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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Eyelashes

  • The most prominent features present in the male patients were follicular hyperkeratosis, hyperkeratosis of the calcaneal regions of the soles, scarring alopecia of the scalp, absence of eyebrows and eyelashes, and corneal dystrophy accompanied by photophobia [1].
  • Clinical signs were microcephaly, hemangiomata, long incurved eyelashes, strabismus, enlarged bridge of the nose, abnormally long philtrum, high-arched palate, low set ears, hexadactyly of the four extremities, umbilical and inguinal hernias, neonatal respiratory distress, psychomotor and growth retardation [2].
  • Both patients had severe hypospadias, large fontanelles, cleft palate, and minor facial anomalies (square and prominent forehead, short, downslanting palpebral fissures, long eyelashes, long philtrum, short nose, thin vermilion border with downcurved upper lip) [3].
  • RESULTS: In 43 patients receiving unilateral topical latanoprost, hypertrichosis involved ipsilateral terminal eyelashes and regional intermediate hairs of the upper and lower eyelid as well as vellus hair of the lower eyelid skin [4].
  • Data from spontaneous reporting systems support a possible association of decreased vision, cystoid macular oedema, sicca-like symptoms, discoloration of the eyelids with or without periorbital or eyelid oedema, proptosis, loss of eyebrow or eyelashes, and superficial punctate keratitis with the use of niacin in high doses [5].

High impact information on Eyelashes

  • Excessive growth of eyelashes in a patient with AIDS being treated with zidovudine [6].
  • However, most children with TCS present with the following classic facial features: down-sloping palpebral fissures, colobomata of the lower eyelid, scanty lower eyelashes, malar hypoplasia, and micro- or retrognathia [7].
  • Latanoprost reversed alopecia of the eyelashes in one patient [8].
  • Loss of eyelashes after use of a tinting mascara containing PPD [9].
  • RESULTS: Ophthalmic examination disclosed a best-corrected visual acuity of right eye (RE): 20/25 and left eye (LE): 20/50, burned eyelashes, punctate keratitis, iridocyclitis, anterior subcapsular lens opacity, missing foveolar reflex, and macular pigment epithelial defect LE [10].

Chemical compound and disease context of Eyelashes


Biological context of Eyelashes

  • It was interesting to find an association of AFA with hypoplasia of hair, eyelashes, eyebrows and nails and a karyotype of trisomy 18 in this case [13].

Anatomical context of Eyelashes

  • We describe an 18-year-old girl with a distinctive facial appearence, almost complete absence of the scalp and body hair, absence of the eyebrows and eyelashes, oligodontia, conically shaped maxillary central incisors and zygodactylous palmar triradii suggesting for syndactyly type I [14].

