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Chemical Compound Review:

AG-G-13304 4,5-dioxopentanoic acid

Synonyms: CHEBI:17204, HMDB13233, AC1L3ORT, AC1Q6PIT, CTK5B0471, ...

Elliott, T. et al., Fukae, R. et al., Ummus, R.E. et al., Couso, R. et al.

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Disease relevance of C02800

Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid in rhodopseudomonas spheroides [1].

High impact information on C02800

In contrast, extracts of both wild-type and hemL cells had gamma,delta-dioxovalerate aminotransferase activity, which indicates that this reaction is not catalyzed by GSA aminotransferase and that the enzyme is not encoded by the hemL gene [2].
Porphyrin precursors, 5-aminolevulinic acid (ALA), 4,5-dioxovaleric acid (DOVA), and porphobilinogen (PBG) can be simultaneously and conveniently analyzed by isotachophoresis [3].

Analytical, diagnostic and therapeutic context of C02800

Measurement of 4,5-dioxovaleric acid by high-performance liquid chromatography and fluorescence detection [4].

References

Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid in rhodopseudomonas spheroides. Couso, R., de Albani, M.D., Locascio, G.A., Tigier, H.A. Experientia (1979) [Pubmed]
Cloning and sequence of the Salmonella typhimurium hemL gene and identification of the missing enzyme in hemL mutants as glutamate-1-semialdehyde aminotransferase. Elliott, T., Avissar, Y.J., Rhie, G.E., Beale, S.I. J. Bacteriol. (1990) [Pubmed]
Analysis of porphyrin precursors, 5-aminolevulinic acid derivatives by isotachophoresis. Fukae, R., Shioi, Y., Sasa, T. Anal. Biochem. (1983) [Pubmed]
Measurement of 4,5-dioxovaleric acid by high-performance liquid chromatography and fluorescence detection. Ummus, R.E., Onuki, J., Dörnemann, D., Medeiros, M.H., Di Mascio, P. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]

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