Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN33731 2-chlorobenzene-1,4-diamine

Synonyms: AG-G-24519, CHEBI:76598, ANW-52958, HSDB 4126, Ursol Brown O, ...

Weisburger, E.K. et al., Picciano, J.C. et al., Hansson, C. et al.

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Disease relevance of NSC6073

Although the analog, 2-chloro-p-phenylenediamine increased transitional cell hyperplasia of the kidney in both male and female rats, it had no significant neoplastic effect at the 0.15 or 0.3% levels fed [1].
Maternal body-weight gain was significantly reduced by the high dose of each dye and the intermediate dose of o-chloro-p-phenylenediamine [2].
Allergic contact dermatitis from 2-chloro-p-phenylenediamine in a cream dye for eyelashes and eyebrows [3].

References

Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice. Weisburger, E.K., Murthy, A.S., Fleischman, R.W., Hagopian, M. Carcinogenesis (1980) [Pubmed]
Evaluation of the teratogenic potential of the oxidative dyes 6-chloro-4-nitro-2-aminophenol and o-chloro-p-phenylenediamine. Picciano, J.C., Morris, W.E., Wolf, B.A. Food Chem. Toxicol. (1984) [Pubmed]
Allergic contact dermatitis from 2-chloro-p-phenylenediamine in a cream dye for eyelashes and eyebrows. Hansson, C., Thorneby-Andersson, K. Contact Derm. (2001) [Pubmed]

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