussmann, R., Eisenbrand, G. Gut (1989) [Pubmed]
  21. Urinary N-nitrosoproline excretion: a further evaluation of the nitrosamine hypothesis of gastric carcinogenesis in precancerous conditions. Hall, C.N., Kirkham, J.S., Northfield, T.C. Gut (1987) [Pubmed]
  22. Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress. Ogawa, R., Pacelli, R., Espey, M.G., Miranda, K.M., Friedman, N., Kim, S.M., Cox, G., Mitchell, J.B., Wink, D.A., Russo, A. Free Radic. Biol. Med. (2001) [Pubmed]
  23. Characterization and application of the biotin-switch assay for the identification of S-nitrosated proteins. Zhang, Y., Keszler, A., Broniowska, K.A., Hogg, N. Free Radic. Biol. Med. (2005) [Pubmed]
  24. Disappearance of nitrite from the rat stomach: contribution of emptying and other factors. Mirvish, S.S., Patil, K., Ghadirian, P., Kommineni, V.R. J. Natl. Cancer Inst. (1975) [Pubmed]
  25. Reaction of nitrite with ascorbate and its relation to nitrosamine formation. Archer, M.C., Tannenbaum, S.R., Fan, T.Y., Weisman, M. J. Natl. Cancer Inst. (1975) [Pubmed]
  26. Carcinogenicity of N'-nitrosonornicotine in Sprague-Dawley rats. Singer, G.M., Taylor, H.W. J. Natl. Cancer Inst. (1976) [Pubmed]
  27. Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach? Ruddell, W.S., Bone, E.S., Hill, M.J., Blendis, L.M., Walters, C.L. Lancet (1976) [Pubmed]
  28. Nitric oxide modification of rat brain neurogranin affects its phosphorylation by protein kinase C and affinity for calmodulin. Sheu, F.S., Mahoney, C.W., Seki, K., Huang, K.P. J. Biol. Chem. (1996) [Pubmed]
  29. Nitric oxide-derived nitrosating species and gene expression in human monocytic cells. Turpaev, K., Bouton, C., Drapier, J.C. Biochemistry (2004) [Pubmed]
  30. Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli. Ralt, D., Wishnok, J.S., Fitts, R., Tannenbaum, S.R. J. Bacteriol. (1988) [Pubmed]
  31. Inactivation of multiple targets by nitric oxide in CD95-triggered apoptosis. Bernassola, F., Catani, M.V., Corazzari, M., Rossi, A., Melino, G. J. Cell. Biochem. (2001) [Pubmed]
  32. Myeloperoxidase potentiates nitric oxide-mediated nitrosation. Lakshmi, V.M., Nauseef, W.M., Zenser, T.V. J. Biol. Chem. (2005) [Pubmed]
  33. Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation. Ungvari, Z., Csiszar, A., Bagi, Z., Koller, A. Am. J. Pathol. (2002) [Pubmed]
  34. Studies on the antimutagenic activity of ascorbic acid in vitro and in vivo. Norkus, E.P., Kuenzig, W.A. Carcinogenesis (1985) [Pubmed]
  35. Workgroup report: Drinking-water nitrate and health--recent findings and research needs. Ward, M.H., deKok, T.M., Levallois, P., Brender, J., Gulis, G., Nolan, B.T., VanDerslice, J. Environ. Health Perspect. (2005) [Pubmed]
  36. Tumor induction in a rat model for ureterosigmoidostomy without evidence of nitrosamine formation. Kälble, T., Tricker, A.R., Berger, M., Amelung, F., Waldherr, R., Hothorn, L., Möhring, K., Staehler, G. J. Urol. (1991) [Pubmed]
  37. Levels of direct-acting mutagens, total N-nitroso compounds in nitrosated fermented fish products, consumed in a high-risk area for gastric cancer in southern China. Chen, C.S., Pignatelli, B., Malaveille, C., Bouvier, G., Shuker, D., Hautefeuille, A., Zhang, R.F., Bartsch, H. Mutat. Res. (1992) [Pubmed]
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