Associations of Eyelashes with chemical compounds


Gene context of Eyelashes


  1. Keratosis follicularis spinulosa decalvans: a family study of seven male cases and six female carriers. van Osch, L.D., Oranje, A.P., Keukens, F.M., van Voorst Vader, P.C., Veldman, E. J. Med. Genet. (1992) [Pubmed]
  2. A new case of trisomy for the distal part of 13q due to maternal translocation, t(9;13)(p21;q21). Jotterand, M., Juillard, E. Hum. Genet. (1976) [Pubmed]
  3. Duplication of 7q31.2----7qter and deficiency of 18qter: report of two patients and literature review. Johnson, D.D., Michels, V.V., Aas, M.A., Dewald, G.W. Am. J. Med. Genet. (1986) [Pubmed]
  4. Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. Johnstone, M.A. Am. J. Ophthalmol. (1997) [Pubmed]
  5. Adverse ocular effects associated with niacin therapy. Fraunfelder, F.W., Fraunfelder, F.T., Illingworth, D.R. The British journal of ophthalmology. (1995) [Pubmed]
  6. Excessive growth of eyelashes in a patient with AIDS being treated with zidovudine. Klutman, N.E., Hinthorn, D.R. N. Engl. J. Med. (1991) [Pubmed]
  7. Fiberoptic tracheal intubation through a laryngeal mask airway in a child with Treacher Collins syndrome. Muraika, L., Heyman, J.S., Shevchenko, Y. Anesth. Analg. (2003) [Pubmed]
  8. Prostaglandin-induced hair growth. Johnstone, M.A., Albert, D.M. Survey of ophthalmology. (2002) [Pubmed]
  9. Loss of eyelashes after use of a tinting mascara containing PPD. Wachsmuth, R., Wilkinson, M. Contact Derm. (2006) [Pubmed]
  10. Abnormal electroretinogram and abnormal electrooculogram after lightning-induced ocular injury. Lin, C.J., Yang, C.H., Yang, C.M., Chang, K.P. Am. J. Ophthalmol. (2002) [Pubmed]
  11. Allergic contact dermatitis from 2-chloro-p-phenylenediamine in a cream dye for eyelashes and eyebrows. Hansson, C., Thorneby-Andersson, K. Contact Derm. (2001) [Pubmed]
  12. Comparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design study. Chiseliţă, D., Antohi, I., Medvichi, R., Danielescu, C. Oftalmologia (Bucharest, Romania : 1990) (2005) [Pubmed]
  13. Ankyloblepharon filiforme adnatum (AFA) associated with trisomy 18. Tüysüz, B., Ilikkan, B., Vural, M., Perk, Y. Turk. J. Pediatr. (2002) [Pubmed]
  14. Almost complete absence of the scalp and body hair in association with oligodontia and zygodactylous palmar triradii. Atasua, M., Dumlu, A., Ozbayrak, S. Clin. Dysmorphol. (2001) [Pubmed]
  15. Prostaglandin analog treatment of glaucoma and ocular hypertension. Alexander, C.L., Miller, S.J., Abel, S.R. The Annals of pharmacotherapy. (2002) [Pubmed]
  16. Retinal evaluation after 810 nm Dioderm laser removal of eyelashes. Pham, R.T., Tzekov, R.T., Biesman, B.S., Marmor, M.F. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2002) [Pubmed]
  17. Pyrocatechol contact allergy from a permanent cream dye for eyelashes and eyebrows. Andersen, K.E., Carlsen, L. Contact Derm. (1988) [Pubmed]
  18. Topical bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension. Easthope, S.E., Perry, C.M. Drugs & aging. (2002) [Pubmed]
  19. Generalized infestation of a 3 1/2-year-old girl with the pubic louse. Klaus, S., Shvil, Y., Mumcuoglu, K.Y. Pediatric dermatology. (1994) [Pubmed]
  20. Cenani-Lenz syndactyly in a patient with features of Kabuki syndrome. Elliott, A.M., Reed, M.H., Evans, J.A., Cross, H.G., Chudley, A.E. Clin. Dysmorphol. (2004) [Pubmed]
  21. Leaf-shaped lesions of ocular fundus and white eyelashes in tuberous sclerosis. Awan, K.J. South. Med. J. (1982) [Pubmed]
  22. Unilateral poliosis of the eyelashes in children associated with vitiligo. Roberts, A., Kaye, L.C., Memon, A., Parslew, R., Kaye, S.B. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus. (2005) [Pubmed]
  23. Autosomal recessive Oliver-McFarlane syndrome: retinitis pigmentosa, short stature (GH deficiency), trichomegaly, and hair anomalies or CPD syndrome (chorioretinopathy-pituitary dysfunction). Haimi, M., Gershoni-Baruch, R. Am. J. Med. Genet. A (2005) [Pubmed]
  24. Ophthalmic findings in GAPO syndrome. Ilker, S.S., Oztürk, F., Kurt, E., Temel, M., Gül, D., Sayli, B.S. Jpn. J. Ophthalmol. (1999) [Pubmed]
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