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Chemical Compound Review:

AG-G-11731 trimethylstibane

Synonyms: CTK1H0942, LS-146735, AKOS015914836, FT-0653966, BRN 3902982, ...

Dopp, E. et al., Andrewes, P. et al., Smith, L.M. et al., Wehmeier, S. et al., Jenkins, R.O. et al.

Dopp, Hartmann, Florea, von Recklinghausen, Rabieh, Shokouhi, Hirner, Rettenmeier,

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Disease relevance of trimethylstibane

GC-MS profiles of headspace gases from soil enrichment cultures shown to generate trimethylantimony, were used to select characterised Clostridium spp for assessment of antimony biomethylation capability [1].
There was no evidence to suggest that levels of trimethylantimony or total methylantimony forms in cot mattress foams have a causal relation to SIDS [2].

High impact information on trimethylstibane

Of these five antimony compounds, only stibine and trimethylstibine were genotoxic (significant nicking to pBR 322 plasmid DNA) [3].
Plasmid DNA damage caused by stibine and trimethylstibine [3].
The determined 123/121Sb isotope ratios in the volatile trimethylstibine and non-volatile methylantimony species indicated that the methylation follows the proposed methylation pathway [4].
In our study, we demonstrate that trimethylantimony dichloride (TMSb) does not induce micronucleus (MN) formation, chromosome aberrations (CA) or sister chromatid exchanges (SCE) under normal conditions in Chinese hamster ovary (CHO-9) cells in vitro up to an applied concentration of 1 mM, nor is it significantly cytotoxic [5].

Associations of trimethylstibane with other chemical compounds

We found stibine and trimethylstibine to be about equipotent with trimethylarsine using this plasmid DNA-nicking assay [3].

References

Formation of involatile methylantimony species by Clostridium spp. Smith, L.M., Craig, P.J., Jenkins, R.O. Chemosphere (2002) [Pubmed]
Evaluation of cot mattress inner foam as a potential site for microbial generation of toxic gases. Jenkins, R.O., Morris, T.A., Craig, P.J., Goessler, W., Ostah, N., Wills, K.M. Human & experimental toxicology. (2000) [Pubmed]
Plasmid DNA damage caused by stibine and trimethylstibine. Andrewes, P., Kitchin, K.T., Wallace, K. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
Investigation into antimony mobility in sewage sludge fermentation. Wehmeier, S., Feldmann, J. Journal of environmental monitoring : JEM. (2005) [Pubmed]
Trimethylantimony dichloride causes genotoxic effects in Chinese hamster ovary cells after forced uptake. Dopp, E., Hartmann, L.M., Florea, A.M., von Recklinghausen, U., Rabieh, S., Shokouhi, B., Hirner, A.V., Rettenmeier, A.W. Toxicology in vitro : an international journal published in association with BIBRA. (2006) [Pubmed]

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